Advanced Endoscopy Research

About Our Research

BIDMC has a leadership role in local, national, and international research trials investigating new endoscopic technologies.

Endoscopy Research TrialsBIDMC's Center for Endoscopic Innovation (CEI) is a leader in local, national, and international research trials investigating new endoscopic technologies.

Current areas of active investigation include:

  • Cryoablation techniques for eradication of Barrett's esophagus
  • Use of lumen-apposing metal stents for pancreatic drainage and necrosectomy
  • Novel treatments for GERD
  • Fine needle biopsy techniques for pancreatic cancer and cysts to grow 'organoids' for discovery and validation of personalized chemotherapetic approaches
  • Quality and safety in endoscopy and GI anesthesia
  • Artificial intelligence applications for GI endoscopy
  • Developmental research in advanced resection and third space endoscopy

Our Investigators

Publications

Recent publications from the Center for Endoscopic Innovation include:

Outcomes after endoscopic retrograde cholangiopancreatography with general anaesthesia versus sedation. Althoff FC, Agnihotri A, Grabitz SD, Santer P, Nabel S, Tran T, Berzin TM, Sundar E, Xu X, Sawhney MS, Eikermann M. Br J Anaesth. 2021 Jan.

Benchmarking definitions of false-positive alerts during computer-aided polyp detection in colonoscopy. Holzwanger EA, Bilal M, Glissen Brown JR, Singh S, Becq A, Ernest-Suarez K, Berzin TM. Endoscopy. 2020 Nov 2.

Incorporating standardised reporting guidelines in clinical trials of artificial intelligence in gastrointestinal endoscopy. Bilal M, Brown JRG, Berzin TM. Lancet Gastroenterol Hepatol. 2020 Nov.

ERCP in patients with COVID-19 infection - is a single-use duodenoscope the safer option? Bilal M, Berzin TM, Cohen J, Sawhney MS, Pleskow DK. Endoscopy. 2020 Oct.

Factors Associated with complete clip closure after Endoscopic Mucosal Resection of Large Colorectal Polyps. Ortiz O, Rex DK, Ian G, Moyer M, Hasan MK, Pleskow D, Elmunzer JB, Khashab MA, Sanaei O, Al-Kawas F, Gordon SR, Mathew A, Levenick J, Aslanian H, Antaki F, von Renteln D, Crockett S, Rastogi A, Gill J, Law RJ, Wallace MB, Elias P, MacKenzie TA, Pohl H, Pellisé M. Endoscopy. 2020 Dec 8.

Fine-needle aspiration of pancreatic cystic lesions: A randomized study comparing standard and flexible needles with long-term follow-up. Al-Haddad M, Wallace MB, Brugge W, Lakhtakia S, Li Z, Sethi A, Pleskow D, Nguyen C, Pannala R, DeWitt JM, Raimondo M, Woodward T, Ramchandani M, Jin Z, Xu C, Faigel DO. Endoscopy. 2020 Nov 16.

Prospective assessment of the effectiveness of standard high-level disinfection for echoendoscopes. Becq A, Snyder GM, Heroux R, Wright SB, Bharadwaj S, Cohen J, Gabr M, Berzin TM, Pleskow DK, Sawhney MS. Gastrointest Endosc. 2019 Jan 14.

Direct endoscopic necrosectomy at the time of transmural stent placement results in earlier resolution of complex walled-off pancreatic necrosis: Results from a large multicenter. United States trial. Yan L, Dargan A, Nieto J, Shariaha RZ, Binmoeller KF, Adler DG, DeSimone M, Berzin T, Sawhney M, Draganov PV, Yang DJ, Diehl DL, Wang L, Ghulab A, Butt N, Siddiqui AA. Endosc. Ultrasound. 2018 Jun 6

Randomized study of digital single-operator cholangioscope compared to fiberoptic single-operator cholangioscope in a novel cholangioscopy bench model. Shah RJ, Neuhaus H, Parsi M, Reddy DN, Pleskow DK. Endosc Int Open. 2018 Jul;6(7):E851-E856

Development and validation of a deep-learning algorithm for the detection of polyps during colonoscopy. Wang P, Xiao, X, Glissen-Brown JR, Berzin TM, Tu M, Xiong F, Hu X, Liu P, Song Y, Zhang D, Yang X, Li L, He J, Yi X, Liu J, Liu X. Nature Biomedical Engineering. 2018; (2):741-748.

Increased detection of Barrett's esophagus-associated neoplasia using wide-area trans-epithelial sampling: a multicenter, prospective, randomized trial. Vennalaganti PR, Kaul V, Wang KK, Falk GW, Shaheen NJ, Infantolino A, Johnson DA, Eisen G, Gerson LB, Smith MS, Iyer PG, Lightdale CJ, Schnoll-Sussman F, Gupta N, Gross SA, Abrams J, Haber GB, Chuttani R, Pleskow DK, Kothari S, Goldblum JR, Zhang Y, Sharma P. Gastrointest Endosc. 2018 Feb;87(2):348-355.

Randomized Comparison of 3 High-Level Disinfection and Sterilization Procedures for Duodenoscopes. Snyder GM, Wright SB, Smithey A, Mizrahi M, Sheppard M, Hirsch EB, Chuttani R, Heroux R, Yassa DS, Olafsdottir LB, Davis RB, Anastasiou J, Bapat V, Bidari K, Pleskow DK, Leffler D, Lane B, Chen A, Gold HS, Bartley A, King AD, Sawhney MS. Gastroenterology. 2017 Oct;153(4):1018-1025.

Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy. Zhang L, Pleskow DK, Turzhitsky V, Yee EU, Berzin TM, Sawhney M, Shinagare S, Vitkin E, Zakharov Y, Khan U, Wang F, Goldsmith JD, Goldberg S, Chuttani R, Itzkan I, Qiu L, Perelman LT. Nat Biomed Eng. 2017;1. Mar 13.

Computer-aided diagnosis for colonoscopy. Mori Y, Kudo SE, Berzin TM, Misawa M, Takeda K. Endoscopy. 2017 Aug;49(8):813-819.

Learning curve and competence for volumetric laser endomicroscopy in Barrett's esophagus using cumulative sum analysis. Trindade AJ, Inamdar S, Smith MS, Rosen L, Han D, Chang KJ, Leggett CL, Lightdale CJ, Pleskow DK, Sejpal DV, Tearney GJ, Thomas RM, Wallace MB. Endoscopy. 2017 Nov 27. doi: 10.1055/s-0043-121569.

Performance of a fully disposable, digital, single-operator cholangiopancreatoscope. Shah RJ, Raijman I, Brauer B, Gumustop B, Pleskow DK. Endoscopy. 2017 Jul;49(7):651-658.

Initial experience with a novel EUS-guided core biopsy needle (SharkCore): results of a large North American multicenter study. DiMaio CJ, Kolb JM, Benias PC, Shah H, Shah S, Haluszka O, Maranki J, Sharzehi K, Lam E, Gordon SR, Hyder SM, Kaimakliotis PZ, Allaparthi SB, Gress FG, Sethi A, Shah AR, Nieto J, Kaul V, Kothari S, Kothari TH, Ho S, Izzy MJ, Sharma NR, Watson RR, Muthusamy VR, Pleskow DK, Berzin TM, Sawhney M, Aljahdi E, Ryou M, Wong CK, Gupta P, Yang D, Gonzalez S, Adler DG. Endosc Int Open. 2016 Sep;4(9):E974-9.