Anti-Amyloid Therapy for Alzheimer's Disease

DiAD Clinic at BIDMC

The Dominantly Inherited Alzheimer’s Disease (DiAD) Clinic at Beth Israel Deaconess Medical Center (BIDMC) leads the way in Alzheimer’s disease care. We were the first clinic in Massachusetts to offer lecanemab, and today we provide both lecanemab and donanemab, two breakthrough FDA-approved anti-amyloid therapies. These treatments give patients and families new hope by slowing the progression of Alzheimer’s disease.

About Anti-Amyloid Therapy

Lecanemab and donanemab are antibody therapies that remove beta-amyloid, a protein that builds up in the brain and contributes to Alzheimer’s disease progression.

• They are not cures, but they can slow memory and functional decline by about 30% over 18 months.
• Best suited for patients with mild cognitive impairment or early-stage Alzheimer’s dementia.
• Treatment schedules differ:
  • Lecanemab: infusions every two weeks
  • Donanemab: infusions every four weeks

Why Choose the BIDMC DiAD Clinic?

• Pioneers in Alzheimer’s care: First in Massachusetts to offer anti-amyloid therapy
• Comprehensive expertise: Cognitive neurologists, neuropsychiatrists, neuropsychologists and clinical social workers
• Personalized treatment plans: Tailored evaluations, safety monitoring and supportive services
• Ongoing care: Infusion therapy, regular MRIs, telehealth and in-person visits, and seamless coordination with your regular neurologist

What to Expect in Treatment

Your journey begins with a full evaluation — neurologic exam, memory testing, bloodwork and imaging. If eligible, you’ll work with your care team to start treatment:

• Infusion therapy: sessions last one-to-three hours depending on the medication
• Monitoring: routine MRIs and check-ins to track safety and progress
• Comprehensive support: telehealth visits, counseling and coordination with your neurologist

What to Look Out For

While many patients tolerate treatment well, some side effects may occur

• Infusion reactions: Fever, flu-like symptoms, rash, dizziness or shortness of breath. Most are mild and manageable.
• Brain swelling or bleeding (ARIA): Often detected only on MRI; occasionally causes headache, vision changes or confusion. Rarely, more serious symptoms like seizures or stroke-like symptoms can occur.

Our team carefully monitors you at every step. Most side effects resolve on their own, and treatment can often continue after appropriate management.

Costs and Insurance

• Lecanemab costs about $26,500 annually; donanemab costs vary.
• Medicare covers about 80%, but insurance coverage depends on your plan.
• Our team works with you and your insurer to coordinate approvals and minimize delays