Novak SAFE Laboratory

Syncope and Falls in the Elderly Laboratory (SAFE Lab)

The Safe Program mission is to determine factors that set the stage for decline in brain function and loss of independence in older adults. We study the mechanisms by which clinical, environmental, and hereditary factors lead to age-related disorders, abnormalities in systemic regulation and functional decline in older adults.

Our main focus is to understand how age and age-related disorders like diabetes, stroke and obesity influence brain structure, blood flow and functional connectivity, and how these changes in the brain lead to cognitive and functional impairments. Our goal is to design conduct clinical trials and implement new strategies to promote successful aging, facilitate independence of older people and prevent functional decline. The main components are: translational clinical research, neurophysiological and locomotor assessments, magnetic resonance imaging and mathematical modeling.

Vera Novak, MD, PhD

Associate Professor of Medicine, Director SAFE Program, Adjunct Professor of Mathematics North Carolina State University; Faculty- Center for Dynamical Biomarkers and Translational Medicine, National Central University, Taiwan

Dr. Novak's interests include mechanisms of cerebrovascular regulation, imaging and biotechnologies for prevention and treatment of age-related disorders.

Current Trials: Enrolling

Memory Advancement with Intranasal Insulin (MemAID)

Type 2 diabetes accelerates brain aging, alters brain blood flow and increases risk of dementia. Insulin plays a role in protecting neurons from its deleterious effects. Our previous study showed that intranasal insulin improved memory and learning in participants with type 2 diabetes and healthy controls, without affecting sugar levels in the blood. MemAID is an ongoing randomized control trial that evaluates potential benefits of 40 IU of Novolin® R or placebo (sterile saline) as a nasal spray using a Via Nase device (Kurve Technology,Inc) once daily for 24 weeks, with 24 weeks of the follow-up on cognitional, gait and functional outcomes. We plan to enroll 120 type 2 diabetics and 90 controls, more than 50 years old.

(Compensation up to $1000 for completing the study) (NIH NIDDK- 1R01DK103902-4, NCT04215556). Online pre-screening is available.

Additional Information

Watch a video about BIDMC’s diabetes research.
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The SAFE Program has established collaborations with top researchers around the world

World map showing all SAFE Program collaboration locations

The studies were supported by NIH 1R01DK103902-01Al, NIH-NIA 1R01-AG0287601A2, NIH-NIDDK SR21 DK084463, American Diabetes Association, Clinical 1-03-CR-23 and 1-06-CR-25; NIH-National Institutes on Diabetes and Kidney Diseases SR21- DK084463-02; 1R01DK103902-01Al; Novo Nordisk, Inc. Medtronics Inc. to Dr. Vera Novak. The projects described were also supported by Grant Number Ull RR025758- Harvard Clinical and Translational Science Center and M0l-RR-01032, from the National Center for Research.

Bibliography

Hyskova L, Dostalek C, Lepicovska (Novak) V: Strictly simultaneous classical eye-lid conditioning in man. Activ. Nerv. Super. (Prague) 1981; 23: 20-1.
Roldan E, Bohdanecky Z, Dostalek C, Lansky P, Indra M, Lepicovska (Novak) V, Radil T: Computer analysis of EEG during some Hathayogic exercises. Activ. Nerv. Super. (Prague) 1981; 23: 49-50.
Dostalek C, Lepicovska (Novak) V: Hatha yoga - a method for prevention of cardiovascular diseases. Activ. Nerv. Super. (Prague) 1982; 3 Suppl 1: 444-52.
Fabian Z, Lepicovska V (Novak), Dostalek C: On the analysis of quasiperiodical changes in EEG and respiration during breathing exercises. Activ. Nerv. Super. (Prague) 1982; 3: 173.
Stancak Jr A, Fabian Z, Lepicovska (Novak) V, Honig J, Wackermann J: Spectral analysis of cardiac reporalization phenomena. Wiss. Zeitschrift der Humbolt Univer. zu Berlin R. Med. 1990; 3:104-7.
Novak P, Lepicovska (Novak) V, Dostalek C: Periodic amplitude modulation of EEG. Neurosci. Lett. 1992; 136: 213-15.
Novak P, Lepicovska (Novak) V: Slow modulation of EEG. Neuroreport 1992; 3:189-92.
Novak P, Lepicovska (Novak) V: Increase of slow periodic modulation of EEG in a patient with Alzheimer's disease. Res. 1992; 41:293-7.
Lepicovska (Novak) V, Novak P, Drozen D: Positive pressure on neck decreases the baroreflex response to apnoea. Autonom. Res. 1992; 2: 21-7.
Lepicovska (Novak) V, Novak P, Nadeau R: Time-frequency mapping in neurally mediated syncope. Clin. Autonom. Res. 1992; 2: 317-26.
Novak V, Novak P, de Champlain J, Le Blanc AR, Nadeau R: Influence of respiration on heart rate and blood pressure fluctuations. J. Appl. Phys. 1993; 74: 617-26.
Novak P, Novak V: Time-frequency mapping of R-R intervals, blood pressure and respiratory signals. Med. Biol. Comp. Eng. 1993; 31:103-10.
Novak P, Li Z, Novak V, Hatala R: Time-frequency mapping of the entire QRS complex in normal subjects and in post myocardial infarction patients. J. Electrocardiol. 1994; 27: 49-60.
Novak P, Novak V, Remillard G, Li Z: Slow brain activity and blood pressure instability in a patient with Alzheimer's disease. Clin. Autonom. Res. 1994; 4: 141-8.
Novak V, Novak P, deChamplain J, Nadeau R: Altered breathing pattern in hypertensive patients. Hypertension 1994; 23:104-13.
Novak V, Novak P, Schondorf R: Accuracy of long duration noninvasive measurement of finger arterial pressure using Finapres: A spectral analysis approach. J. Clin. Monitoring 1994; 10: 118-26.
Novak V, Novak P, Nadeau R, Kus T: Slow cardiovascular rhythms at tilt and syncope. J. Clin. Neurophys. 1995; 12: 64-71.
Novak V, Novak P, de Marchie M, Schondorf R: Desynchronization of cardiovascular rhythms after severe brainstem injury. Clin. Autonom. Res. 1995; 5: 24-30.
Novak V, Honos G, Schondorf R: Is the heart “empty” at syncope? J. Auton. Nerv. System 1996; 60:83-92.
Novak V, Novak P, Opfer-Gehrking TL, Low PA: Postural tachycardia syndrome J. Auton. Nerv. Syst. 1996; 61:313-20.
Cupples WA, Novak P, Novak V, Salevsky F: Anesthetic specific alteration of renal blood flow dynamics in normotensive rats. Am. J. Physiol. 1996; 270 (Renal Fluid Electrolyte Physiol. 39) F82-F89.
Fujimura J, Camilleri M, Low PA, Novak V, Novak P, Opfer-Gehrking TL: Effect of perturbations and a meal on superior mesenteric artery flow in patients with orthostatic hypotension: Toward a test for abdominal sympathetic function. J. Auton. Nerv. Syst. 1997; 67: 15-23.
Bharucha AE, Novak V, Camilleri M, Zinsmeister A, Hanson RB, Low PA: a2 modulation of colonic tone during hyperventilation. J. Physiol. 1997; 273 (Gastrointest. Liver Physiol 36): G1135-G1140.
Novak V, Novak P, Spies, JM, Low PA: The autoregulation of cerebral blood flow in orthostatic hypotension. Stroke 1998; 29: 104-11.
Novak V, Novak P, Opfer-Gehrking TL, O’Brien P, Low PA: Predictors of orthostatic intolerance severity. Mayo Clinic Proc. 1998; 1141-1151.
Novak V, Novak P, Spies, JM, Opfer-Gehrking TL, Low PA: Hyperventilation contributes to cerebral hypoperfusion in orthostatic intolerance. Stroke 1998; 29: 1876-1881.
Novak V, Reeves AL, Novak P, Scarbrough F, Low PA: Time-frequency mapping of R-R interval during complex partial seizures of temporal lobe origin. J. Auton. Nerv. Syst. 1999; 77:195-202.
Low PA, Novak V, Novak P, Spies JM, Petty GW: Cerebrovascular vasoregulation in postural tachycardia syndrome (POTS). J. Med. Sci. 1999; 317:124-33.
Mosek A, Novak V, Low PA: Autonomic nervous system changes in migraineurs. Headache 1999; 39: 108-17.
Periquet I, Novak V, Sahenk Z, Freimer M, Nash S, Collins M, Nagaraja M, Mendell J: Painful sensory neuropathy: Prospective evaluation using skin biopsy. Neurology 1999; 53: 1641-47.
Sandroni P, Novak V, Opfer-Gehrking TL, Huck, CA and Low PA: Mechanisms of blood pressure alterations in response to the Valsalva maneuver postural tachycardia syndrome. Clin. Auton. Res. 2000; 10: 1-5.
Gordon VM, Opfer-Gehrking TL, Novak V, Low PA: Hemodynamic and symptomatic effects of acute interventions on tilt in patients with the postural tachycardia syndrome. Clin. Auton. Res. 2000; 10: 29-33.
Novak P, Novak V, Kangarlu A, Abduljalil A, Chakeres D, Robittaille P: High resolution MRI of the brainstem at 8 Tesla. J. Comp. Assist. Tomogr. 2001; 25: 242-46.
Novak V, Freimer M, Kissel, JT, Sahenk, Z, Periquet IM, Nash S, Periquet IM, Collins M, Mendell JR: Autonomic impairment in painful sensory neuropathy. Neurology 2001; 56: 861-68.
Novak V, Kangarlu A, Abduljalil A, Novak P, Slivka A, Chakeres D, Robittaille PM: Ultra high field MRI of subacute hemorrhagic stroke at 8 Tesla. J. Comp. Assist. Tomogr. 2001; 25: 431-35.
Novak V, Abduljalil A, Kangarlu A, Bourekas E, Slivka A, Novak P, Chakeres D: Intracranial ossification and microangiopathy at 8 Tesla MRI. Magn. Reson. Imaging 2001; 19: 1133-7
Novak V, Kanard, R, Kissel JT, Mendell JRM: Treatment of painful neuropathy with Tiagabine. Clin. Auton. Res. 2001, 11: 357-61.
Deschamps A, Backman SB, Novak V, Plourde G, Fiset P, Chartrand D: Effects of the anticholinesterase edrophonium on spectral analysis of heart rate and blood pressure variability in humans. J. Pharmacol. Exper. Ther. 2002; 300: 112-7.
Chakeres DW, Abduljalil AM, Novak P, Novak V: Case report: Comparison of 1.5 and 8Tesla high-resolution magnetic resonance imaging of lacunar infarcts J. Comp. Assist. Tomogr. 2002; 26: 628-32.
Novak V, Chowdhary A, Farrar B, Nagaraja H, Braun J, Kanard R, Novak P, Slivka A: Altered cerebral vasoregulation in hypertension and stroke. Neurology 2003; 60: 1657-63
Abduljalil AM, Schmalbrock P, Novak V, Chakeres DW: Enhanced gray and white matter contrast of phase susceptibility weighted images at ultra-high field MRI. J. Magn. Reson. Imaging 2003; 18:284-90.
Novak V, Chowdhary A, Abduljalil AM, Novak P, Chakeres D: Venous cavernoma at 8 Tesla MRI. Magn. Reson. Imaging 2003; 21:1087-9
Novak V, Yang ACC, Lepicovsky L, Goldberger AL, Lipsitz LA, Peng CK: Multimodal pressure-flow method to assess dynamics of cerebral autoregulation in stroke and hypertension. BioMedical Engineering OnLine 2004, 3:39 (Oct 25, 2004)
Novak V, Abduljalil A, Novak P, Robitaille PM: High resolution ultra high field MRI of stroke. Magn. Reson. Imaging 2005; 23:539-48.
Lagerlund TD, Low PA, Novak V, Novak P, Hines SM, McPhee B, Busacker NE: Spectral analysis of slow modulation of EEG amplitude and cardiovascular variables in subjects with postural tachycardia syndrome. Autonom. Neurosci. 2005; 117:132-42.
Hessert MJ, Vyas M, Leach J, Lipsitz L, Novak V: Foot pressure distribution in young and old. BMC Geriatrics. BMC Geriatrics 2005; 5:8.
Olufsen MS, Ottesen JT, Tran HT, Ellwein LM, Lipsitz LA, Novak V:. Blood pressure and blood flow variation during postural change from sitting to standing - mathematical modeling and experimental validation. J. Appl. Physiol. 2005, 99 1523-37.
Chen Z, Hu K, Stanley E, Novak V*, Ivanov P: Cross correlation of instantaneous phase increments in pressure-flow fluctuations: Applications to cerebral autoregulation. Physics Review E 73, 03195, 2006. *VN and PI contributed equally to this manuscript.
Novak P, Novak V: Effect of step-synchronized vibration stimulation of soles upon gait in Parkinson's disease: A pilot study. Journal of NeuroEngineering & Rehabilitation 2006 May 4; 3:9.
Novak V, Last D, Alsop DC, Abduljalil AM, Hu K, Lepicovsky L, Cavallerano J, Lipsitz LA: Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes mellitus. Diabetes Care 2006; 29:1529-1534.
Chen Z, Hu K, Stanley E, Novak V*, Ivanov P: Cross correlation of instantaneous phase increments in pressure-flow fluctuations: Applications to cerebral autoregulation. Virtual Journal of Biological Physics Research 2006 March 15;:11. *VN and PI contributed equally to this manuscript.
Olufsen MS, Tran HT, Ottesen JT, Research Experiences for Undergraduates Program, Lipsitz LA, Novak V: Modeling baroreflex regulation of heart rate during orthostatic stress. Am. J. Physiol. Regul Integr Com Physiol. 2006; 291:R1355-68. Rated as the most read article in Oct issue AJP 2006.
Novak V, Hu K, Vyas M, Lipsitz L: Cardio-locomotor coupling in young and old. J. Gerontology A Biol Sci Med Sci. 2007; 62:86-92.
Last D, Alsop DC, Abduljalil AM, Marquis RP, de Bazelaire C, Hu K, Cavallerano J, Novak V: Global and regional effects of type 2 diabetes mellitus on brain tissue volumes and vasoreactivity. Diabetes Care 2007; 30:1193-99.
Hajjar I, Selim M, Novak P, Novak V: The relationship between nighttime dipping in blood pressure and cerebral hemodynamics in nonstroke patients. J. Clin. Hypertens (Greenwich), 2007 12: 929-936.
Batzel JJ, Novak V, Kappel F, Olufsen MS, Tran HT: Introduction to the special issues: Short-term cardiovascular- respiratory control. Cardiovasc. Engineering 2008; 8:1-4.
Olufsen M, Alston AV. Tran HT, Ottesen JT, Novak V: Modeling heart rate regulation- part I. Sit-to-stand versus head-up tilt. Cardiovascular Engineering 2008; 2:73-87.
Ellwein LM, Tran HT, Zapata C, Novak V, Olufsen MS: Sensitivity analysis and model assessment: Mathematical models for arterial blood flow and pressure. Cardiovascular Engineering 2008; 8:94-108.
Hu K, Peng CK, Huang NE, Wu Z, Lipsitz LA, Cavallerano J, Novak V: Altered phase interactions between spontaneous blood pressure and flow fluctuations in type 2 diabetes mellitus: Nonlinear assessment of autoregulation. Physics A 2008; 387: 2279-2292.
Hu K, Peng CK, Czosnyka M, Zhao P, Novak V: Nonlinear assessment of cerebral autoregulation from spontaneous blood pressure and cerebral perfusion pressure fluctuations. Cardiovascular Engineering 2008; 8:60-71.
Lo MT, Hu K, Liu Y, Peng CK, Novak V: Multimodal Pressure Flow Analysis Enables Assessment of Cerebral Autoregulation Dynamics During Baseline Resting Conditions. EURASIP J Adv Signal Processing 2008; 2008:785243.
Devault K, Gremaud PA, Novak V, Olufsen MS, Vernieres G, Zhao P: Blood flow in the circle of Willis: Modeling and calibration. Multiscale Modeling & Simulation 2008; 7: 888-909.
Selim M, Jones R, Novak P, Zhao P, Novak V: The effects of body mass index on cerebral blood flow velocity. Clinical Autonomic Research 2008; 6: 331-8.
Zhao P, Alsop D, Abduljalil A, Selim M, Lipsitz L, Novak P, Caplan L, Hu K, Novak V: Vasoreactivity and periinfarct hyperintensities in stroke. Neurology 2009; 72:643-9.
u K, Lo MT, Peng CK, Novak V, Schmidt EA, Kumar A, Czosnyka M: Nonlinear pressure-flow relationship is able to detect asymmetry of brain blood circulation associated with midline shift. J. Neurotrauma 2009; 26:227-33.
Pope SR, Ellwein LM, Zapata CL, Novak V, Kelly CT, Olufsen MS: Estimation and identification of parameters in a lumped cerebrovascular model. Math Biosci Eng. 2009; 6: 93-115.
Novak V, Haertle M, Zhao P, Hu K, Munshi M, Novak P, Abduljalil A, Alsop D: White matter hyperintensities and dynamics of postural control. Magn Reson Imaging 2009; 6:752-9.
Lo MT, Novak V, Peng CK, Liu Y, Hu K: Nonlinear phase interaction between nonstationary signals: A comparison study of methods based on Hilbert-Huang and Fourier transforms. Phys Rev E Stat Nonlin Soft matter Phys. 2009;79:061924.
Hajjar I, Hart M, Milberg W, Novak V, Lipsitz L: The rationale and design of the antihypertensives and vascular, endothelial, and cognitive function (AVEC) trial in elderly hypertensives with early cognitive impairment: Role of the renin angiotensin system inhibition. BMC Geriatrics 2009, 9:48.
Lou M, Al-Hazzani A, Goddeau R, Novak V, Selim M: Relationship between white matter hyperintensities and hematoma volume and growth in patients with intracerebral hemorrhage. Stroke 2010;41:34-40.
Hajjar I, Zhao P, Alsop D, Abduljalil A, Selim M, Novak P, Novak V: Association of blood pressure elevation and nocturnal dipping with brain atrophy, perfusion and functional measures in stroke and non-stroke individuals. Am J Hypertens. 2010; 1:17-23.
Novak V, Hu K, Desrochers L, Novak P, Caplan L, Lipsitz L, Selim M: Cerebral flow velocities during daily activities depend on blood pressure in patients with chronic ischemic infarctions. Stroke 2010,41:61-66.
Aoi M, Gremaud P, Tran HT, Novak V, Olufsen MS: Modeling cerebral blood flow and regulation. Conf. Proc IEEE Eng Med Biol Soc. 2009, 2009:5470-3.
Manor B, Hu K, Zhao P, Selim M, Alsop DC, Novak P, Lipsitz LA, Novak V: Altered control of postural sway following cerebral infarction: a cross-sectional analysis. Neurology 2010;74: 458-464.

Editorial: Rundek T, Lali K: Visual input is critical for postural control in patients with chronic right hemispheric infarcts. Neurology 2010; 74:448-449.
Manor B, Costa M, Hu K, Newton E, Starobinets OV, Kang GH, Peng CK, Novak V, Lipsitz LA. Physiological complexity and system adaptability: Evidence from postural control dynamics of older adults, J Applied Physiol. 2010;7:686-98.
Hajjar I, Zhao P, Alsop D, Novak V: Hypertension and Cerebral Vasoreactivity: A Continuous Arterial Spin Labeling MRI study: Hypertension 2010; 56:859-64.
Rissanen S, Kankaanpaa M, Tarvainen M, Novak V, Novak P, Hu K, Manor B, Airaksinen O, Karjalainen P. Analysis of EMG and acceleration signals for quantifying the effects of deep brain stimulation in Parkinson’s disease. IEEE Trans.Biomed.Eng. 2011;58:2545-2553.
Novak V, Zhao P, Manor B, Sejdic E, Alsop D, Abduljalil A, Roberson PK, Munshi M, Novak P. Adhesion molecules, altered vasoreactivity and brain atrophy in type 2 diabetes. Diabetes Care 2011:11: 2438-41.
Manor B, Hu K, Peng CK, Lipsitz L, Novak V. Posturo-respiratory synchronization: Effects of aging and stroke. Gait and Posture 2012:36:254-9
Kashif FM, Verghese GC, Novak V, Czosnyka M, Heldt T: Noninvasive continuous estimation of intracranial pressure. Science Translational Medicine: 2012: 4:129-144.

Focus: Goldstein, B.; Tasker R.C.; Wakeland W.: From Lundberg to SIM-ICP: Computational Physiology and Modeling Intracranial Pressure. Science Translational Medicine: 2012: 4:129-144
Hu K, Lo MT, Peng CK, Liu Y, Novak V: A nonlinear dynamic approach reveals a long-term stroke effect on cerebral blood flow regulation at multiple time scales. PLos Comput. Biol. 2012; 8:e1002601.
Manor B, Newton E, Abduljalil A, Novak V: The relationship between brain volume and walking outcomes in older adults with and without diabetic peripheral neuropathy. Diabetes Care 2012, 35: 1907-1912 PMCID 3424988.
Hao Y, Manor B, Liu J, Zhang K,Chai Y, Lipsitz L, Peng CK, Novak V, Wang X, Zhang J, Fang J. Novel MRI-compatible tactile stimulator for cortical mapping of foot sole pressure stimuli with fMRI. Magn Reson Med. 2013 69: 1194-1199..
Drew DA, Bhadelia R, Tighiouart H, Novak V, Scott TM, Lou KV, Shaffi K, Weiner DE, Sarnak MJ: Anatomic brain disease in hemodialysis patients: A cross-sectional study. Am J of Kidney Dis. 2012 61:271-278.
Aoi M, Hu K, Lo MT, Selim M, Olufsen M, Novak V. Impaired cerebral autoregulation is associated with brain atrophy and worse functional status in chronic ischemic stroke. PLos One 2012; 7:e46994.
Wayne PM, Manor B, Novak V, Costa M, Hausdorff JM, Goldberger AL, Ahn AC, Yeh GY, Peng CK, Lough M, Davis RB, Davis RB, Quilty MT, Lipsitz LA. A systems biology approach studying Tai Chi, physiological complexity and healthy aging: Design and Rationale of a pragmatic randomized control trial. Contemp Clin Trials 201334: 21-34.
Hajjar I, Chui H, Hart M, Novak V, Lipsitz L. Antihypertensive therapy and cerebral hemodynamics in executive mild cognitive impairment: results of a pilot randomized clinical trial. J Am Geriatr Soc. 2013; 61:194-201.
Novak P, Williams A, Ravin P, Zurkiya O, Abduljalil A, Novak V. Treatment of multiple system atrophy using intravenous immunoglobulin. BMC Neurology 2012,12 : 131.
Hajjar I, Hart M, Hin S, Novak V, Lipsitz L. Safety and blood pressure trajectory of short-term withdrawing of antihypertensive medications in older adults with hypertension: experience from a clinical trial population. J. Am. Soc Hypertens 2013; 7 289-93.
Farzan F, Wu Y, Manor B, Anastasio EM, Lough M, Novak V, Greenstein PE, Pascual-Leone A.

Cerebellar TMS in treatment of a patient with cerebellar ataxia: Evidence from clinical, biomechanics and neurophysiological assessments. Accepted Cerebellum CERE-D-12-00114R1,4-8-2013.
Valkeinen H; Hajjar I;Hu K;Manor B;Wisocky J; Novak V. Effects of exercise program on physiological function in postmenopausal women with metabolic syndrome. Int. J. Gerontology, 2013, 7: 231-235.
Chen, I.H.; Novak ; Manor B.: Infarct hemisphere and non-infarcted brain volumes affect locomotor performance following stroke. Neurology 2014; 82:828-34..
Novak, V.; Milberg, W.; Hao,Y.; Munshi, M., Novak, P., Galica, A.; Manor, B.; Roberson, P.; Craft,S.; Abduljalil,A.: Enhancement of vasoreactivity and cognition by intranasal insulin in type 2 diabetes. Diabetes Care. 2014 37:751-9.
Cui, X.; Abduljalil, A.; Manor, B.; Peng, C.K.; Novak V. Multi-Scale glycemic variability; A link to gray matter atrophy and cognitive decline in type 2 diabetes. Plos One 20139: e8624.
Franke, K.; Gaser, C; Manor, B.; Novak V.: Advanced BrainAge in older adults with type 2 diabetes. Front. Aging Neurosci. 2013 5:90.
Meel-van den Abeelen AS, Simpson DM, Wang LJ, Slump CH, Zhang R, Tarumi T, Rickards CA, Payne S, Mitsis GD, Kostoglou K, Marmarelis V, Shin D, Tzeng YC, Ainslie PN, Gommer E, Müller M, Dorado AC, Smielewski P, Yelicich B, Puppo C, Liu X, Czosnyka M, Wang CY, Novak, V.; Panerai R.B., Claassen J : Between-centre variability in transfer function analysis, a widely used method for linear quantification of the dynamic pressure-flow relation: the CARNet study. Medical Engineering &Physics,2014 36 620-7..
Wayne PM, Manor B, Novak V, Costa MD, Hausdorff JM, Goldberger AL, Ahn AC, Yeh GY, Peng CK, Lough M, Davis RB, Quilty MT, Lipsitz LA.: A system biology approach to studying Tai Chi, physiological complexity and healthy aging design and rationale of a pragmatic randomized controlled trial. Contemp Clin Trials. 2013 34: 21-34.
Massei M, Tremori A, Novak V, Poggi S, Bartolucci C, Ferrando A, Chiurco A.. Obesity epidemic simulation based on behavioral models and intelligent agents. International Journal of Privacy and Health Information Management. 2013: 1, 96-114.
Jor’dan A, Manor B, Novak V.: Slow gait speed-an indicator of lower cerebral vasoreactivity in type 2 diabetes mellitus. Front. Aging Neurosci. 2014:6:135.
Mehta D, Pimentel DA, Nunez MZ, Abduljalil A, Novak V.:Subclinical albuminuria is linked to gray matter atrophy in type 2 diabetes. Metabolism 2014:11:1390-7.
Zhang H; Hao Y, Manor B, Novak P, Milberg W, Zhang J, Fang J, Novak V. Intranasal insulin enhanced resting state functional connectivity of hippocampal regions in type 2 diabetes. Diabetes 2015:64:1025-34. Editorial:Gottschalk A, Ellger B. Whenever you lose connection, take intranasal insulin ? Diabetes 2015:64:687-688.
Wayne PM, Gow BJ, Costa MD, Peng CK, Lipsitz LA, Hausdorff JM, Davis RB, Walsh JN, Lough M, Novak V, Yeh GY, Ahn AC, Macklin EA, Manor B.: Complexity-based measures inform effects of Tai Chi training on standing postural control. Cross-sectional and randomized trial studies. PLos One 2014;9 : e11473
Pimentel DA, Ravin P, Hays AP, Qin L, Novak V, Novak P. Markers of Parkinson’s disease progression using cerebrovascular, autonomic and small fiber neuropathy features. J. Neurol. Disorders 2015;3:2. . doi:10.4172/2329-6895.1000217
Wayne PM, Hausdorff JM, Lough M, GowBJ, Lipsitz LL, Novak V, Macklin EA, Peng CK, Manor B.: Tai Chi training may reduce dual task gait variability, a potential mediator of fall risk, in healthy older adults: cross-sectional and randomized trial studies. Frontiers in Aging Neuroscience 2015, 5.25.
Walsh JN, Manor B, Haudsorff J, Novak V, Lipsitz L, Gow B, Macklin EA, Peng CK, Wayne P. impact of short- and long term Tai Chi mind-body exercise training on cognitive function in healthy adults: Results from a hybrid observational study and randomized control trial. Global Advances in Health and Medicine (gahmj<J-15-058) IN press 5.29.2015).
Chung CC, Pimentel D, Jor’dan AJ, Hao Y, Milberg W, Novak V. Inflammation-associated declines in cerebral vasoreactivity and cognition in type 2 diabetes. Neurology 2015;85:1-9.
Novak P, Pimentel DA, Sundar B, Moonis M, Quin L, Novak V. Association of Statins with Ganglionopathy. Front Aging Neurosci. Oct 7; 7:191,2015
Dubey P, Lioutas VA, Bhadelia R, Manor B, Novak P, Selim M, Novak V.: Quantitative microstructural deficits in chronic phase of stroke with small volume infarcts: A Diffusion Tensor 3-D tractographic analysis. Magnetic Resonance Imaging 2016,11 (3) 400-1.
Alfaro FJ, Lioutas VA, Pimentel DA, Chung CC, Bedoya F, Yoo WK, Novak V.: Cognitive decline in metabolic syndrome is linked to microstructural white matter abnormalities. J. Neurol. 2016,263: 2505-2514.
Hart J, Novak V, Saunders C, Gremaud PA: Transcranial Doppler-based surrogates for cerebral blood flow. PLos One 2016, 11(11) e0165536.
Chi NF, Ku HL, Wang CY, Liu Y, Chan L, Lin YC, Peng CK, Novak V, Hu HH, Hu KC: Dynamic cerebral autoregulation assessment using extracranial internal carotid artery Doppler Ultrasonography. Ultrasound in Medicine and Biology UMB-D-16-00543R2, In Press ( 2.2.2017)
Jor’dan AJ; Manor, B; Hausdorff JM, Lipsitz L, Habtemariam D, Novak V, Wayne P.: Long-term Tai Chi Training is associated with better dual-task postural control and cognition in older adults. Journal of Aging and Physical Activity JAPA-2017-0140 In Press (5.9.2017).
Gow BJ, Hausdorff J, Manor B, Lipsitz L, Novak V, Bonato P, Mackin E, Peng, CK, Ahn A, Wayne P: Can Tai Chi impact fractal stride dynamics, an index of gait health, in older adults? Plos One https://doi.org/10.1371/journal.pone.0186212 Oct 11, 2017.
Dai W, Duan W, Alfaro FJ, Gavrieli A, Kourtelides F, Novak V: The resting perfusion pattern associates with functional decline in type 2 diabetes. Neurobiology of Aging (doi:10.106/j.neurobioloaging.2017.09.004).
Chi NF, Ku HL, Wan CY, Liu Y, Chan L, Lin YC, Peng CK, Novak V, Hu HH, Hu CJ. Dynamic cerebral autoregulation assessment using extracranial internal carotid artery Doppler. Ultrasound Med Biol. 2017,43:1307-1313.
Jor’dan AJ, Manor B, Hausdorff JM, Lipsitz L, Habtemariam D, Novak V, Wayne P: Long-term Tai Chi training is associated with better dual-task postural control and cognition in aging adults. Advances in Mind Body Medicine 1182 (Accepted July 10, 2018).
Chen Y, Duan W, Sehrawat P, Chauhan V, Alfaro FJ, Gavrieli A, Novak V, Dai W: Improved perfusion pattern score association with type 2 diabetes severity using machine learning pipeline. Journal Magnetic Resonance Imaging (JMRI-18-0418.R1). Accepted June 26, 2018.
Chung CC, Pimentel DA, Jor’dan AJ, Alfaro FJ, Lioutas VA, Nunez MZ, Novak V: Lower cerebral vasoreactivity as a predictor of gait speed decline in type 2 diabetes mellitus. J. Neurol. JOON-D-18-00538R1 (Accepted July19, 2018).
Ma Y, Wu CW, Peng CK, Ahn A, Bertish S, Lipsitz L, Yeh GY, Mano B, Novak V, Hausdorff JM, Gow B, Wayne P. Complexity-based measures of heart rate dynamics in older adults following long- and short-term Tai Chi training: Cross-sectional and randomized Trial Studies ( ASREP-18-08252A) Scientific Reports (Accepted August 20, 2018
Chi NF, Hu HH, Wang CY, Chan L, Peng CK, Novak V, HU CJ. Dynamic cerebral autoregulation is an independent functional outcome predictor of mild acute ischemic stroke. Stroke 2018/022481R1 (Accepted Sep.11.2018)

Other Peer-Reviewed Publications

Novak V, Novak P, Low PA: Interpretation of oscillations in heart rate and blood pressure. In: Di Rienzo M, Mancia G, Parati G, Pedotti A, Zanchetti A, editors. Frontiers of blood pressure and heart rate analysis. Amsterdam: IOS Press; 1997 vol. 35, p. 129-42.
Novak V, Novak P, Reeves A, Low PA: Autonomic correlates of orthostatic intolerance and seizures. In: Di Rienzo M, Mancia G, Parati G, Pedotti A, Zanchetti A, editors. Methodology and clinical applications of blood pressure and heart rate analysis. Studies in health and technology; vol. 60. Amsterdam: IOS Press; 1999, p. 189-206.
Aoi M, Kelly CT, Novak V, Olufsen MS. Optimization of a mathematical model of cerebral autoregulation using patient data. Proceedings of the 7th IFAC Symposium on Modelling and Control in Biomedical Systems, Aalborg, Denmark, August 12-14,2009.

Reviews, Chapters, Monographs and Editorials

Dostalek C, Votava J, Lepicovska (Novak) V, Dostalova V, editors: The use of yoga in medicine. (In Czech) Prague: Avicenum; 1988.
Novak V, Novak P, Low PA: Time-frequency analysis of EEG and cardiovascular functions and their clinical applications. In: Low PA, editor. Clinical autonomic disorders. Philadelphia: Lippincott-Raven; 1997, p. 323-48.
Novak V, Saul JP, Eckberg D: Task force report on heart rate variability. Letter to the Editor. Circulation 1997; 96: 1056.
Novak P, Novak V, Petty G, Low PA: Transcranial doppler evaluation in disorders of reduced orthostatic tolerance. In: Low PA, editor. Clinical autonomic disorders. Philadelphia: Lippincott-Raven; 1997, p. 349-68.
Low PA, Novak V, Novak P, Sandroni P, Schondorf R, Opfer-Gehrking TL: Postural tachycardia syndrome. In: Low PA, editor. Clinical autonomic disorders. Philadelphia: Lippincott-Raven; 1997, p. 681-97.
Novak V, Mendell JRM: Evaluation of the peripheral neuropathy patient using autonomic reflex tests. In: Mendell JRM, Kissel JT, Cornblath DR, editors. Diagnosis and management of peripheral nerve disorders. Contemporary Neurology Series 59. Oxford: University Press; 2001, p.43-65.
Novak V: Orthostatic hypotension and orthostatic intolerance. In: Lynn DJ, Rae-Gray A, Newton H, editors. The 5-minute neurology consult. Philadelphia: Lippincott, Williams and Wilkins; 2004, p.326-7.
Novak V: Autonomic Testing. In: Lynn DJ, Rae-Gray A, Newton H, editors. The 5-minute neurology consult. Philadelphia: Lippincott, Williams and Wilkins; 2004, p.40.
Novak V, Lipsitz L: Aging and autonomic nervous system. In: Robertson D, Biaggioni I, Burnstock G, Low PA, editors. Primer on the autonomic nervous system, 2nd ed. Boston: Elsevier Academic Press; 2004, p. 191-193.
Novak V, Christoforidis G: Clinical promise: Clinical Imaging at Ultrahigh Field. In: Robitaille PM, Berliner LJ, editors. Ultra high field magnetic resonance imaging (UHFMRI): Theory and applications, biological magnetic resonance. A series of contemporary topics and reviews. New York: Springer; Oct. 2006, vol.26, Chapter 13.pp 411- 437.
Novak V, Novak P. Diabetic neuropathy. In: Munshi M, Lipsitz L, editors. Geriatric Diabetes Informa Healthcare, New York. 2007,Chapter 16: p. 207-221.
Lipsitz L, Novak V: Aging and the autonomic nervous system. In: Bannister R, Mathias C, editors. 2 Autonomic Failure. Oxford University Press,Chapter 66;798-810 2013
NICE guidelines Group and STARS Group: Transient loss of consciousness (TLoC) (“blackouts” management in adults and young people. National Institute for health and Clinical Excellence. The National Clinical Guideline Centre, issued August 2010 (http://www.nice.org.uk).
Lipsitz, Novak V: Aging and autonomic nervous system. In: Robertson D, Biaggioni I, Burnstock G, Low PA,Paton JF.R. editors. Primer on the Autonomic Nervous System, 3rd ed. Oxford ; Academic press, 2012, Chapter 51 pp.269-274.
Novak V, Hajjar I: The relationship between blood pressure and cognitive function. Nature Reviews Cardiology; 2010: 12:686-98.
Novak V: Cognition and hemodynamics. Curr Cardiovasc Risk Rep. 2012;6:380-396..
Novak V: Intranasal insulin: Is there a promise for treatment of diabetes-related cognitive decline ? Diabetes Management 2014:4:315-317.
Lioutas VA, Alfaro-Martinez F, Bedoya F, Chung CC, Pimentel D, Novak V: Intranasal insulin and insulin-like growth factor 1 as neuroprotectants in acute ischemic stroke. Transl Stroke Res 2015. June 5 ( PMID:26040423).(EPub)
Gomez A, Fregni F, Novak V: Basic Study Design. In: Fregni F, Illigens B editors: Critical Thinking in Clinical Research: Applied Theory and Practice Using Case Studies. Oxford University Press 2017 Chapter 4: :
Norcliffe-Kaufman L, Galindo-Mendez B, Garcia-Guarniz A.L., Villarreal-Vitorica, E. Transcranial Doppler in Autonomic testing: Standards and Clinical Applications. Clinical Autonomic Research (in Press 6.6.2017)
Alfaro F.J., Gavrieli A, Saade-Lemus P, Lioutas V.A., Upadhay J., Novak V. White matter microstructure and cognitive decline in metabolic syndrome: A review of diffusion tensor imaging Metabolism Clinical and Experimental 2018:78:52-68.
Novak V, Gomez F, Campos Diaz, Pimentel DA, Alfaro FJ. Diabetes-related cognitive decline a global health issues, and new treatment approaches. Int. J. Privacy and Health Informational Management 2017 (5)