Clinical Neurophysiology Fellowship

The Adult EEG/Epilepsy Track of the Clinical Neurophysiology fellowship program offers focused training in various aspects of advanced clinical epileptology and electroencephalography. This is achieved through the following major rotations at BIDMC: the Epilepsy Monitoring Unit, continuous EEG monitoring in the ICU and epilepsy inpatient consultations, outpatient epilepsy clinic, and elective rotations (20%) in one of the following subspecialties: clinical neuromuscular disease with EMG/NCS, sleep, autonomic neurophysiology, and intraoperative neurophysiological monitoring. Some electives may be taken at Boston Children’s Hospital and Massachusetts General Hospital. Formal weekly teaching sessions at BIDMC include clinical neurophysiology didactic lectures, epilepsy didactic lectures, multidisciplinary surgical case conference, journal club, and EEG case review.

Epilepsy Fellowship

Comprehensive Epilepsy Program

The Comprehensive Epilepsy Program at Beth Israel Deaconess Medical Center (BIDMC) in Boston has been one of the preeminent clinical centers in the United States for the diagnosis and treatment of patients with seizures ever since it was established about 40 years ago. BIDMC has been designated a Level 4 center by the National Association of Epilepsy Centers, signifying the highest level of care available in the field.

BIDMC is at the forefront of the latest technological advances for seizure patients. As a leader in the treatment of seizure disorders and related diagnoses, the BIDMC Epilepsy Program includes multiple centers and clinics for more specialized care including: a First Seizure Clinic, a Women’s Health and Epilepsy program, and the most advanced therapeutic options for patients with drug-resistant epilepsy.

We are also the home of the Berenson-Allen Center for Noninvasive Brain Stimulation, a world leader in the development of brain modulation techniques that do not require surgery. We are one of the pioneers in the cutting-edge field of critical care EEG and offer the ability to perform continuous monitoring of brain function in patients who need intensive care.

Team

BIDMC's Epilepsy Program staff includes board-certified epileptologists, neurosurgical specialists in epilepsy-related surgical procedures, clinical neuropsychologists, neuropsychiatrists, social workers, and clinical epilepsy nurses. Staff members also collaborate with BIDMC's Cognitive Neurology Division, Neuroendocrinology, Neuroradiology, and Obstetric/Gynecology and specialists in Maternal Fetal Medicine.

Epilepsy Research

Research has always been central to the experience of the adult epilepsy/EEG fellows at BIDMC. The history of the program is grounded in a number of “firsts” in the field of epilepsy, particularly in neuroimaging, antiepileptic drug trials, and EEG technology. Currently our research portfolio comprises several broad areas: 1) basic and translational science, aimed at understanding the underlying causes of epilepsy; 2) clinical research, including both investigator-initiated projects and drug and device trials; 3) technology and innovation, particularly in high-density EEG and noninvasive brain stimulation methods; 4) computational research, using large datasets to investigate the natural history of epilepsy and the results of randomized controlled trials; and 5) outcomes and quality research, exemplified by our leadership in national consortia and networks. Adult epilepsy/EEG fellows are introduced to the wide variety of possible research projects available for them when they begin their fellowship, and are linked to research mentors at BIDMC or neighboring institutions depending on their interests.

Opportunities for Teaching

BIDMC takes pride in providing prominent teaching opportunities for those fellows interested in education, involving medical students at Harvard Medical School (HMS) and neurology residents in the BIDMC-Children’s residency program. Formal training in teaching is also offered through the academies of educators at HMS and BIDMC, the Harvard-Macy Institute, additional fellowship programs in medical education, and formal master’s degree programs, for those interested in a career in education.

Clinical Neurophysiology and Epilepsy Fellowship Application Information

All interested individuals must have completed an ACGME-accredited residency training program in either pediatric or adult neurology or a program in one of these specialties that is located in Canada and accredited by the RCPSC. Selected fellows will spend 1-2 years developing subspecialty expertise in clinical neurophysiology and epilepsy.

Application Process:
All interested candidates should submit the following documentation:

• Fellowship application
• Curriculum Vitae
• Personal Statement (One page essay describing your interests in epilepsy, experiences and career goals)
• Three letters of reference (including a letter from Residency Program Director)
• Certified copy of valid ECFMG Certificate (international medical graduates only)
• Copies of USMLE scores (international medical graduates only)
• Digital professional photo of yourself

Applications may be submitted electronically by email. Interviews are offered on a rolling basis.

Contact Information

Trudy Pang, MD
Director, Clinical Neurophysiology Fellowship and Adult Epilepsy Fellowship
Beth Israel Deaconess Medical Center
330 Brookline Avenue
Boston, MA 02215
Tel: 617-632-8930
Fax: 617-632-8931
Email: tpang@bidmc.harvard.edu

• Eligibility/Application Process
• Core Faculty
• Current Fellows
• Alumni
• Publications

Program Overview

The Center for Autonomic and Peripheral Nerve Disorders at Beth Israel Deaconess Medical Center offers a unique fellowship in clinical neurophysiology in which trainees gain mastery in the complex and growing field of autonomic disorders.

Autonomic impairments occur in many medical conditions, as well as central and peripheral neurologic disorders. This fellowship offers extensive clinical training in autonomic disorders, autonomic testing and autonomic neurophysiology. If interested, the opportunity exists to acquire skills for skin biopsy assessment of sensory and autonomic nerves.

This fellowship was pioneered by Dr. Roy Freeman in 1996 and was one of the first autonomic fellowships in the country. It is the only fellowship in autonomic disorders in Massachusetts. During training, fellows will learn the treatment and management of patients with:

• Multiple system atrophy
• Parkinson’s disease with dysautonomia
• Pure autonomic failure
• Lewy body disease
• Postural tachycardia syndrome
• Neurally-mediated syncope
• Orthostatic hypotension
• Diabetic and other peripheral and autonomic neuropathies
• Small fiber neuropathy

These conditions are often unrecognized and may be challenging to treat, resulting in vastly underserved patient populations. The Autonomic Fellowship at BIDMC provides outstanding clinical training, preparing neurologists to treat all of these disorders with an interdisciplinary approach.

This fellowship is part of a comprehensive BIDMC/Boston Children’s Hospital Clinical Neurophysiology fellowship program that provides training in all aspects of clinical neurophysiology. Fellows in this program participate in a jointly shared interdisciplinary neurophysiology lecture series. This also helps to establish a collaborative relationship with future colleagues. Additional training is also available in EMG/NCS, EEG and sleep disorders. This fellowship is heavily clinically based in the outpatient setting, but there are numerous opportunities for basic, clinical and translational research. Fellows are encouraged to pursue these and faculty mentorship is well established.

Eligibility/Application Process

A fellowship position is available for board certified or board eligible adult or pediatric neurologists. This fellowship is part of a one-year ACGME approved fellowship with board certification eligibility in clinical neurophysiology.

Applicants interested in applying should send a letter of their career goals and objectives as well as a curriculum vitae and three letters of reference to:

Roy Freeman, MD
Center for Autonomic and Peripheral Nerve Disorders
Department of Neurology
Beth Israel Deaconess Medical Center
Palmer 111
185 Pilgrim Rd.
Boston, MA 02215
Phone: 617-632-8454
Fax: 617-632-0852

Core Faculty

Roy Freeman, MD
Professor of Neurology
Director, Autonomic Fellowship

Christopher Gibbons, MD,
Associate Professor of Neurology
President, American Autonomic Society
Chair, American Academy of Neurology, Autonomic Section

Alexandra Hovaguimian, MD, Instructor in Neurology

Istvan Bonyhay, MD, PhD, Instructor of Neurology

Ben Illigens, MD, Instructor in Neurology

Ningshan Wang, PhD, Instructor in Neurology

Current Fellows

Ahmad Abuzinadah, MD
Abuzinadah graduated from King Abdulaziz University Medical school and had his neurology training at University of Calgary, where also received his Master's degree in medical education. He then moved to Kansas City, where he finished neuromuscular and clinical neurophysiology training at Kansas University and also received his degree in clinical and translational research. Abuzinadah has been named an Assistant Professor of Neurology at King Abdulaziz University in Jeddah, Saudi Arabia, where he plans to start a neuromuscular and autonomic program with both clinical and research programs.

Dong In Sinn, MD
Dong In Sinn received his medical degree and Master's degree of medical science at Seoul National University College of Medicine in South Korea. He trained in neurology at Seoul National University Hospital and Medical University of South Carolina. Upon completion of his training at BIDMC, he will join the Stanford autonomic disorders program as a clinical assistant professor.

Alumni

Clinical Fellows

2003-2004: Christopher Gibbons, MD
Associate Professor of Neurology, BIDMC

• Development of novel biomarkers for autonomic and peripheral neuropathies
• Characterization and treatment of diabetic and autonomic neuropathies.

2004-2005: Danielle Cherdak, MD
Assistant Professor of Neurology, Vanderbilt University

• Autonomic and general neurology

2005-2006: Renato Gonik, MD
practicing neurologist

• General clinical neurophysiology and autonomic neurology

2006-2007: Tatiana Nabioulina, MD
practicing neurologist

• Autonomic and general neurology

2007-2008: Lindsey Lair, MD
Instructor of Neurology, NYU Langone Medical Center

• Autonomic and general neurology

2008-2009: Krishna Mettu, MD
practicing neurologist

• Autonomic and general neurology

2009-2010: Daniel Callahan, MD
Neurologist, Cleveland Clinic

• Teaching autonomic testing & treatment of neuropathic pain

2010-2011: Jeff Liou, MD
Instructor in Neurology, Brigham and Woman’s Hospital

• Evaluation and management of autonomic disorders

2010-2013: Alexandra Hovaguimian, MD
Instructor in Neurology, Beth Israel Deaconess Medical Center

• Evaluation and management of autonomic disorders
• Evaluation and management of headache and craniofacial pain syndromes

2011-2012: Mitch Miglis, MD
Assistant Professor of Neurology, Stanford University

• Evaluation and management of autonomic disorders with a focus on the integration between autonomic function and sleep

2013-2014: Pearl Jones, MD
Assistant Professor of Neurology, UT San Antonio

• Evaluation and management of autonomic disorders

2014-2015: Jennifer Dinneen, MD
Clinical Fellow in Neurology

• Autonomic disorders
  Neuromuscular disorders
  Intra-operative monitoring

2015-2016: Dong-In Sinn, MD
Clinical Fellow in Neurology

• Learning autonomic testing and skin biopsy evaluation of intra-epidermal nerve fiber density

2015-2016: Ahmad Abuzinadah, MD
Clinical Fellow in Neurology

• Learning autonomic testing and skin biopsy evaluation of intra-epidermal nerve fiber density

Research Fellows

2006: Ningshan Wang, PhD
Instructor in Neurology, Harvard Medical School

• Development of novel immunohistochemical techniques for study of autonomic and peripheral nerve disorders

2006: Ben Illigens, MD
Instructor in Neurology, Harvard Medical School

• Study of autonomic neurophysiology in health and disease

2012-2014: Jenniffer Garcia, MD
Research Fellow in Neurology

• Study of autonomic function research techniques, study design and protocol development

2013-2014: Eun Hee Son, MD
Research Fellow in Neurology

• Evaluation of intra-epidermal nerve fiber density
• Study of cutaneous autonomic neurovascular structure and function

2015-2016: Bum Chun Suh, MD
Research Fellow in Neurology

• Study of cutaneous autonomic neurovascular structure and function in health and diabetes

2015-2016: Marcel Casasola, MD
Research Fellow in Neurology

• Study of diabetic neuropathy, autonomic neuropathy and neurodegeneration

Publications

Originals

1. Gibbons CH, Garcia J, Wang N, Shi L, Freeman R The diagnostic discrimination of cutaneous alpha-synuclein deposition in Parkinson disease. Neurology (In press)
2. Ziegler D, Low P, Freeman R, Tritschler H, Vinik A. Predictors of improvement and progression of diabetic polyneuropathy following treatment with α-lipoic acid for 4 years in the NATHAN 1 trial. Journal of Diabetes and Its Complications (In press)
3. Rao A, Bonyhay I, Dankwa, J; Baimas-George, M; Kneen, L; Ballatori, S; Freeman, R*; Adler, G*. Baroreflex Sensitivity Impairment During Hypoglycemia – Implications for Cardiovascular Control. Diabetes Diabetes. 2016; 65(1):209-15. PMID: 26438610 PMCID: PMC4686952
4. Freeman R, Emir B, Parsons B. Predictors of placebo response in peripheral neuropathic pain: insights from pregabalin clinical trials. J Pain Res. 2015;8:257-68 [PMID: 26082659]
5. Gibbons C, Freeman R. Clinical implications of delayed orthostatic hypotension – a 10 year follow up study. Neurology 2015;85:1362-1367. [PMID: 26400576]
6. Biaggioni I, Freeman R, Mathias CJ, Low PA, Hewitt A, Kaufmann H. Randomized-withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsive to droxidopa. Hypertension. 2015;65:101-7. [PMID: 25350981]
7. Gibbons C, Freeman R. Treatment induced neuropathy of diabetes: an acute, iatrogenic complication of diabetes. Brain. 2015; 138:43-52. [PMID: 25392197]
8. Freeman R. Wallace Mark S, Sweeney M, Backonja MM. Relationships among pain quality, pain impact, and overall improvement in patients with postherpetic neuralgia treated with gastroretentive gabapentin. Pain Medicine. 2015 (In press). [PMID:26115203]
9. Kaufmann H, Freeman R, Biaggioni I, Low PA, Pedder S, Hewitt A, Mauney J, Feirtag M, and Mathias CJ. Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo- controlled Phase 3 trial. Neurology 2014: 83:328-35. [PMCID:PMC4115605]
10. Low PA, Robertson D, Gilman S, Kaufmann H, Singer W, Biaggioni I, Freeman R, Perlman S, Hauser RA, Cheshire W, Lessig S, Vernino S, Mandrekar J, Dupont WD, Chelimsky T, Galpern WR. Efficacy and safety of rifampicin for multiple system atrophy: a randomized, double-blind, placebo-controlled trial. Lancet Neurology. 2014;13:268-75.
11. Gibbons CH, Bonyhay I, Benson A, Wang N, Freeman R. Structural and Functional Small Fiber Abnormalities in the Neuropathic Postural Tachycardia Syndrome. PLoS One 2013; 8(12): e84716. doi:10.1371/journal.pone.0084716 [PMCID:PMC3874039]
12. Freeman R, Baron R, Bouhassira D, Cabrera J, Birol E. Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs. Pain 2014;155:367-76. [PMID: 244725]
13. Wang N, Gibbons CH, Lafo J, Freeman R. Alpha-synuclein in cutaneous autonomic nerves. Neurology. 2013; 81:1604-10. [PMCID: PMC3806913]
14. Bonyhay I, Risk M, Freeman R. High-Pass Filter Characteristics of the Baroreflex – A Comparison of Frequency Domain and Pharmacological Methods. PLoS One 2013; 8(11): e79513. doi:10.1371/journal.pone.0079513[PMCID: PMC3828383]
15. Gibbons CH, Freeman R, Tecilazich F, Dinh T, Lyons TE, Gnardellis C, Veves A. The evolving natural history of neurophysiologic function in patients with well-controlled diabetes. J Peripher Nerv Syst. 2013; 18:153-61. [PMID: 23781962]
16. Zhang L, Rainka M, Freeman R, Harden RN, Bell CF, Chen C, Graff O, Harding K, Hunter S, Kavanagh S, Laurijssens B, Schwartzbach C, Warren S, McClung C. A randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of gabapentin enacarbil in subjects with neuropathic pain associated with postherpetic neuralgia (PXN110748). Journal of Pain. 2013; 14:590-603. [PMID: 23602345]
17. Harden RN, Freeman R, Rainka M, Zhang L, Bell C, Berges A et al. A Phase 2a, randomized, crossover trial of gabapentin enacarbil for the treatment of postherpetic neuralgia in gabapentin inadequate responders. Pain Medicine 2013; 12:1918-32. [PMID: 24102928]
18. Gibbons CH, Adler GK, Bonyhay I, Freeman R. Experimental hypoglycemia is a human model of stress-induced hyperalgesia. Pain 2012; 153: 2204-2209 [PMCID:PMC356339]
19. Siepmann T, Gibbons CH, Illigens B, Lafo JA, Brown CM, Freeman R. Quantitative Pilomotor Axon-Reflex Test – A Novel Test of Pilomotor Function. Arch Neurol. 2012; 69:1488-92 [PMCID: PMC3563419].
20. Kaufmann H, Malamut R; Norcliffe-Kaufmann L; Rosa R; Freeman R. The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale. Clinical Autonomic Research 2011; 1-12.
21. Gibbons CH, Centi J, Vernino S, Freeman R. Autoimmune autonomic ganglionopathy with reversible cognitive impairment. Arch Neurol. 2012;69:461-466 [PMCID: PMC3359761].
22. Ziegler D, Low PA, Litchy WJ, Boulton AJ, Vinik AI, Freeman R, Samigullin R, Tritschler H, Munzel U, Maus J, Schütte K, Dyck PJ. Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: The NATHAN 1 Trial. Diabetes Care (epub 2011)
23. Wang N, Gibbons CH, Freeman R. Novel immunohistochemical techniques using discrete signal amplification systems for human cutaneous peripheral nerve fiber imaging. Journal of Histochemistry & Cytochemistry. 2011;59:382-90 [PMCID: PMC3201146].
24. Gibbons C, Wang N, Freeman R. Capsaicin induces degeneration of cutaneous autonomic nerve fibers. Annals of Neurology 2010;68:888-98.
25. Gibbons C, Freeman R, Veves A. Diabetic Neuropathy: A cross sectional study of the relationships among test of neurophysiology. Diabetes Care 2010;12:2629-34.
26. Adler GK, Bonyhay I, Curren V, Waring E, Freeman R. Hypoglycemia increases aldosterone in a dose-dependent fashion. Diabetic Medicine 2010; 11:1250-5.
27. Gibbons C, Freeman R. Treatment Induced Diabetic Neuropathy: A reversible painful autonomic neuropathy. Annals of Neurology. 2010; 67:534-41.
28. Simpson DM, Schifitto, G, Clifford DB, Murphy, TK, Durso-De Cruz E, Glue P, Whalen E, Emir E, Scott, G, Freeman R. Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial. 2010;74:413-420
29. Gibbons C, Illigens B, Wang N, Freeman R. The quantification of sudomotor innervation: a comparison of 3 methods. Muscle and Nerve. 2010;42:112-9.
30. Adler GK, Bonyhay I, Waring E, Failing HJ, Dotson S, Freeman R. Antecedent hypoglycemia impairs autonomic cardiovascular function – implications for rigorous glycemic control. Diabetes 2009;58:1-8.

Reviews

31. Edwards RR, Dworkin R, Turk D, Angst M, Dionne R, Freeman R, Hansson P, Haroutounian S, Arendt-Nielsen L, Attal N, MD et al. Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations. Pain 2016 (In Press)
32. Taylor AM, Phillips K, Patel KV, Turk D, Dworkin RH, Beaton D, Clauw DJ, Gignac MAM, Markman JD, Williams DA, Bujanover S, Burke LB, Carr DB, Choy EH. et al. Assessment of physical function and participation in chronic pain clinical trials: IMMPACT/OMERACT recommendations. Pain 2016 (In Press).
33. Thakur S, Dworkin RH, Freeman R, Gorson KC, Herrmann DN, Pain in acquired inflammatory demyelinating polyneuropathies. Pain 2016 (In Press) [PMID: 26945234]
34. Finnerup NB, Haroutounian, S, Kamerman P, Baron R, Bennett DLH, Bouhassira D, Cruccu G, Freeman R, Hansson P, Nurmikko T, Raja S, Rice ASC; Serra J, Smith BH, Treede R-D,; Jensen TS. Neuropathic pain: An updated grading system for research and clinical practice. Pain 2016 (In press)
35. Dineen J. Freeman R. Autonomic Peripheral Neuropathy. Seminars in Neurology 2015; 35: 458-468.
36. Freeman R, Barosso F. Familial amyloid polyneuropathy. Current Opinion in Neurology 2016 (in Press)
37. van Hecke O, Kamerman P, Attal N, Baron R, Bjornsdottir G, Bennett DL, Bennett MI, Bouhassira D, Diatchenko L, Freeman R, Freynhagenk R, Haanpääm M, Jensen TS, Raja SN, Rice ASC, Seltzer Z, Yarnitsky D, Smith BH. Neuropathic pain phenotyping by international consensus (NeuroPPIC): a NeuPSIG systematic review, Delphi survey and expert panel recommendations. Pain 2015;156:2337-53.PMID: 2646932
38. Laurens B, Constantinescu R, Freeman R, Gerhard A, Jellinger K, Jeromin A, Krismer F, Mollenhauer B, Schlossmacher MG, Shaw LM, Verbeek MM, Wenning GK, Winge K, Zhang J, Meissner WG. Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative. Neurobiol Dis. 2015;80:29-41. [PMID: 25982836]
39. Freeman R. Syncope. In Harrison’s Principles of Internal Medicine. Nineteenth Edition. McGraw Hill Medical. 2015.
40. Freeman R. The puzzle of orthostatic tolerance in hereditary sensory and autonomic neuropathy, type IV. Ann Neurol. 2015; 77:741-2. [PMID: 25866260]
41. Freeman R. Diabetic autonomic neuropathy. Handbook of Clinical Neurology. 2014;126:63-79. [PMID: 25410215]
42. Höke A, Simpson DM, Freeman R. Designing innovative therapies for neuropathic pain: preclinical and early clinical development challenges. J Peripher Nerv Syst. 2014: Suppl 2:S28-9. PMID:25269739
43. Fillingim, R.B., Bruehl, S., Dworkin, R.H., Dworkin, S.F., Loeser, J.D., Turk, D.C., Widerstrom-Noga, E., Arnold, L., Bennett, R., Edwards, R.R., Freeman, R., Gewandter, J., Hertz, S., Hochberg, M., Krane, E., Mantyh, P.W., Markman, J., Neogi, T., Ohrbach, R., Paice, J., Porreca, F., Rappaport, B.A., Smith, S.M., Smith, T.J., Sullivan, M.D., Verne, G.N., Wasan, A.D. & Wesselmann, U. The ACTTION-American Pain Society Pain Taxonomy (AAPT): An evidence-based and multi-dimensional approach to classifying chronic pain conditions. J Pain. 2014;15:241-9. [PMID: 2458163]
44. Gibbons C, Cheshire W, Barboi A, Levine B, Olshansky B, Kinsella L, Claydon VE, Crandall C, Fink G, Joyner M, Macefield V, Norcliffe-Kaufmann L, Freeman R, Raj S, Stewart J, Sandroni P, Kaufmann H, Chelimsky T. Endovascular procedures for the treatment of autonomic dysfunction. Clin Auton Res. 2014;24:1-2. PMID: 24178965
45. Höke A, Simpson DM, Freeman R. Challenges in developing novel therapies for peripheral neuropathies. J Peripher Nerv Syst. 2013; 18:1-6. [PMID: 23521637
46. Freeman R. New and developing drugs for the treatment of pain in diabetic peripheral neuropathy. Curr Diab Rep. 2013;13:500-8 [PMID: 2377140]
47. Emir B, Amaratunga D, Beltangady M, Cabrera J, Freeman R, Madigan D, Nguyen H, Whalen E. Generating productive dialogue between consulting statisticians and their clients in the pharmaceutical and medical research settings. Open Access Medical Statistics. 2013:3 51–56
48. Schestatsky P, Simis M, Freeman R, Pascual-Leone A, Fregni F. Non-invasive brain stimulation and the autonomic nervous system. Clin Neurophysiol. 2013; 124:1716-28. [PMID: 23684898]
49. Backonja MM, Attal N, Baron R, Bouhassira D, Drangholt M, Dyck PJ, Edwards RR, Freeman R, Gracely R, Haanpaa MH, Hansson P, Hatem SM, Krumova EK, Jensen TS, Maier C, Mick G, Rice AS, Rolke R, Treede RD, Serra J, Toelle T, Tugnoli V, Walk D, Walalce MS, Ware M, Yarnitsky D, Ziegler D. Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus. Pain. 2013; 154:1807-19.
50. Freeman R, Chapleau MW. Testing the autonomic nervous system. Handbook of Clinical Neurology. 2013; 115: 115-36.
51. Freeman R. Objective evidence of autonomic dysfunction and the role of stress in the Gulf War syndrome. JAMA Neurol. 2013;70:158-9. doi: 10.1001/jamaneurol.2013.1494. PMID: 23407742
52. Freeman R. Pharmacotherapy of Neuropathic Pain. In: Simpson DM, McArthur JCM, Dworkin R, Editors. Neuropathic Pain: Mechanisms and Management. Oxford University Press. New York, NY. 2012.
53. Freeman R. Autonomic Peripheral Neuropathy. In Donofrio PD (ed) .Textbook of Peripheral Neuropathy Chapter 28 (421-438). Demos Medical (New York) 2012.
54. Gibbons CH, Freeman R. Cutaneous autonomic innervation – Assessment by skin biopsy In: Robertson D, , Biaggioni I, Burnstock G , Low PA, Paton JFR eds. Primer on the Autonomic nervous system. 3nd Edition. Academic Press, New York, 2011; 85:413-417.
55. Gibbons CH, Freeman R. Delayed orthostatic hypotension. In: Robertson D, , Biaggioni I, Burnstock G, Low PA, Paton JFR eds. Primer on the Autonomic nervous system. 3nd Edition. Academic Press, New York, 2011; 109:529-530.
56. Kempler P, Amarenco G, Freeman R, Frontoni S, Horowitz M, Stevens M, Low P, Pop-Busui R, Tahrani A, Tesfaye S, Várkonyi T, Ziegler D, Valensi P; on behalf of the Toronto Consensus Panel on Diabetic Neuropathy. Gastrointestinal autonomic neuropathy, erectile-, bladder- and sudomotor dysfunction in patients with diabetes mellitus: clinical impact, assessment, diagnosis, and management. Diabetes Metab Res Rev. 2011 (Epub)
57. Spallone V, Ziegler D, Freeman R, Bernardi L, Frontoni S, Pop-Busui R, Stevens M, Kempler P, Hilsted J, Tesfaye S, Low P, Valensi P; on behalf of the Toronto Consensus Panel on Diabetic Neuropathy. Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management. Diabetes Metab Res Rev. 2011 (Epub)
58. Bernardi L, Spallone V, Stevens M, Hilsted J, Frontoni S, Pop-Busui R, Ziegler D, Kempler P, Freeman R, Low P, Tesfaye S, Valensi P; on behalf of the Toronto Consensus Panel on Diabetic Neuropathy. Investigation methods for cardiac autonomic function in human research studies. Diabetes Metab Res Rev. 2011 (Epub)
59. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz I, Schondorff R, Stewart JM, van Dijk JG. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Autonomic Neuroscience – Basic and Clinical 2011;161:46-8.
60. Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, Lauria G, Malik RA, Spallone V, Vinik A, Bernardi L, Valensi P; Toronto Diabetic Neuropathy Expert Group. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010;33:2285-93.
61. Freeman R. Syncope. Chapter 20. In Harrison’s Principles of Internal Medicine. Eighteenth Edition. McGraw Hill Medical. 2011

Applicants can apply to either the one-year ACGME accredited fellowships in CNP/EMG or Neuromuscular Medicine.  For more detailed information and application instructions, please click here.

Program Overview

Boston Children’s Hospital has a longstanding, time-honored program in clinical neurophysiology and epilepsy in conjunction with the BIDMC fellowship. Fellows rotate between the Epilepsy Monitoring Unit, Epilepsy Inpatient Consult/ICU/EEG service, outpatient/ambulatory EEG service with epilepsy clinic, and electives.

Multiple electives are available in highly selected areas with research opportunities. These include:

• Epilepsy genetics
• Neuromodulation/brain stimulation
• MEG
• Computational neurophysiology
• Neuroimaging lab
• Clinical trials
• Ketogenic diet
• Metabolic epilepsies
• Neuropsychology
• Pediatric sleep disorders

A second year for focused research is often available.

Eligibility/Application

Eligible candidates for the Children’s Hospital positions will have successfully completed prerequisite residency training with board eligibility in pediatric neurology. Please contact Dr. Jurriaan Peters for more information.

Jurriaan Peters MD, Training Director
Division of Epilepsy & Clinical Neurophysiology
Boston Children’s Hospital
300 Longwood Avenue
Boston, MA 02115
Phone: 617-355-2413
Fax: 617-730-0463

Leadership & Core Faculty

Phillip Pearl, MD, Division Director
Tobias Loddenkemper, MD, Director of Clinical Research
Ann Poduri, MD, Director of Epilepsy Genetics
Alex Rotenberg, MD, Director of Neuromodulation
Mark Libenson, MD, Director of EEG Laboratory
Ann Bergin, MD, Director of Ketogenic Diet Program
Jurriaan Peters, MD, Director of Computational Neurophysiology
Arnold Sansevere, MD, Director of ICU Monitoring
Chellamani Harini, MD, Director of Infantile Spasms Program
Max Takeoka, MD, Neurophysiology Research
Jeffrey Bolton, MD, Epilepsy Surgery Program
Archana Patel, MD, International Neurology and Epilepsy Program