Allergy & Inflammation Research

Clinical Research

The Division of Allergy and Inflammation has participated in NIH and corporate-sponsored clinical research. Prior studies have documented the utility of   neutralizing antibodies to interleukin-5 for eosinophilic diseases, including the Hypereosinophilic Syndrome (HES) and Eosinophilic Granulomatosis and Polyangiitis (EGPA)  The Division has also collaborated on clinical projects with other Harvard Medical School institutions and divisions, and has collaborated on epidemiological research with the Channing Lab and the Harvard T. H. Chan School of Public Health. Allergy & Inflammation Research Laboratories 

The research activities of the Division of Allergy and Inflammation include both clinical and basic research. Our basic research labs include:

• Weller Lab: Led by Peter F. Weller, MD, this lab centers around understanding mechanisms of leukocyte functioning in forms of inflammation. A central focus has been on delineating the immunobiology of eosinophils.  These studies have included investigations of the roles of eosinophils as antigen-presenting cells.  For human eosinophils, studies have elucidated mechanisms that regulate the secretion of eosinophil-derived cytokines.  Contemporary work includes investigations of the function of the Charcot-Leyden crystal protein, a prominent and evolutionarily unique component of human eosinophils.