Kahn Lab

Kahn Laboratory

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Our Major Research Interests

• Molecular mechanisms of insulin resistance.
• Molecular pathogenesis of type 2 diabetes.
• Pathogenesis of obesity.
• Insulin action, glucose transport, leptin action, metabolism.
• The adipocyte as an endocrine organ.

Recent Work

• Discovered new signaling pathway involved in leptin action - AMP activated protein kinase.
• Discovered importance of the Glut4 glucose transporter in adipocytes in whole body insulin action.
• Investigating the role of protein tyrosine phosphatase 1B and other phosphatases in insulin action and body weight regulation.
• Discovered that PTP1B regulates leptin signaling by dephosphorylating Jak 2.

For a complete listing of Dr. Kahn's publications, click here.