Mantzoros Lab Selected Publications
Research by the Mantzoros Lab
The Mantzoros Lab has published research papers on various metabolic diseases, including obesity, diabetes, and nonalcoholic fatty liver disease. View selected research publications by the Mantzoros Lab below.
Paz-Graniel I, García-Gavilán JF, Ros E, Connelly MA, Babio N, Mantzoros CS, Salas-Salvadó J. Adherence to the Mediterranean diet and nuclear magnetic resonance spectroscopy biomarkers in older individuals at high cardiovascular disease risk: cross-sectional and longitudinal analyses. Am J Clin Nutr. 2024 Jan;119(1):108-116. Doi: 10.1016/j.ajcnut.2023.11.003. Epub 2023 Nov 10. PMID: 37949173.
Tan DJH, Ng CH, Muthiah M, Yong JN, Chee D, Teng M, Wong ZY, Zeng RW, Chin YH, Wang JW, Danpanichkul P, Rajaram RB, DasGupta R, Suzuki H, Takahashi H, Tamaki N, Dan YY, Lui R, Duseja A, Siddiqui MS, Yeoh KG, Sanyal A, Wijarnpreecha K, Loomba R, Mantzoros CS, Huang DQ. Rising global burden of cancer attributable to high BMI from 2010 to 2019. Metabolism. 2024 Mar;152:155744. Doi: 10.1016/j.metabol.2023.155744. Epub 2023 Nov 27. PMID: 38029839.
Kokkinos A, Tsilingiris D, Simati S, Stefanakis K, Angelidi AM, Tentolouris N, Anastasiou IA, Connelly MA, Alexandrou A, Mantzoros CS. Bariatric surgery, through beneficial effects on underlying mechanisms, improves cardiorenal and liver metabolic risk over an average of ten years of observation: A longitudinal and a case-control study. Metabolism. 2024 Mar;152:155773. Doi: 10.1016/j.metabol.2023.155773. Epub 2024 Jan 3. PMID: 38181882; PMCID: PMC10872266.
Zagkos L, Cronjé HT, Woolf B, de La Harpe R, Burgess S, Mantzoros CS, Elliott P, Yuan S, Larsson SC, Tzoulaki I, Gill D. Genetic investigation into the broad health implications of caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization. BMC Med. 2024 Feb 20;22(1):81. Doi: 10.1186/s12916-024-03298-y. PMID: 38378567; PMCID: PMC10880284.
Angelidi AM, Stefanakis K, Chou SH, Valenzuela-Vallejo L, Dipla K, Boutari C, Ntoskas K, Tokmakidis P, Kokkinos A, Goulis DG, Papadaki HA, Mantzoros CS. Relative Energy Deficiency in sport (REDs): Endocrine manifestations, pathophysiology and treatments. Endocr Rev. 2024 Mar 15:bnae011. Doi: 10.1210/endrev/bnae011. Epub ahead of print. PMID: 38488566.
Chew NWS, Ng CH, Tan DJH, Kong G, Lin C, Chin YH, Lim WH, Huang DQ, Quek J, Fu CE, Xiao J, Syn N, Foo R, Khoo CM, Wang JW, Dimitriadis GK, Young DY, Siddiqui MS, Lam CSP, Wang Y, Figtree GA, Chan MY, Cummings DE, Noureddin M, Wong VW, Ma RCW, Mantzoros CS, Sanyal A, Muthiah MD. The global burden of metabolic disease: Data from 2000 to 2019. Cell Metab. 2023 Mar 7;35(3):414-428.e3. doi: 10.1016/j.cmet.2023.02.003. PMID: 36889281.
Chakhtoura M, Haber R, Ghezzawi M, Rhayem C, Tcheroyan R, Mantzoros CS. Pharmacotherapy of obesity: an update on the available medications and drugs under investigation. EClinicalMedicine. 2023 Mar 20;58:101882. doi: 10.1016/j.eclinm.2023.101882. PMID: 36992862; PMCID: PMC10041469.
Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, Arrese M, Bataller R, Beuers U, Boursier J, Bugianesi E, Byrne CD, Castro Narro GE, Chowdhury A, Cortez-Pinto H, Cryer DR, Cusi K, El-Kassas M, Klein S, Eskridge W, Fan J, Gawrieh S, Guy CD, Harrison SA, Kim SU, Koot BG, Korenjak M, Kowdley KV, Lacaille F, Loomba R, Mitchell-Thain R, Morgan TR, Powell EE, Roden M, Romero-Gómez M, Silva M, Singh SP, Sookoian SC, Spearman CW, Tiniakos D, Valenti L, Vos MB, Wong VW, Xanthakos S, Yilmaz Y, Younossi Z, Hobbs A, Villota-Rivas M, Newsome PN; NAFLD Nomenclature consensus group. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology. 2023 Dec 1;78(6):1966-1986. doi: 10.1097/HEP.0000000000000520. Epub 2023 Jun 24. PMID: 37363821; PMCID: PMC10653297.
Yuan S, Xu F, Li X, Chen J, Zheng J, Mantzoros CS, Larsson SC. Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses. Cell Rep Med. 2023 Sep 19;4(9):101174. doi: 10.1016/j.xcrm.2023.101174. Epub 2023 Aug 30. PMID: 37652020; PMCID: PMC10518626.
Kokkorakis M, Folkertsma P, van Dam S, Sirotin N, Taheri S, Chagoury O, Idaghdour Y, Henning RH, Forte JC, Mantzoros CS, de Vries DH, Wolffenbuttel BHR. Effective questionnaire-based prediction models for type 2 diabetes across several ethnicities: a model development and validation study. EClinicalMedicine. 2023 Sep 25;64:102235. doi: 10.1016/j.eclinm.2023.102235. PMID: 37936659; PMCID: PMC10626169.
Angelidi AM, Kokkinos A, Sanoudou D, Connelly MA, Alexandrou A, Mingrone G, Mantzoros CS. Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity. Metabolism. 2023 Jan. PMID 36375643. IF:13.93
Rogalska ME, Vafiadaki E, Erpapazoglou Z, Haghighi K, Green L, Mantzoros CS, Hajjar RJ, Tranter M, Karakikes I, Kranias EG, Stillitano F, Kafasla P, Sanoudou D. Isoform changes of action potential regulators in the ventricles of arrhythmogenic phospholamban-R14del humanized mouse hearts. Metabolism. 2023 Jan. PMID 36375644. IF:13.93
Bouzoni E, Perakakis N, Connelly MA, Angelidi AM, Pilitsi E, Farr O, Stefanakis K, Mantzoros CS. PCSK9 and ANGPTL3 levels correlate with hyperlipidemia in HIV-lipoatrophy, are regulated by fasting and are not affected by leptin administered in physiologic or pharmacologic doses. Metabolism. 2022 Jul 9;134:155265. doi: 10.1016/j.metabol.2022.155265. Online ahead of print. PMID:35820631 IF: 13.93
Valenzuela-Vallejo L, Chysafi P, Mantzoros CS. Liraglutide-induced effects on energy intake and glycemic profile are independent of total and intact GDF-15 levels in subjects with obesity and diabetes. Diabetes Metab. 2022. IF: 8.2
Kouvari M, Polyzos S, Chrysohoou S, Skoumas J, Pitsavos C, Panagiotakos D, Mantzoros CS. Skeletal Muscle Mass and Abdominal Obesity are Independent Predictors of Hepatic Steatosis and Interact to Predict Ten-Year Cardiovascular Disease Incidence: Data from ATTICA Cohort Study. Clinical Nutrition. 2022. doi.org/10.1016/j.clnu.2022.03.022. IF: 7.324
Markozannes G, N zani EE, Tsapas A, Mantzoros CS, Tsiara S, Xanthos T, Karpettas N, Patrikios I, Rizos EC. Dose-related meta-analysis for Omega-3 fatty acids supplementation on major adverse cardiovascular events. Clin Nutr. 2022 Mar 4;41(4):923-930. PMID: 35290840, doi: 10.1016/j.clnu.2022.02.022. IF: 7.324
Valenzuela-Vallejo L, Chysafi P, Mantzoros CS. Liraglutide-induced effects on energy intake and glycemic profile are independent of total and intact GDF-15 levels in subjects with obesity and diabetes. Diabetes Metab. 2022 (in press). IF: 8.2
Phillips BE, Lantier L, Engman C, Garciafigueroa Y, Singhi A, Trucco M, Mantzoros C, Wasserman D, Giannoukakis N. Improvement in insulin sensitivity and prevention of high fat diet-induced liver pathology using a CXCR2 antagonist. Cardiovasc Diabetol. 2022 Jul 12;21(1):130. doi: 10.1186/s12933-022-01564-y. PMCID:9277870, PMID: 35831885. IF: 9.951
Boutari C, Pappas P.D, Anastasilakis D, Mantzoros CS. Statins’ efficacy in non-alcoholic fatty liver disease: A systematic review and meta-analysis. Clinical Nutrition. 2022 (in press). IF: 7.324
Perakakis N, Farr OM, Mantzoros CS. Fasting oxyntomodulin, glicentin, and GIP levels are associated with activation of reward and attention-related brain centers in response to visual food cues in adults with obesity: A cross-sectional fMRI study. Diabetes Obes Metab. 2021 23(5):1202-1207. PMID: 33417264. doi: 10.1111/dom.14315., IF: 6.577
Tuccinardi D, Perakakis N, Farr OM, Upadhyay J, Mantzoros CS. Branched-Chain Amino Acids in relation to Food Preferences and Insulin Resistance in Obese Subjects Consuming Walnuts: A Cross-Over, Randomized, Double-Blind, Placebo-Controlled inpatient physiology study. Clin Nutr. 2021 23:S0261-5614(21)00030-3. PMID: 33541836 PMCID: PMC8172419. doi: 10.1016/j.clnu.2021.01.020. IF: 7.324
Panagiotou G, Ghaly W, Upadhyay J, Pazaitou-Panayiotou K, Mantzoros CS. Serum follistatin is increased in thyroid cancer and is associated with adverse tumor characteristics in humans. J Clin Endocrinol Metab. 2021 23;106(5):e2137-e2150. PMID: 33493282. doi: 10.1210/clinem/dgab041. IF: 5.958
Akinci B, Subauset A, Ajluni N, Esfandiari NH, Rasimcan M, Neidert AH, Eraslan A, Hench R, Rus D, Mckenna B, Hussain HK, Chenevert TL, Tayeh MK, Rupani AR, Innis JW, Mantzoros CS, Conjeevaram HS, Burant CL, Oral EA. Metreleptin therapy for nonalcoholic steatohepatitis: Open-label therapy interventions in two different clinical settings. Med. 2021 Jul 9; 794-796. doi: 10.1016/j.medj.2021.04.001.
Toumba M, Fanis P, Vlachakis D, Neocleous V, Phylactou LA, Skordis N, Mantzoros CS, Pantelidou M. Molecular modelling of novel ADCY3 variant predicts a molecular target for tackling obesity. Int J Mol Med. 2022. 2021.5065. PMID: 34821371, PMCID: PMC8651229.Doi.10.3892/ijmm.2021.5065. IF.3.82
Christodoulou A, Ierodiakonou D, Awofala AA, Petrou M, Kales SN, Christiani DC, Mantzoros CS, Christophi CA. Variants in ADIPOQ gene are linked to adiponectin levels and lung function in young Cypriot males independent of obesity. PLoS One. 2020 Jan 24;15(1):e0225662. doi: 10.1371/journal.pone.0225662. eCollection 2020. PMID: 31978107. IF: 3.240
Perakakis N, Kokkinos A, Peradze N, Tentolouris N, Ghaly W, Tsilingiris D, Alexandrou A, Mantzoros CS. Metabolic regulation of activins in healthy individuals and in obese patients undergoing bariatric surgery. Diabetes Metab Res Rev. 2020 Jul;36(5):e3297. doi: 10.1002/dmrr.3297. Epub 2020 Mar 1. PMID: 32026536. IF: 4.876
Neocleous V, Fanis P, Toumba M, Tanteles GA, Schiza M, Cinarli F, Nicolaides NC, Oulas A, Spyrou GM, Mantzoros CS, Vlachakis D, Skordis N, Phylactou LA. GnRH Deficient Patients With Congenital Hypogonadotropic Hypogonadism: Novel Genetic Findings in ANOS1, RNF216, WDR11, FGFR1, CHD7, and POLR3A Genes in a Case Series and Review of the Literature. Front Endocrinol (Lausanne). 2020 Aug 28;11:626. doi: 10.3389/fendo.2020.00626. PMID: 32982993; PMCID: PMC7485345. IF: 3.675
Chrysafi P, Perakakis N, Farr OM, Stefanakis K, Peradze N, Sala-Vila A, Mantzoros CS. Leptin alters energy intake and fat mass but not energy expenditure in lean subjects. Nat Commun. 2020 Oct 13;11(1):5145. doi: 10.1038/s41467-020-18885-9. PMID: 33051459; PMCID: PMC7553922. *co-first authors. IF: 14.919
Kouvari M, Boutari C, Chrysohoou C, Fragkopoulou E, Antonopoulou S, Tousoulis D, Pitsavos C, Panagiotakos DB, Mantzoros CS; ATTICA study Investigators. Mediterranean diet is inversely associated with steatosis and fibrosis and decreases ten-year diabetes and cardiovascular risk in NAFLD subjects: Results from the ATTICA prospective cohort study. Clin Nutr. 2020 Nov 7:S0261-5614(20)30605-1. doi: 10.1016/j.clnu.2020.10.058. Epub ahead of print. PMID: 33234342. IF: 7.324
Tuccinardi D, Farr OM, Upadhyay J, Oussaada SM, Mathew H, Paschou SA, Perakakis N, Koniaris A, Kelesidis T, Mantzoros CS. Lorcaserin treatment decreases body weight and reduces cardiometabolic risk factors in obese adults: A six-month, randomized, placebo-controlled, double-blind clinical trial. Diabetes Obes Metab. 2019 Jun;21(6):1487-1492. doi: 10.1111/dom.13655. Epub 2019 Mar 18. PMID: 30724455.
Perakakis N, Kokkinos A, Peradze N, Tentolouris N, Ghaly W, Tsilingiris D, Alexandrou A, Mantzoros CS. Follistatins in glucose regulation in healthy and obese individuals. Diabetes Obes Metab. 2019 Mar;21(3):683-690. doi: 10.1111/dom.13572. Epub 2018 Dec 3.
Panagiotou G, Papakonstantinou E, Vagionas A, Polyzos SA, Mantzoros CS. Serum Levels of Activins, Follistatins, and Growth Factors in Neoplasms of the Breast: A Case-Control Study. J Clin Endocrinol Metab. 2019 Feb 1;104(2):349-358. doi: 10.1210/jc.2018-01581. PMID: 30388235.
Görgülü K, Diakopoulos KN, Ai J, Schoeps B, Kabacaoglu D, Karpathaki AF, Ciecielski KJ, Kaya-Aksoy E, Ruess DA, Berninger A, Kowalska M, Stevanovic M, Wörmann SM, Wartmann T, Zhao Y, Halangk W, Voronina S, Tepikin A, Schlitter AM, Steiger K, Artati A, Adamski J, Aichler M, Walch A, Jastroch M, Hartleben G, Mantzoros CS, Weichert W, Schmid RM, Herzig S, Krüger A, Sainz B Jr, Lesina M, Algül H. Levels of the Autophagy Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice. Gastroenterology. 2018 Oct 5. pii: S0016-5085(18)35087-X. doi: 10.1053/j.gastro.2018.09.053. [Epub ahead of print] PubMed PMID: 30296435. IF: 20.77
Perakakis N, Yazdani A, Karniadakis GE, Mantzoros C. Omics, big data and machine learning as tools to propel understanding of biological mechanisms and to discover novel diagnostics and therapeutics. Metabolism. 2018 Oct;87:A1-A9. doi: 10.1016/j.metabol.2018.08.002. Epub 2018 Aug 8. PubMed PMID: 30098323; PubMed Central PMCID: PMC6325641.
Perakakis N, Mougios V, Fatouros I, Siopi A, Draganidis D, Peradze N, Ghaly W, Mantzoros CS. Physiology of Activins/Follistatins: Associations With Metabolic and Anthropometric Variables and Response to Exercise. J Clin Endocrinol Metab. 2018 Oct 1;103(10):3890-3899. doi: 10.1210/jc.2018-01056. PubMed PMID: 30085147; PubMed Central PMCID: PMC6179167.
Farr OM, Mantzoros CS. Obese individuals with type 2 diabetes demonstrate decreased activation of the salience-related insula and increased activation of the emotion/salience-related amygdala to visual food cues compared to non-obese individuals with diabetes: A preliminary study. Diabetes Obes Metab. 2018 Oct;20(10):2500-2503. doi: 10.1111/dom.13403. Epub 2018 Jul 2. PubMed PMID: 29882627; PubMed Central PMCID: PMC6133716.
Farr OM, Tuccinardi D, Upadhyay J, Oussaada SM, Mantzoros CS. Walnut consumption increases activation of the insula to highly desirable food cues: A randomized, double-blind, placebo-controlled, cross-over fMRI study. Diabetes Obes Metab. 2018 Jan;20(1):173-177. doi: 10.1111/dom.13060. Epub 2017 Aug 17. PubMed PMID: 28715141; PubMed Central PMCID: PMC5720909.
Polyzos SA, Kountouras J, Mantzoros CS, Polymerou V, Katsinelos P. Effects of combined low-dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non-invasive indices of steatosis and fibrosis, and adipokine levels in non-alcoholic fatty liver disease: a randomized controlled trial. Diabetes Obes Metab. 2017 Dec;19(12):1805-1809. doi: 10.1111/dom.12989. Epub 2017 Jul 10. PubMed PMID: 28452101.
Farr OM, Mantzoros CS. Treating prediabetes in the obese: are GLP-1 analogues the answer? Lancet. 2017 Apr 8;389(10077):1371-1372. doi: 10.1016/S0140-6736(17)30315-X. Epub 2017 Feb 23. PubMed PMID: 28237265.
Farr OM, Sofopoulos M, Tsoukas M, Dincer F, Thakkar B, Sahin-Efe A, Fillippaios A, Bowers J, Srnka A, Gavrieli A, Ko BJ, Liakou C, Kanyuch N, Tseleni-Balafouta S, Mantzoros CS. GLP-1 receptors exist in the parietal cortex, hypothalamus, and medulla of human brains and the GLP-1 analog liraglutide administered in the context of a cross-over, randomized, placebo-controlled trial alters brain activity related to attention to highly desirable food cues in individuals with diabetes. Diabetologia. 2016 May;59(5):954-65. doi: 10.1007/s00125-016-3874-y. PubMed PMID: 26831302; PubMed Central PMCID: PMC4826792. IF: 6.671
Vamvini MT, Hamnvik OP, Sahin-Efe A, Gavrieli A, Dincer F, Farr OM, Mantzoros CS. Differential effects of oral and intravenous lipid administration on key molecules related to energy homeostasis. J Clin Endocrinol Metab. 2016 May;101(5):1989-97. doi: 10.1210/jc.2015-4141. Pubmed PMID:26964729. IF: 6.310
Fleisch AF, Luttmann-Gibson H, Perng W, Rifas-Shiman SL, Coull BA, Kloog I, Koutrakis P, Schwartz JD, Zanobetti A, Mantzoros CS, Gillman MW, Gold DR, Oken E. Prenatal and early life exposure to traffic pollution and cardiometabolic health in childhood. Pediatr Obes. 2016 Feb 4. doi: 10.1111/ijpo.12106. PubMed PMID: 26843357. IF: 4.573
Gasbarrino K, Mantzoros C, Gorgui J, Veinot JP, Lai C, Daskalopoulou SS. Circulating Chemerin Is Associated With Carotid Plaque Instability, Whereas Resistin Is Related to Cerebrovascular Symptomatology. Arterioscler Thromb Vasc Biol. 2016 Jun 16. pii: ATVBAHA.115.306741. PubMed PMID: 27312219. IF: 6
Farr OM, Tsoukas MA, Triantafyllou G, Dincer F, Filippaios A, Ko BJ, Mantzoros CS. Short-term administration of the GLP-1 analog liraglutide decreases circulating leptin and increases GIP levels and these changes are associated with alterations in CNS responses to food cues: A randomized, placebo-controlled, crossover study. Metabolism. 2016 Jul;65(7):945-53. doi: 10.1016/j.metabol.2016.03.009. Epub 2016 Mar 18. PubMed PMID: 27282865; PubMed Central PMCID: PMC4902873. IF: 4.4
Farr OM, Upadhyay J, Gavrieli A, Camp M, Spyrou N, Kaye H, Mathew H, Vamvini M, Koniaris A, Kilim H, Srnka A, Migdal A, Mantzoros CS. Lorcaserin administration decreases activation of brain centers in response to food cues and these emotion- and salience-related changes correlate with weight loss effects: a four week long randomized, placebo-controlled, double-blinded clinical trial. Diabetes. 2016 Jul 6. pii: db160635. PubMed PMID: 27385157. IF: 8.8.
Anastasilakis A, Polyzos S, Skouvaklidou E, Kinigopoulos G, Saridakis Z, Apostolou A, Triantafyllou G, Karagiozoglou-Lampoudi T, Mantzoros CS. Circulating follistatin displays a day night rhythm and is associated with muscle mass and circulating leptin levels in healthy young humans. Metabolism 2016 (in press). IF: 4.4.
Polyzos SA, Aronis KN, Kountouras J, Raptis DD, Vasiloglou MF, Mantzoros CS. Circulating leptin in non-alcoholic fatty liver disease: a systematic review and meta-analysis. Diabetologia. 2016 Jan;59(1):30-43. doi: 10.1007/s00125-015-3769-3. PubMed PMID: 26407715. IF:6.671
Foo J, Aronis KN, Chamberland JP, Mantzoros CS. Lack of day/night variation in fibroblast growth factor 21 levels in young healthy men. Int J Obes (Lond). 2014; 26. doi: 10.1038/ijo.2014.215. [Epub ahead of print] PubMed PMID: 25540981. IF:5.386
Aronis KN, Moreno M, Polyzos SA, Moreno-Navarrete JM, Ricart W, Delgado E, de la Hera J, Sahin-Efe A, Chamberland JP, Berman R, Spiro A 3rd, Vokonas P, Fernández-Real JM, Mantzoros CS. Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events. Int J Obes (Lond). 2015;39(1):156-61. doi: 10.1038/ijo.2014.101. Epub 2013 Jun 11. PMID: 24916788. IF:5.386
Moon HS, Huh JY, Dincer F, Schneider BE, Hasselgren PO, Mantzoros CS. Identification and saturable nature of signaling pathways induced by metreleptin in humans: comparative evaluation of in vivo, ex vivo, and in vitro administration. Diabetes. 2015;64(3):828-39. doi: 10.2337/db14-0625. Epub 2014 Sep 23. PMID: 25249580. IF:8.474
Diakopoulos KN, Lesina M, Wörmann S, Song L, Aichler M, Schild L, Artati A, Römisch-Margl W, Wartmann T, Fischer R, Kabiri Y, Zischka H, Halangk W, Demir IE, Pilsak C, Walch A, Mantzoros CS, Steiner JM, Erkan M, Schmid RM, Witt H, Adamski J, Algül H. Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes. Gastroenterology. 2015;148(3):626-638.e17. doi: 10.1053/j.gastro.2014.12.003. Epub 2014 Dec 11. PMID: 25497209. IF:13.926
Oken E, Baccarelli AA, Gold DR, Kleinman KP, Litonjua AA, De Meo D, Rich-Edwards JW, Rifas-Shiman SL, Sagiv S, Taveras EM, Weiss ST, Belfort MB, Burris HH, Camargo CA Jr, Huh SY,Mantzoros C, Parker MG, Gillman MW. Cohort profile: project viva. Int J Epidemiol. 2015;44(1):37-48. doi: 10.1093/ije/dyu008. Epub 2014 Mar 16. PMID: 24639442. IF:9.197
Huh JY, Siopi A, Mougios V, Park KH, Mantzoros CS. Irisin in response to exercise in humans with and without metabolic syndrome. J Clin Endocrinol Metab. 2015;100(3):E453-7. doi: 10.1210/jc.2014-2416. Epub 2014 Dec 16.PMID: 25514098. IF:6.310
Ahasic AM, Tejera P, Wei Y, Su L, Mantzoros CS, Bajwa EK, Thompson BT, Christiani DC. Predictors of Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 in Critical Illness. Crit Care Med. 2015 Dec;43(12):2651-9. doi: 10.1097/CCM.0000000000001314. PMID: 26427594. IF: 6.312
Liu X, Huh JY, Gong H, Chamberland JP, Brinkoetter MT, Hamnvik OP, Mantzoros CS. Lack of mature lymphocytes results in obese but metabolically healthy mice when fed a high fat diet. Int J Obes (Lond). 2015 May 21. doi: 10.1038/ijo.2015.93. [Epub ahead of print] PubMed PMID: 25994806. IF: 5.386
Inamura K, Song M, Jung S, Nishihara R, Yamauchi M, Lochhead P, Qian ZR, Kim SA, Mima K, Sukawa Y, Masuda A, Imamura Y, Zhang X, Pollak MN, Mantzoros CS, Harris CC, Giovannucci E, Fuchs CS, Cho E, Chan AT, Wu K, Ogino S. Prediagnosis Plasma Adiponectin in Relation to Colorectal Cancer Risk According to KRAS Mutation Status. J Natl Cancer Inst. 2015 Nov 23;108(4). pii: djv363. doi:10.1093/jnci/djv363. Print 2016 Apr. PubMed PMID: 26598515; PubMed Central PMCID:PMC4668768. IF: 13.584
Joung KE, Park KH, Zaichenko L, Sahin-Efe A, Thakkar B, Brinkoetter M, Usher N, Warner D, Davis CR, Crowell JA, Mantzoros CS. Early life adversity is associated with elevated levels of circulating leptin, irisin, and decreased levels of adiponectin in midlife adults. J Clin Endocrinol Metab. 2014;99(6):E1055-60. doi: 10.1210/jc.2013-3669. Epub 2014 Mar 20. PMID: 24650014. IF:6.310
DePaoli AM, Higgins LS, Henry RR, Mantzoros C, Dunn FL; INT131-007 Study Group. Can a selective PPARγ modulator improve glycemic control in patients with type 2 diabetes with fewer side effects compared with pioglitazone? Diabetes Care. 2014;37(7):1918-23. doi: 10.2337/dc13-2480. Epub 2014 Apr 10. PMID: 24722496. IF:8.57
Huh JY, Dincer F, Mesfum E, Mantzoros CS. Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans. Int J Obes (Lond). 2014;38(12):1538-44. doi: 10.1038/ijo.2014.42. Epub 2014 Mar 11. PMID: 24614098. IF:5.386
Anastasilakis AD, Polyzos SA, Saridakis ZG, Kynigopoulos G, Skouvaklidou EC, Molyvas D, Vasiloglou MF, Apostolou A, Karagiozoglou-Lampoudi T, Siopi A, Mougios V, Chatzistavridis P, Panagiotou G, Filippaios A, Delaroudis S, Mantzoros CS. Circulating irisin in healthy, young individuals: day-night rhythm, effects of food intake and exercise, and associations with gender, physical activity, diet, and body composition. J Clin Endocrinol Metab. 2014;99(9):3247-55. doi: 10.1210/jc.2014-1367. Epub 2014 Jun 10. PMID: 24915120. IF:6.310
Huh JY, Mougios V, Kabasakalis A, Fatouros I, Siopi A, Douroudos II, Filippaios A, Panagiotou G, Park KH, Mantzoros CS. Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation. J Clin Endocrinol Metab. 2014;99(11):E2154-61. doi: 10.1210/jc.2014-1437. Epub 2014 Aug 13.PMID: 25119310. IF:6.310
Foo JP, Polyzos SA, Anastasilakis AD, Chou S, Mantzoros CS. The effect of leptin replacement on parathyroid hormone, RANKL-osteoprotegerin axis, and Wnt inhibitors in young women with hypothalamic amenorrhea. J Clin Endocrinol Metab. 2014;99(11):E2252-8. doi: 10.1210/jc.2014-2491. Epub 2014 Aug 22. PMID: 25148234. IF:6.310
Farr OM, Fiorenza C, Papageorgiou P, Brinkoetter M, Ziemke F, Koo BB, Rojas R, Mantzoros CS. Leptin therapy alters appetite and neural responses to food stimuli in brain areas of leptin-sensitive subjects without altering brain structure. J Clin Endocrinol Metab. 2014;99(12):E2529-38. doi: 10.1210/jc.2014-2774. PMID: 25279500. IF:6.310
Foo JP, Aronis KN, Chamberland JP, Paruthi J, Moon HS, Mantzoros CS. Fibroblast Growth Factor 21 Levels in Young Healthy Females display Day/Night Variation and are increased in response to Short Term Energy Deprivation through a Leptin-independent Pathway. Diabetes Care. 2013;36(4):935-42. PMID: 23193213; PMCID: PMC3609498. IF:8.57
Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, Mantzoros CS. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism. 2012;61(12):1725-38. doi: 10.1016/j.metabol.2012.09.002. Epub 2012 Sep 25. PMID: 23018146; PMCID: PMC3614417. IF:3.611
Kizer JR, Benkeser D, Arnold AM, Mukamal KJ, Ix JH, Zieman SJ, Siscovick DS, Tracy RP, Mantzoros CS, deFilippi CR, Newman AB, Djousse L. Associations of Total and High-Molecular-Weight Adiponectin with All-cause and Cardiovascular Mortality in Older Persons: The Cardiovascular Health Study. Circulation. 2013; 126(25):2951-61. PMID: 23159554. IF:14.948
Moon HS, Dincer F, Mantzoros CS. Amylin-induced downregulation of hippocampal neurogenesis is attenuated by leptin in a STAT3/AMPK/ERK-dependent manner in mice. Diabetologia. 2013 ;56(3):627-34. PMID: 23224631. IF:6.88
Matarese G, La Rocca C, Moon HS, Huh JY, Brinkoetter MT, Chou S, Perna F, Greco D, Kilim HP, Gao C, Arampatzi K, Wang Z, Mantzoros CS. Selective capacity of metreleptin administration to reconstitute CD4+ T-cell number in females with acquired hypoleptinemia. Proc Natl Acad Sci U S A. 2013;110(9):E818-27. PMID: 23382191; PMCID: PMC3587204. IF:9.81
Discacciati A, Wolk A, Mantzoros CS. Coffee consumption and risk of localized, advanced and fatal prostate cancer: a population-based prospective study. Ann Oncol. 2013;24(7):1912-8. PMID: 23508823. IF:6.578
Dalamaga M, Chou SH, Shields K, Papageorgiou P, Polyzos SA, Mantzoros CS. Leptin at the Intersection of Neuroendocrinology and Metabolism: Current Evidence and Therapeutic Perspectives. Cell Metab. 2013;18(1):29-42. PMID: 23770129. IF:16.747
Moon HS, Dalamaga M, Kim SY, Polyzos SA, Hamnvik OP, Magkos F, Paruthi P, Mantzoros CS. Leptin’s Role in Lipodystrophic and Nonlipodystrophic Insulin-Resistant and Diabetic Individuals. Endocr Rev. 2013;34(3):377-412. PMID: 23475416; PMCID: PMC3660716. IF:19.358
Moon HS, Liu X, Nagel JM, Chamberland JP, Diakopoulos KN, Brinkoetter MT, Hatziapostolou M, Wu Y, Robson SC, Iliopoulos D, Mantzoros CS. Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. Gut. 2012 Jun 26.; 62(4):561-70.
Dalamaga M, Diakopoulos KN, Mantzoros CS. The role of adiponectin in cancer: a review of current evidence. Endocr Rev. 2012 Aug;33(4):547-94. Epub 2012 Apr 30.
Rejeski WJ, Ip EH, Bertoni AG, Bray GA, Evans G, Gregg EW, Zhang Q; Look AHEAD Research Group. Lifestyle change and mobility in obese adults with type 2 diabetes. N Engl J Med. 2012 Mar 29;366(13):1209-17.
Lee DH, Huang H, Choi K, Mantzoros C, Kim YB. Selective PPARγ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice. Am J Physiol Endocrinol Metab. 2012 Mar;302(5):E552-60. doi: 10.1152/ajpendo.00569.2011. Epub 2012 Jan 3.
Kang ES, Magkos F, Kim BS, Zhai R, Su L, Kim YS, Christiani DC, Lee HC, Mantzoros CS. Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients. J Clin Endocrinol Metab. 2012 Jan;97(1):E129-35. Epub 2011 Nov 2.
Moon HS, Chamberland JP, Aronis K, Tseleni-Balafouta S, Mantzoros CS. Direct role of adiponectin and adiponectin receptors in endometrial cancer: in vitro and ex vivo studies in humans. Mol Cancer Ther. 2011 Dec; 10(12):2234-43. Epub 2011 Oct 6.
Moragianni VA, Aronis KN, Chamberland JP, Mantzoros CS. Short-term energy deprivation alters activin and follistatin but not inhibin B levels of lean healthy women in a leptin-independent manner. J Clin Endocrinol Metab. 2011 Dec; 96(12):3750-8. Epub 2011 Sep 14.
Brinkoetter M, Magkos F, Vamvini M, Mantzoros CS. Leptin treatment reduces body fat but does not affect lean body mass or the myostatin-follistatin-activin axis in lean hypoleptinemic women. Am J Physiol Endocrinol Metab. 2011 Jul; 301(1):E99-E104. Epub 2011 Apr 19.
Moon HS, Matarese G, Brennan AM, Chamberland JP, Liu X, Fiorenza CG, Mylvaganam GH, Abanni L, Carbone F, Williams CJ, De Paoli AM, Schneider BE, Mantzoros CS. Efficacy of metreleptin in obese patients with type 2 diabetes: cellular and molecular pathways underlying leptin tolerance. Diabetes.2011 Jun;60(6):1647-56.
Chou SH, Chamberland JP, Liu X, Matarese G, Gao C, Stefanakis R, Brinkoetter MT, Gong H, Arampatzi K, Mantzoros CS. Leptin is an effective treatment for hypothalamic amenorrhea. Proc Natl Acad Sci USA. 2011 Apr 19;108(16):6585-6590. Epub 2011 Apr 4.
Stuebe AM, Mantzoros C, Kleinman K, Gillman MW, Rifas-Shiman S, Gunderson EP, Rich-Edwards J. Duration of lactation and maternal adipokines at three years postpartum. Diabetes. 2011 Apr;60(4):1277-85. Epub 2011 Feb 24.
Choi KM, Yannakoulia M, Park MS, Cho GJ, Kim JH, Lee SH, Hwang TG, Yang SJ, Kim TN, Yoo HJ, Baik SH, Kim SM, Mantzoros CS. Serum adipocyte-fatty acid binding protein, retinol binding protein 4, and adiponectin levels in relation to the development of metabolic syndrome in Korean boys: A 3-year long prospective cohort study. Am J Clin Nutr. 2011 Jan;93(1):19-26. Epub 2010 Nov 24.
Moon HS, Chamberland J, Diakopoulos K, Fiorenza C, Ziemke F, Schneider B, Mantzoros C. Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues; in vitro and ex vivo studies in humans. Diabetes Care. 2010 Jan;34(1):132-8. Epub 2010 Sep 24.
Kotsopoulos J, Tworoger SS, Campos H, Chung FL, Clevenger CV, Franke AA, Mantzoros CS, Ricchiuti V, Willett WC, Hankinson SE, Eliassen AH. Reproducibility of plasma and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health Studies. Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):938-46. Epub 2010 Mar 23.
Scheer FAJL, Chan JL, Fargnoli J, Chamberland J, Arampatzi K, Shea SA, Blackburn GL, Mantzoros CS. Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions. Diabetologia. 2010 Nov;53(11):2401-5. Epub 2010 Aug 12.
Friberg E, Orsini N, Mantzoros CS, Wolk A. Alcohol intake and endometrial cancer risk: a meta-analysis of prospective studies. Br J Cancer. 2010 Jun 29;103(1):127-31.
Taveras EM, Rifas-Shiman SL, Rich-Edwards JW, Gunderson EP, Stuebe AM, Mantzoros CS. Association of Maternal Short Sleep Duration With Adiposity and Cardiometabolic Status at 3 Years Postpartum. Obesity (Silver Spring). 2010 May 20. [Epub ahead of print]
Sun Q, Cornelis MC, Kraft P, Qi L, van Dam RM, Girman CJ, Laurie CC, Mirel DB, Gong H, Sheu CC, Christiani DC, Hunter DJ, Hu FB, Mantzoros CS. Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels. Hum Mol Genet. 2010 May 1;19(9):1846-55.
Ruschke K, Fishbein L, Dietrich A, Klöting N, Tönjes A, Oberbach A, Fasshauer M, Jenkner J, Schön MR, Stumvoll M, Blüher M, Mantzoros CS. Gene expression of PPAR{gamma} and PGC-1{alpha} in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial effects of physical training. Eur J Endocrinol. 2010 Mar;162(3):515-23. Epub 2009 Dec 4.
Brennan AM, Sweeney LL, Liu X, Mantzoros CS. Walnut consumption increases satiation but has no effect on insulin resistance or the metabolic profile over a 4 day period. Obesity 2010 Jun; 18(6):1176-82.
Fung TT, Rexrode KM, Mantzoros CS, Manson JE, Willett WC, Hu FB. Mediterranean diet and incidence and mortality of coronary heat disease and stroke in women. Circulation 2009 Feb 17; 119: 1067-8.
Scheer F, Hilton M, Mantzoros CS, Shea S. Adverse metabolic and cardiovascular consequences of circadian misalignment. PNAS. 2009; 106 (11) 4453-8.
Ligibel JA, Giobbie-Hurder A, Olenczuk A, Campbell N, Salinardi N, Winer EP, Mantzoros CS. Impact of a Mixed Strength and Endurance Exercise Intervention on Levels of Adiponectin, High Molecular Weight Adiponectin and Leptin in Breast Cancer Survivors. Cancer Causes and Control 2009 Oct;20(8):1523-8.
Brennan AM, Lee JH, Tsiodras S, Chan JL, Doweiko J, Chimienti SN, Wadhwa SG, Karchmer AW, Mantzoros CS. r-metHuLeptin improves highly active antiretroviral therapy-induced lipoatrophy and the metabolic syndrome, but not through altering circulating IGF and IGF-binding protein levels: observational and interventional studies in humans. Eur J Endo 2009; 160(2):173-6.
View a complete list of Dr. Mantzoros’ publications here