Division of Hematology
The Division of Hematology, part of the Department of Medicine, offers world-class patient care, research programs, and education and training opportunities.
Cellular & Molecular Biology of Hematopoiesis Research
About Our Program
The Program in Cellular and Molecular Biology of Hematopoiesis investigates how transcription factors regulate the differentiation of hematopoietic stem cells and how disruptions in these pathways contribute to anemia, leukemia and other cancers.
Cellular & Molecular Biology of Hematopoiesis Laboratories
The goal of our research is to develop new treatment and prevention strategies for chronic anemia. Learn more about our research:
- Tenen Lab: The Tenen lab has defined key roles for transcription factors PU.1 and C/EBPα in myeloid development, uncovering their regulation of genes essential for granulocyte and monocyte lineages and identifying their mutations and dysfunction in myeloid leukemias. His research has also focused on the molecular mechanisms governing PU.1 and C/EBPα activity, their role in leukemogenesis, and the development of targeted therapies.
Additional projects use murine models of leukemia, including inducible fusion proteins such as Bcr-Abl, and leverage myeloid promoters for lineage- and stage-specific gene expression, with the long-term goal of advancing gene therapy approaches for acute myelogenous leukemia and related disorders.
