Publications

Kahn Research Publications

Please click on the publication title to view it online at PubMed.

2016

Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 inhibits AMPKα2 through phosphorylation of Serine 491 and impairs insulin signaling in skeletal muscle cells . J Biol Chem. 2016, 291:5664-5675.

Zhang T, Chen S, Syed I, Ståhlman M, Kolar MJ, Homan EA, Chu Q, Smith U, Borén J, Kahn BB*, Saghatelian, A*. A liquid chromatography-mass spectrometry-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids (FAHFAs) . Nature Protocols 2016, 11:747-763. *Co-senior authors

Parsons WH, Kolar MJ, Kamat SS, Cognetta III AB, Hulce JJ, Saez E, Kahn BB*, Saghatelian A*, Cravatt BF*. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs . Nature Chemical Biology 2016, 12:367-372. *Co-senior authors

Moraes-Vieira PM, Castoldi A, Aryal P, Wellenstein K, Peroni OD, Kahn BB. Antigen presentation and T-cell activation are critical for RBP4-induced insulin resistance . Diabetes 2016, 65:1317-1327.

Vazirani RP, Verma A, Sadacca LA, Buckman MS, Picatoste B, Beg M, Torsitano C, Bruno JH, Patel RT, Simonyte K, Camporez JP, Moreira G, Falcone DJ, Accili D, Elemento O, Shulman GI, Kahn BB, McGraw TE. Disruption of adipose Rab 10-dependent insulin signaling causes hepatic insulin resistance . Diabetes 2016. (In press).

Kong D, Dagon Y, Campbell JN, Guo Y, Yang Z, Yi X, Aryal P, Wellenstein K, Kahn BB*, Sabatini BL*, Lowell BB*. A postsynaptic AMPKàp2-activated kinase pathway drives fasting-induced synaptic plasticity in AgRP neurons. Neuron 2016. (In press). *Co-senior authors

Moraes-Vieira PM, Saghatelian A, Kahn BB. GLUT4 expression in adipocytes regulates de novo lipogenesis and levels of a novel class of lipids with antidiabetic and anti-inflammatory effects. Diabetes 2016, 65. (In press).

Lee S-A, Yuen JJ, Jiang H, Kahn BB, Blaner WS. Adipocyte-specific over-expression of retinol-binding protein 4 (RBP4) causes hepatic steatosis in mice . Hepatology 2016. (In press).

2015

Kraus D, Yang Q, Kahn BB. Lipid extraction from mouse feces . Bio Protoc. 2015, 5:pii: e1375.

Kahn BB. Miracles of modern medicine. Voices. Women in Metabolism: Part I. Cell Metabolism 2015, 21:654.

Dodd G, Descherf S, Loh K, Simonds SE, Wiede F, Balland E, Merry TL, Münzberg-Gr & uuml ning H, Zhang Z-Y, Kahn BB, Neel BG, Bence KK, Andrews ZB, Cowley MA, Tiganis T. Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell 2015, 160:88-104.

Zemany L, Bhanot S, Peroni OD, Murray SF, Moraes-Vieira PM, Castoldi A, Manchem P, Guo S, Monia BP, Kahn BB. Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice. Diabetes 2015, 64:1603-1614.

Kraus BJ, Sartoretto JL, Polak P, Hosooka T, Shiroto T, Eskurza I, Lee S-A, Jian H. Michel T, Kahn BB Novel role for retinol-binding protein 4 in the regulation of blood pressure. FASEB J 2015, 29:3133-3140.

insulin act on POMC neurons to promote the browning of white fat. Cell 2015, 160:88-104.

Kraus BJ, Sartoretto JL, Polak P, Hosooka T, Shiroto T, Eskurza I, Lee S-A, Jian H. Michel T, Kahn BB. Novel role for retinol-binding protein 4 in the regulation of blood pressure. FASEB J 2015, 29:3133-3140.

2014

Guzman J, Jaurequi AN, Merscher-Gomez S, Maiguel D, Mursean C, Mitrofanova A, Diez-Sampedro A, Szust J, Yoo TH, Villarreal R, Pedigo C, Molano RD, Johnson K, Kahn BB, Hartleben B, Huber TB, Saha J, Burke GW, Abel ED, Brosius FC, Fornoni A. Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy. Diabetes 2014, 63:701-714.

Zemany L, Kraus BJ, Norseen J, Saito T, Peroni OD, Johnson RL, Kahn BB Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo. Mol Cell Biol 2014, 34:1170-1186.

Moraes-Vieira PM, Yore MM, Dwyer PM, Syed I, Aryal P, Kahn BB. RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metabolism 2014, 19:512-526.

Kraus D*, Yang Q*, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Yang Y-c, Chen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature 2014, 508:258-262.

Chiappini F*, Catalano KJ*, Lee J, Peroni OD, Lynch J, Dhaneshwar AS, Wellenstein K, Sontheimer A, Neel BG, Kahn BB Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice. J Clin Invest 2014, 124:3781-3792.

Yore MM*, Syed I*, Moraes-Vieira PM, Zhang T, Herman MA, Homan E, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar A, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell 2014, 159:318-332.

Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A. Data-driven synthesis of proteolysis-resistant peptide hormones. J. Amer. Chem. Soc. 2014, 136:17710-17713.

2013

Kahn BB , Minokoshi Y. Leptin, GABA, and glucose control. Cell Metabolism. 2013, 18:304-306.

Lee K, Russell S, Ussar S, Boucher J, Vernochet C, Mori M, Smyth G, Rourk M, Cederquist C, Rosen ED, Kahn BB, Kahn CR. Lessons on conditional gene targeting in mouse adipose tissue. Diabetes 2013, 62:864-874.

Wu N, Zheng B, Shaywitz A, Dagon Y, Tower C, Bellinger G, Shen C-H, Wen J, Asara J, McGraw TE, Kahn BB, Cantley LC. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Molecular Cell 2013, 49:1167-1175.

Sun Q, Kiernan UA, Shi L, Phillips DA, Kahn BB, Hu FB, Manson JA, Albert CM, Rexrode KM. Plasma retinol-binding protein 4 (RBP4) levels and risk of coronary heart disease: a prospective analysis among women in the nurses' health study. Circulation 2013, 127:1938-1947.

Miraldi ER, Friedline RH, Johnson H, Sharfi H, Zhang T, Lau KS, Hagis KM, Yaffe M, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integrative Biology 2013, 5:940-963.

Kurland IJ, Accili D, Burant C, Fischer SM, Kahn BB, Newgard CB, Ramagiri S, Ronnett GV, Ryals JA, Sanders M, Shambaugh J, Shockor J, Gross SS. Application of combined omics platforms to accelerate biomedical discovery in diabesity. Ann N Y Acad Sci. 2013, 1287:1-16.

2012

Herman MA, Kahn BB. Adipose tissue de novo lipogenesis. Unanticipated benefits in health and disease. ASBMB Today. February 2012, 30-32.

Yang Q, Eskurza I, Kiernan UA, Phillips DA, Bluher M, Graham TE, Kahn BB. Quantitative measurement of full-length and C-terminal proteolyzed RBP4 in serum of normal and insulin-resistant humans using a novel mass spectrometry immunoassay (qMISA).Endocrinology 2012, 153(3):1519-1527.

Herman MA, Peroni OD, Villoria J, Schön MR, Abumrad NA, Blüher M, Klein S, Kahn BB A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature 2012, 484:333-338.

Owen CD, Czopek AJ, Agouni A, Judson RN, Göransson O, Bence KK, Rosen ED, Kahn BB, Neel BG, Mody N, Delibegović M. Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis. PLoS One 2012, 7:e32700.

Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, Usheva A, Davis RJ, Smith U, Kahn BB. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol 2012, 32:2010-2019.

Kawashima J, Alquier T, Tsuji Y, Peroni OD, Kahn BB Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia. PLoS One 2012, 7:e36335.

Dagon Y, Hur E, Zheng B, Cantley LC, Kahn BB p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake. Cell Metabolism 2012, 16:104-112.

Hammarstedt A, Graham TE, Kahn BB. Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells. Diabetol Metab Syndr. 2012, 4:42.

Myers Jr MG, Heymsfield SB, Haft C, Kahn BB, Laughlin M, Leibel RL, Tschöp MH, Yanovski JA. Challenges and opportunities of defining clinical leptin resistance. Cell Metabolism 2012, 15:150-156.

2011

Noriega LG, Feige JN, Canto C, Yu, J, Herman MA, Yamamoto H, Mataki C, Kahn BB, Auwerx J. CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. EMBO Reports, 2011, 12(10):1069-76.

Loh K, Fukushima A, Zhang X, Galic S, Briggs D, Enriori PJ, Simonds S, Wiede F, Reichenbach A, Hauser C, Sims NA, Bence KK, Zhang S, Zhang ZY, Kahn BB, Neel BG, Andrews ZB, Cowley MA, Tiganis T. Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metabolism, 2011, 14(5):684-699.

Tschöp MH, Speakman JR, Arch JRS, Auwerx J, Brüning JC, Chan L, Eckel R, Farese Jr. RV, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier, E, Müller TD, Muenzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E. A guide to analysis of mouse energy metabolism. Nature Methods 2011, 9(1):57-63.

Pulinilkunnil T, He H, Kong D, Asakura K, Peroni OD, Lee A, Kahn BB. Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo. J Biol Chem 2011, 286:8798-8809.

Pulinilkunnil T, He H, Kong D, Asakura K, Peroni OD, Lee A, Kahn BB. Adrenergic regulation of AMP-activated protein kinase in BAT in vivo. J Biol Chem 2011. In press. DOI 10.1074/jbc.M111.218719.

2010

Herman M, She P, Peroni OD, Lynch CJ, Kahn BB. Adipose tissue branched-chain amino acid (BCAA) metabolism modulates circulating BCAA levels. J Biol. Chem. 2010, 285:11348-11356.

Yang Z, Kahn BB, Shi H, Xue BZ. Macrophage alpha1 AMP-activated protein kinase (alpha1-AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J Biol. Chem. 2010, 285:19051-19059.

Matsuo K, Delibegovic M, Matsuo I, Nagata N, Liu S, Bettaieb A, Yannan X, Araki K, Yang W, Kahn BB, Neel BG, Haj FG. Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2. J Biol Chem. 2010. In press. DOI 10.1074/jbc.M110.153734.

Kraus D, Herman MA, Kahn BB. Leveraging leptin for type 1 diabetes? Proc Nat Acad Sciences. 2010, 107:4793-4794.

Kahn BB , McGraw TE. Rosiglitozone, PPARγ and type 2 diabetes. New England Journal of Medicine. 2010, 363:2667-2669.

2009

Goodman E, Graham TE, Dolan LM, Daniels SR, Goodman ER, Kahn BB. The relationship of retinol binding protein 4 to changes in insulin resistance and cardiometabolic risk in overweight black adolescents. J. Pediatr. 2009, 154:67-73.

Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong E-G,, Cho Y-R, Kim JK, Kahn BB, Neel BG, Bence KK. Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced ER stress. Diabetes 2009, 58:590-599.

Xue B, Pulinikunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB. Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues. Mol. Cell. Bio. 2009, 29:4563-4573.

Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi G-P. Deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nature Medicine 2009, 15:940-945.

Hill J, Xu Y, Preitner F, Cho Y-R, Luo J, Balthasar N, Coppari R, Cantley L, Kahn BB, Zhao J, Elmquist J. PI3K signaling in hypothalamic POMC neurons contributes to the regulation of glucose homeostasis. Endocrinology 2009, 150:4874-4882.

Preitner F, Mody N, Graham TE, Peroni OD, Kahn BB. Long-term fenretinide treatment prevents high fat diet-induced obesity, insulin resistance and hepatic steatosis. Amer. J Physiol. Endo Metab 2009, 297:E1420-E1429

Jourdan M, Jaleel A, Karakelides H, Ford GC, Kahn BB, Nair S. Impact of type 1 diabetes and insulin treatment on plasma levels and fractional synthesis rate of retinol-binding protein 4. J. Clinical Endo and Metab. 2009, 94:5125-5130.

2008

Hammarstedt A, Pihlajamäki J, Graham TE, Kainulainen S, Kahn BB, Laasko M, Smith U. High circulating levels of RBP4 and mRNA levels of aP2, PGC-1 and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects. Journal of Internal Medicine 2008,263:440-449.

Mody N, Graham TE, Tsuji Y, Yang Q, Kahn BB. Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice. Amer. J Physiol: Endocrinol and Metabol 2008, 294:E785-E793.

Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB. Protein tyrosine phosphatase 1B (PTP1B) expression is induced by inflammation in vivo. J Biol. Chem. 2008, 283:14230-14241.

Krzyzanowska K, Zemany L, Krugluger W, Schernthaner GH, Mittermaver F, Schnack C, Rahman R, Brix J, Kahn BB, Schernthaner G. Serum concentrations of retinol-binding protein 4 in women with and without gestational diabetes. Diabetologia 2008, 51:1115-1122.

Enjyoji K, Kotani K, Thukral C, Blumel B, Sun X, Wu Y, Imai M, Friedman D, Csizmadia E, Bleibel W, Kahn BB, Robson SC. Deletion of Cd39/Entpd1 results in hepatic insulin resistance. Diabetes 2008, 57:2311-2320.

2007

Klöting N, Graham TE*, Berndt J, Kralisch S, Kovacs P, Wason CJ, Fasshauer M, Schön MR, Stumvoll M, Blüher M, Kahn BB. Serum retinol binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metabolism 2007, 6:79-87.

Kennedy AR, Pissios P, Out H. Xue B, Asakura K, Furukawa N, Marino FE Liu F, Kahn BB, Libermann T, Maratos-Flier, E. A high fat, ketogenic diet, induces a unique metabolic state in mice. Amer. J. Physiol. Endocrinology and Metabolism 2007, 292:E1724-E1739.

Graham TE, Kahn BB. Tissue-specific alterations of glucose transport and molecular mechanisms of intertissue communication in obesity and type 2 diabetes . Horm Metab Res. 2007 Oct;39(10):717-21.

Kovacs P, Geyer M, Berndt J, Klöting N, Graham TE, Böttcher Y, Enigk B, Tönjes A, Schleinitz D, Schön MR, Kahn BB, Blüher M, Stumvoll M. Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression. Diabetes. 2007 Dec;56(12):3095-100. Epub 2007 Aug 29.

Delibegovic M, Bence KK, Mody N, Hong EG, Ko HJ, Kim JK, Kahn BB, Neel BG. Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Mol Cell Biol. 2007 Nov;27(21):7727-34. Epub 2007 Aug 27.

Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi GP. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol. 2007 Aug;9(8):970-7. Epub 2007 Jul 22.

Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL, Shulman GI. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12587-94. Epub 2007 Jul 18.

Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, Houstis NE, Kahn BB, Rosen ED. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes. 2007 Oct;56(10):2533-40. Epub 2007 Jul 16.

Klöting N, Graham TE, Berndt J, Kralisch S, Kovacs P, Wason CJ, Fasshauer M, Schön MR, Stumvoll M, Blüher M, Kahn BB. Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab. 2007 Jul;6(1):79-87.

Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. J Biol Chem. 2007 Aug 17;282(33):23829-40. Epub 2007 Jun 1.

Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB, Jain MK. Regulation of gluconeogenesis by Krüppel-like factor 15. Cell Metab. 2007 Apr;5(4):305-12.

Balagopal P, Graham TE, Kahn BB, Altomare A, Funanage V, George D. Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation. J Clin Endocrinol Metab. 2007 May;92(5):1971-4. Epub 2007 Mar 6.

Kennedy AR, Pissios P, Otu H, Xue B, Asakura K, Furukawa N, Marino FE, Liu FF, Kahn BB, Libermann TA, Maratos-Flier E, Roberson R. A high-fat, ketogenic diet induces a unique metabolic state in mice. Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1724-39. Epub 2007 Feb 13. Erratum in: Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1846. Roberson, Russell [added].

Graham TE, Wason CJ, Blüher M, Kahn BB. Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia. 2007 Apr;50(4):814-23. Epub 2007 Feb 9.

Alquier T, Kawashima J, Tsuji Y, Kahn BB. Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia. Endocrinology. 2007 Mar;148(3):1367-75. Epub 2006 Dec 21.

2006

Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med. 2006 Aug;12(8):917-24. Epub 2006 Jul 16.

Herman MA, Kahn BB. Free in PMC Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest. 2006 Jul;116(7):1767-75. Review.

Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson PA, Smith U, Kahn BB. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 2006 Jun 15;354(24):2552-63.

Kahn BB , Myers MG Jr. mTOR tells the brain that the body is hungry. Nat Med. 2006 Jun;12(6):615-7. No abstract available.

Xue B, Kahn BB. AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol. 2006 Jul 1;574(Pt 1):73-83. Epub 2006 May 18. Review.

Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, Kahn BB. Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. J Biol Chem. 2006 Jul 14;281(28):18933-41. Epub 2006 May 10.

2005

Kim YB, Peroni OD, Aschenbach WG, Minokoshi Y, Kotani K, Zisman A, Kahn CR, Goodyear LJ, Kahn BB. Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism. Mol Cell Biol. 2005 Nov;25(21):9713-23.

Furukawa N, Ongusaha P, Jahng WJ, Araki K, Choi CS, Kim HJ, Lee YH, Kaibuchi K, Kahn BB, Masuzaki H, Kim JK, Lee SW, Kim YB. Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab. 2005 Aug;2(2):119-29.

Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab. 2005 Feb;1(2):107-19.

Kahn BB , Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 2005 Jan;1(1):15-25. Review.

Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005 Jul 21;436(7049):356-62.

Carvalho E, Kotani K, Peroni OD, Kahn BB. Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle. Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E551-61.

Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, Shiota M, Kesterson RA, Kahn BB, Magnuson MA. Deletion of PPAR{gamma} in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6207-12. Epub 2005 Apr 15.

Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005 Mar;25(6):2498-510.

Haj FG, Zabolotny JM, Kim YB, Kahn BB, Neel BG. Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice. J Biol Chem. 2005 Apr 15;280(15):15038-46. Epub 2005 Feb 7.

Galic S, Hauser C, Kahn BB, Haj FG, Neel BG, Tonks NK, Tiganis T. Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP. Mol Cell Biol. 2005 Jan;25(2):819-29.

Corbould A, Kim YB, Youngren JF, Pender C, Kahn BB, Lee A, Dunaif A. Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling. Am J Physiol Endocrinol Metab. 2005 May;288(5):E1047-54. Epub 2004 Dec 21.

Chan JL, Moschos SJ, Bullen J, Heist K, Li X, Kim YB, Kahn BB, Mantzoros CS. Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with relative leptin deficiency. J Clin Endocrinol Metab. 2005 Mar;90(3):1625-31. Epub 2004 Dec 21.

2004

Kotani K, Peroni OD, Minokoshi Y, Boss O, Kahn BB. GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization. J Clin Invest. 2004 Dec;114(11):1666-75.

Morroni M, Giordano A, Zingaretti MC, Boiani R, De Matteis R, Kahn BB, Nisoli E, Tonello C, Pisoschi C, Luchetti MM, Marelli M, Cinti S. Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland. Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16801-6. Epub 2004 Nov 19.

Patti ME, Kahn BB. Nutrient sensor links obesity with diabetes risk. Nat Med. 2004 Oct;10(10):1049-50.

Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB, Cantley LC. Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Mol Cell Biol. 2004 Jun;24(11):5080-7.

Bluher M, Patti ME, Gesta S, Kahn BB, Kahn CR. Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression. J Biol Chem. 2004 Jul 23;279(30):31891-901. Epub 2004 May 6.

Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferre P, Birnbaum MJ, Stuck BJ, Kahn BB. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature. 2004 Apr 1;428(6982):569-74.

Zabolotny JM, Haj FG, Kim YB, Kim HJ, Shulman GI, Kim JK, Neel BG, Kahn BB. Transgenic overexpression of PTP1B in muscle causes insulin resistance but overexpression with LAR does not additively impair insulin action. J Biol Chem. 2004 Mar 18 [Epub ahead of print].

Carvalho E, Schellhorn SE, Zabolotny JM, Martin S, Tozzo E, Peroni OD, Houseknecht KL, Mundt A, James DE, Kahn BB. GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and IRAP. J Biol Chem. 2004 Feb 24 [Epub ahead of print].

Bjorbaek C, Kahn BB. Leptin Signaling in the Central Nervous System and the Periphery. Recent Prog Horm Res. 2004;59(1):305-331.

Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, Neel BG, White MF. Islet-Sparing Effects of Protein Tyrosine Phosphatase-1b Deficiency Delays Onset of Diabetes in IRS2 Knockout Mice . Diabetes. 2004 Jan;53(1):61-66.

2003

Kim YB, Kotani K, Ciaraldi TP, Henry RR, Kahn BB. Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction. Diabetes. 2003 Aug;52(8):1935-42.

Burcelin R, Crivelli V, Perrin C, Da Costa A, Mu J, Kahn BB, Birnbaum MJ, Kahn CR, Vollenweider P and Thorens B. GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization. J. Clin. Invest. 2003;111:1555-1562.

Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003;299:572-574.

2002

Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Nagai R, Kimura S, Kahn BB and Kadowaki T. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Medicine 2002; 8:1-8.

Kim YB, Shulman GI, Kahn BB. Fatty acid infusion selectively impairs insulin action on Akt1 and PKCl/z ??but not on glycogen synthase kinase-3. J. Biol. Chem. 2002; 277: 32915-32922.

Choi CS, Kim YB, Lee FN, Zabolotny JM, Kahn BB, Youn JH. Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling. Amer. J. Physiol. 2002; 283:E233-240.

Bluher M, Michael MD, Peroni OD, Ueki K, Carter N, Kahn BB , Kahn CR. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Developmental Cell 2002; 3:25-38.

Zabolotny JM, Bence-Hanulec KK, Stricker-Krongrad A, Haj FG, Wang YP, Minokoshi Y, Kim Y-B, Elmquist JK, Tartaglia LA, Kahn BB*+ , Neel BG*. PTP1B regulates leptin signal transduction in vivo. Developmental Cell 2002; 2:489-495.

Kim YB, Ciaraldi TP, Kong A, Kim D, Chu N, Henry RR, Kahn BB. Troglitazone, but not metformin, restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110b protein levels in skeletal muscle of type 2 diabetic humans. Diabetes 2002; 51:443-448.

Minokoshi Y, Kim Y-B, Peroni OD, Fryer LGD, Muller C, Carling D, Kahn BB. Leptin stimulates fatty acid oxidation by activation of AMP-activated protein kinase. Nature 2002; 415:339-343.

Tanner CJ, Koves TR, Cortright RL, Pories WJ, Kim Y-B, Kahn BB, Dohm GL, Houmard JA. Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men. Amer. J. Physiol. Endocrinology and Metabolism 2002; 282:E147-E153.

2001

Larkin LM, Reynolds TH, Supiano MA, Kahn BB, Halter JB. Effect of aging and obesity on altered insulin responsiveness and GLUT4 glucose transporter content in skeletal muscle of Fischer 344X Brown Norway rats. J. of Gerontology: Biol. Sci. Med. Sci. 2001; 56: B486-492.

Kim JK, Zisman A, Peroni OD, Kotani K, Perret P, Zong H, Dong J, Kahn CR, Kahn BB, Shulman GI. The role of glucose toxicity in the development of diabetes in mice with muscle-specific inactivation of GLUT4. J. Clin. Invest. 2001; 108:153-160.

Dickson LM, Lingohr MK, McCuaig J, Hügl SR, Snow L, Kahn BB, Myers MG, Rhodes CJ. Differential activation of PKB and p70S6K by glucose and IGF-1 in pancreatic b-cells (INS-1). J. Biol. Chem. 2001; 276:21110-21120.

Zabolotny JM, Kim Y-B, Peroni OD, Kim JK, Pani MA, Boss O, Klaman LD, Kamatkar S, Shulman GI, Kahn BB+, Neel BG+. Overexpression of the leukocyte antigen-related (LAR) protein tyrosine phosphatase in muscle causes insulin resistance. Proc. National Academy of Science 2001; 98:5187-5192. (+corresponding authors)

Huppertz C, Fischer BM, Kim Y-B, Kotani K, Vidal-Puig A, Slieker LJ, Sloop KW, Lowell BB, Kahn BB. Uncoupling protein 3 increases glucose uptake in muscle cells through a phosphoinositide 3-kinase dependent mechanism. J. Biol. Chem. 2001; 276:12520-12529.

Kahn BB , Tomkins DF. Determination of acetochlor in technical and formulated products by capillary gas chromatography: PVM 5:1999. J AOAC Int. 2001 Mar-Apr;84(2):317-22.

Abel ED, Peroni O, Kim JK, Kim Y-B, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 2001; 409:729-733. (* contributed equally)

2000

Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol. 2000 Aug;20(15):5479-89.

Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, Kahn BB. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med. 2000 Aug;6(8):924-8.

Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology. 2000 Jul;141(7):2328-39.

Venable CL, Frevert EU, Kim YB, Fischer BM, Kamatkar S, Neel BG, Kahn BB. Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation. J Biol Chem. 2000 Jun 16;275(24):18318-26.

Rasmussen SK, Hansen L, Frevert EU, Cohen PT, Kahn BB, Pedersen O. Adenovirus-mediated expression of a naturally occurring Asp905Tyr variant of the glycogen-associated regulatory subunit of protein phosphatase-1 in L6 myotubes. Diabetologia. 2000 Jun;43(6):718-22.

Kim JK, Michael MD, Previs SF, Peroni OD, Mauvais-Jarvis F, Neschen S, Kahn BB, Kahn CR, Shulman GI. Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. J Clin Invest. 2000 Jun;105(12):1791-7.

Permana PA, Kahn BB, Huppertz C, Mott DM. Functional analyses of amino acid substitutions Arg883Ser and Asp905Tyr of protein phosphatase-1 G-subunit. Mol Genet Metab. 2000 Jun;70(2):151-8.

Kim YB, Peroni OD, Franke TF, Kahn BB. Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats. Diabetes. 2000 May;49(5):847-56.

Xie Z, Li H, Liu L, Kahn BB, Najjar SM, Shah W. Metabolic regulation of Na(+)/P(i)-cotransporter-1 gene expression in H4IIE cells. Am J Physiol Endocrinol Metab. 2000 Apr;278(4):E648-55.

1999

Abel ED, Kaulbach HC, Tian R, Hopkins JC, Duffy J, Doetschman T, Minnemann T, Boers ME, Hadro E, Oberste-Berghaus C, Quist W, Lowell BB, Ingwall JS, Kahn BB. Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J Clin Invest. 1999 Dec;104(12):1703-14.

Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest. 1999 Sep;104(6):733-41.

Oh ES, Gu H, Saxton TM, Timms JF, Hausdorff S, Frevert EU, Kahn BB, Pawson T, Neel BG, Thomas SM. Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2. Mol Cell Biol. 1999 Apr;19(4):3205-15.

Law BK, Norgaard P, Gnudi L, Kahn BB, Poulson HS, Moses HL. Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway. J Biol Chem. 1999 Feb 19;274(8):4743-8.

Kim YB, Zhu JS, Zierath JR, Shen HQ, Baron AD, Kahn BB. Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle. Diabetes. 1999 Feb;48(2):310-20.

1998

Frevert EU, Bjorbaek C, Venable CL, Keller SR, Kahn BB. Targeting of constitutively active phosphoinositide 3-kinase to GLUT4-containing vesicles in 3T3-L1 adipocytes. J Biol Chem. 1998 Sep 25;273(39):25480-7.

Kometiani P, Li J, Gnudi L, Kahn BB, Askari A, Xie Z. Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases. J Biol Chem. 1998 Jun 12;273(24):15249-56.

Sutherland C, Waltner-Law M, Gnudi L, Kahn BB, Granner DK. Activation of the ras mitogen-activated protein kinase-ribosomal protein kinase pathway is not required for the repression of phosphoenolpyruvate carboxykinase gene transcription by insulin. J Biol Chem. 1998 Feb 6;273(6):3198-204.

Zierath JR, Frevert EU, Ryder JW, Berggren PO, Kahn BB. Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes. Diabetes. 1998 Jan;47(1):1-4.

1997

Tozzo E, Gnudi L, Kahn BB. Amelioration of insulin resistance in streptozotocin diabetic mice by transgenic overexpression of GLUT4 driven by an adipose-specific promoter. Endocrinology. 1997 Apr;138(4):1604-11.

Zierath JR, Houseknecht KL, Gnudi L, Kahn BB. High-fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect. Diabetes. 1997 Feb;46(2):215-23.

Frevert EU, Kahn BB. Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes. Mol Cell Biol. 1997 Jan;17(1):190-8.

Gnudi L, Frevert EU, Houseknecht KL, Erhardt P, Kahn BB. Adenovirus-mediated gene transfer of dominant negative ras(asn17) in 3T3L1 adipocytes does not alter insulin-stimulated P13-kinase activity or glucose transport. Mol Endocrinol. 1997 Jan;11(1):67-76.

1996

Houseknecht KL, Mantzoros CS, Kuliawat R, Hadro E, Flier JS, Kahn BB. Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity. Diabetes. 1996 Nov;45(11):1638-43.

Magnan C, Gilbert M, Kahn BB. Chronic free fatty acid infusion in rats results in insulin resistance but no alteration in insulin-responsive glucose transporter levels in skeletal muscle. Lipids. 1996 Nov;31(11):1141-9.

Frevert EU, Kahn BB. Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states. Biochem J. 1996 Jun 15;316 ( Pt 3):865-71.

Houseknecht KL, Zhu AX, Gnudi L, Hamann A, Zierath JR, Tozzo E, Flier JS, Kahn BB. Overexpression of Ha-ras selectively in adipose tissue of transgenic mice. Evidence for enhanced sensitivity to insulin. J Biol Chem. 1996 May 10;271(19):11347-55.

Tozzo E, Kahn BB, Pilch PF, Kandror KV. Glut4 is targeted to specific vesicles in adipocytes of transgenic mice overexpressing Glut4 selectively in adipose tissue. J Biol Chem. 1996 May 3;271(18):10490-4.

Gnudi L, Jensen DR, Tozzo E, Eckel RH, Kahn BB. Adipose-specific overexpression of GLUT-4 in transgenic mice alters lipoprotein lipase activity. Am J Physiol. 1996 Apr;270(4 Pt 2):R785-92.

Gnudi L, Shepherd PR, Kahn BB. Over-expression of GLUT4 selectively in adipose tissue in transgenic mice: implications for nutrient partitioning. Proc Nutr Soc. 1996 Mar;55(1B):191-9. Review.

Gabbay RA, Sutherland C, Gnudi L, Kahn BB, O'Brien RM, Granner DK, Flier JS. Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway. J Biol Chem. 1996 Jan 26;271(4):1890-7.

1995

Susulic VS, Frederich RC, Lawitts J, Tozzo E, Kahn BB, Harper ME, Himms-Hagen J, Flier JS, Lowell BB. Targeted disruption of the beta 3-adrenergic receptor gene. J Biol Chem. 1995 Dec 8;270(49):29483-92.

Zierath JR, Nolte LA, Wahlstrom E, Galuska D, Shepherd PR, Kahn BB, Wallberg-Henriksson H. Carrier-mediated fructose uptake significantly contributes to carbohydrate metabolism in human skeletal muscle. Biochem J. 1995 Oct 15;311 ( Pt 2):517-21.

Frederich RC, Lollmann B, Hamann A, Napolitano-Rosen A, Kahn BB, Lowell BB, Flier JS. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest. 1995 Sep;96(3):1658-63.

Tozzo E, Shepherd PR, Gnudi L, Kahn BB. Transgenic GLUT-4 overexpression in fat enhances glucose metabolism: preferential effect on fatty acid synthesis. Am J Physiol. 1995 May;268(5 Pt 1):E956-64.

Gnudi L, Tozzo E, Shepherd PR, Bliss JL, Kahn BB. High level overexpression of glucose transporter-4 driven by an adipose-specific promoter is maintained in transgenic mice on a high fat diet, but does not prevent impaired glucose tolerance. Endocrinology. 1995 Mar;136(3):995-1002.

Vestergaard H, Weinreb JE, Rosen AS, Bjorbaek C, Hansen L, Pedersen O, Kahn BB. Sulfonylurea therapy improves glucose disposal without changing skeletal muscle GLUT4 levels in noninsulin-dependent diabetes mellitus subjects: a longitudinal study. J Clin Endocrinol Metab. 1995 Jan;80(1):270-5.

1994

Moran A, Pyzdrowski KL, Weinreb J, Kahn BB, Smith SA, Adams KS, Seaquist ER. Insulin sensitivity in cystic fibrosis. Diabetes. 1994 Aug;43(8):1020-6.

Rajan AS, Luo ZT, Kahn BB, Comstock JP, Cushman SW, Boyd AE 3rd. Do adipocytes contain high affinity sulfonylurea receptors. Endocrinology. 1994 Mar;134(3):1581-8.

1993

Andersen PH, Lund S, Schmitz O, Junker S, Kahn BB, Pedersen O. Increased insulin-stimulated glucose uptake in athletes: the importance of GLUT4 mRNA, GLUT4 protein and fibre type composition of skeletal muscle. Acta Physiol Scand. 1993 Dec;149(4):393-404.

Shepherd PR, Gnudi L, Tozzo E, Yang H, Leach F, Kahn BB. Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J Biol Chem. 1993 Oct 25;268(30):22243-6.

Andersen PH, Vestergaard H, Lund S, Vedel P, Junker S, Kahn BB, Pedersen O. The effect of intensive insulin therapy on the insulin-regulatable glucose transporter (GLUT4) expression in skeletal muscle in type 1 diabetes. Diabet Med. 1993 Oct;10(8):699-706.

Andersen PH, Lund S, Vestergaard H, Junker S, Kahn BB, Pedersen O. Expression of the major insulin regulatable glucose transporter (GLUT4) in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion. J Clin Endocrinol Metab. 1993 Jul;77(1):27-32.

Hughes VA, Fiatarone MA, Fielding RA, Kahn BB, Ferrara CM, Shepherd P, Fisher EC, Wolfe RR, Elahi D, Evans WJ. Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. Am J Physiol. 1993 Jun;264(6 Pt 1):E855-62.

Flier JS, Moller DE, Moses AC, O'Rahilly S, Chaiken RL, Grigorescu F, Elahi D, Kahn BB, Weinreb JE, Eastman R. Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance. J Clin Endocrinol Metab. 1993 Jun;76(6):1533-41.

Elahi D, McAloon-Dyke M, Clark BA, Kahn BB, Weinreb JE, Minaker KL, Wong GA, Morse LA, Brown RS, Shapiro ME, et al. Sequential evaluation of islet cell responses to glucose in the transplanted pancreas in humans. Am J Surg. 1993 Jan;165(1):15-22.

1992

Kahn BB , Pedersen O. Suppression of GLUT4 expression in skeletal muscle of rats that are obese from high fat feeding but not from high carbohydrate feeding or genetic obesity. Endocrinology. 1993 Jan;132(1):13-22.

Shepherd PR, Gould GW, Colville CA, McCoid SC, Gibbs EM, Kahn BB. Distribution of GLUT3 glucose transporter protein in human tissues. Biochem Biophys Res Commun. 1992 Oct 15;188(1):149-54.

Shepherd PR, Gibbs EM, Wesslau C, Gould GW, Kahn BB. Human small intestine facilitative fructose/glucose transporter (GLUT5) is also present in insulin-responsive tissues and brain. Investigation of biochemical characteristics and translocation. Diabetes. 1992 Oct;41(10):1360-5.

Pedersen O, Kahn CR, Kahn BB. Divergent regulation of the Glut 1 and Glut 4 glucose transporters in isolated adipocytes from Zucker rats. J Clin Invest. 1992 Jun;89(6):1964-73.

Kahn BB , Pedersen O. Tissue-specific regulation of glucose transporters in different forms of obesity. Proc Soc Exp Biol Med. 1992 Jun;200(2):214-7.

Kahn BB , Rosen AS, Bak JF, Andersen PH, Damsbo P, Lund S, Pedersen O. Expression of GLUT1 and GLUT4 glucose transporters in skeletal muscle of humans with insulin-dependent diabetes mellitus: regulatory effects of metabolic factors. J Clin Endocrinol Metab. 1992 May;74(5):1101-9.

Gould GW, Brant AM, Kahn BB, Shepherd PR, McCoid SC, Gibbs EM. Expression of the brain-type glucose transporter is restricted to brain and neuronal cells in mice. Diabetologia. 1992 Apr;35(4):304-9.

Frederich RC Jr, Kahn BB, Peach MJ, Flier JS. Tissue-specific nutritional regulation of angiotensinogen in adipose tissue. Hypertension. 1992 Apr;19(4):339-44.

1991

Tal M, Kahn BB, Lodish HF. Expression of the low Km GLUT-1 glucose transporter is turned on in perivenous hepatocytes of insulin-deficient diabetic rats. Endocrinology. 1991 Oct;129(4):1933-41.

Pedersen O, Kahn CR, Flier JS, Kahn BB. High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats. Endocrinology. 1991 Aug;129(2):771-7.

Kahn BB , Rossetti L, Lodish HF, Charron MJ. Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats. J Clin Invest. 1991 Jun;87(6):2197-206.

Kahn BB , Shulman GI, DeFronzo RA, Cushman SW, Rossetti L. Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression. J Clin Invest. 1991 Feb;87(2):561-70.

1990

Ploug T, Stallknecht BM, Pedersen O, Kahn BB, Ohkuwa T, Vinten J, Galbo H. Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle. Am J Physiol. 1990 Dec;259(6 Pt 1):E778-86.

Pedersen O, Bak JF, Andersen PH, Lund S, Moller DE, Flier JS, Kahn BB. Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM. Diabetes. 1990 Jul;39(7):865-70.

Thorens B, Flier JS, Lodish HF, Kahn BB. Differential regulation of two glucose transporters in rat liver by fasting and refeeding and by diabetes and insulin treatment. Diabetes. 1990 Jun;39(6):712-9.

Charron MJ, Kahn BB. Divergent molecular mechanisms for insulin-resistant glucose transport in muscle and adipose cells in vivo. J Biol Chem. 1990 May 15;265(14):7994-8000.

1983

Young SG, Hanson FW, Kahn BB. Pregnancy in a young woman with Buerger's disease. A case report. J Reprod Med. 1983 Oct;28(10):694-6.

Reviews, Chapters, and Editorials

Kahn BB , Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 2005 Jan;1(1):15-25. Review.

Alquier T, Kahn BB. Peripheral signals set the tone for central regulation of metabolism. Endocrinology. 2004 Sep;145(9):4022-4.

Collins S, Ahima RS, and Kahn BB. Biology of Adipocytes. In Joslin's Diabetes Mellitus 14th edition. CR Kahn, GC Weir, GL King, AC Moses, RJ Smith, AM Jacobson eds. Lippincott Williams and Wilkins, 2004 (in press).

Bjorbaek, C and BB Kahn. Leptin signaling in the central nervous system and the periphery. Recent Progress in Hormone Research, 2004 59:305-331.

Abel ED, Shepherd PR, Kahn BB. Glucose transporters and pathophysiologic states. In Diabetes Mellitus: A Fundamental and Clinical Text (3rd edition). DR LeRoith, JM Olefsky and SI Taylor eds., JP Lippincott Co., Philadelphia, PA. 2004. p.917-938.

Minokoshi Y, Kahn CR, Kahn BB. Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis. J Biol Chem. 2003 Sep 5;278(36):33609-12. Epub 2003 Jun 04. Review.

Minokoshi Y and Kahn BB. Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle. Biochem. Society Trans. 2003;31:196-201.

Kahn BB , Flier JS. Obesity and insulin resistance. J Clin Invest. 2000 Aug;106(4):473-81. Review.

Shepherd PR, Abel ED, Kahn BB. Glucose transporters and pathophysiologic states. In Diabetes Mellitus: A Fundamental and Clinical Text. DR LeRoith, JM Olefsky and SI Taylor eds., JP Lippincott Co., Philadelphia, PA. 2000.p. 627-641.

Shepherd PR, Kahn BB. Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus. N Engl J Med. 1999 Jul 22;341(4):248-57. Review.

Kahn BB , Rossetti L. Type 2 diabetes--who is conducting the orchestra? Nat Genet. 1998 Nov;20(3):223-5.

Kahn BB . Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance. Cell. 1998 Mar 6;92(5):593-6. Review.

Goodyear LJ, Kahn BB. Exercise, glucose transport, and insulin sensitivity. Annu Rev Med. 1998;49:235-61. Review.

Houseknecht KL, Kahn BB. Molecular mechanisms for insulin-stimulated glucose transport: Regulation of GLUT4 translocation. J Anim Sci. 1997;75 (sup. 1):32-45.

Kahn BB . Lilly lecture 1995. Glucose transport: pivotal step in insulin action. Diabetes. 1996 Nov;45(11):1644-54. Review.

Zierath JR, Houseknecht KL, Kahn BB. Glucose transporters and diabetes. Seminars in Cell and Developmental Biology. 1996. M. Mueckler ed. 7:295-307.

Abel ED, Shepherd PR, Kahn BB. Glucose transporters and pathophysiologic states. In Diabetes Mellitus: A Fundamental and Clinical Text. DR LeRoith, JM Olefsky and SI Taylor eds., JP Lippincott Co., Philadelphia, PA. 1996. p. 530-543.

Gnudi L, Kahn BB. Trasportatori di glucosio e diabetes. In Giornale Italiano di Diabetologia. 1995;15:131-139.

Abel ED, Houseknecht KL, Kahn BB. Recent advances in understanding the molecular basis for insulin stimulated glucose transport. In Current Opinions in Endocrinology and Diabetes. 1995;2:313-324.

Kahn BB . Dietary regulation of glucose transporter gene expression: tissue specific effects in adipose cells and muscle. J Nutr. 1994 Aug;124(8 Suppl):1289S-1295S. Review.

Shepherd PR and Kahn BB. Expression of the GLUT4 glucose transporter in diabetes. In Molecular Biology of Diabetes. B Draznin and D LeRoith eds., Humana Press Inc., Totowa, NJ. 1994. p. 529-546.

Shepherd PR and Kahn BB. Cellular defects in glucose transport: lessons from animal models and implications for human insulin resistance. In Insulin Resistance DE Moller ed., John Wiley and Sons, Ltd. Sussex, England. 1993. p. 253-281.

Kahn BB . Facilitative glucose transporters: regulatory mechanisms and dysregulation in diabetes. J Clin Invest. 1992 May;89(5):1367-74. Review.

Kahn BB . Regolazione dei trasportatori del glucosio negli stati di insulino resistenza. Il Diabete. March, 1992. p. 13-17.

Kahn BB . Alterations in glucose transporter expression and function in diabetes: mechanisms for insulin resistance. J Cell Biochem. 1992 Feb;48(2):122-8. Review.

Kahn BB . Role of glucose transporters in diabetes. In Diabetes 1991. H Rifkin, JA Colwell and SI Taylor eds. Elsevier Science Publishers, Amsterdam, 1991. p. 429-433.

Kahn BB , Flier JS. Regulation of glucose-transporter gene expression in vitro and in vivo. Diabetes Care. 1990 Jun;13(6):548-64. Review.

Kahn BB and Cushman SW. Regulation of glucose transport in diabetes. In Frontiers of Diabetes Research: Current Trends in Non-insulin-dependent Diabetes Mellitus. KGMM Alberti, RS Mazze, editors. Excerpta Medica, Amsterdam, 1989. p. 155-165.

Kahn BB and Cushman SW. Cell biology of insulin action on glucose transport and its perturbation in diabetes mellitus. In Diabetes Mellitus: Pathophysiology and Therapy. W. Creutzfeldt and P. Lefebvre, editors. Springer-Verlag, Heidelberg, Germany, 1989. p.94-106.

Kahn BB , Cushman SW. Cell biology of insulin's stimulatory action on glucose transport and its perturbation in altered metabolic states. Ann N Y Acad Sci. 1986;488:356-69. Review.

Kahn BB , Cushman SW. Subcellular translocation of glucose transporters: role in insulin action and its perturbation in altered metabolic states. Diabetes Metab Rev. 1985;1(3):203-27. Review.