Exercise and Your Heart
Posted 1/22/2013
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First, a quick vacation update. I don't plan to do this every day, but I have been feeling a little guilty with my postings about sunshine and Mexican food while most people I know are bundling up and wearing boots. So, just to remind us all that nothing is perfect: six people in our group are sick today, struck down overnight. We assume that it was something about dinner as a viral thing would not hit everyone at once. Those of us who are feeling okay are trying to figure out what they ate and we didn't--or whether it is just the differences between us. One suggestion is that the tequila might have killed off the bugs...
Writing today about the possibility (per this article) that exercise may be helpful with cardiac damage from herceptin and/or certain chemotherapy drugs. I have written many times before about the potential value of exercise, but this is a new and important twist. Here is the abstract and then a link:
The Potential Role of Aerobic Exercise to Modulate Cardiotoxicity of Molecularly Targeted Cancer Therapeutics
JESSICA M. SCOTT,a SUSAN LAKOSKI,b JOHN R.MACKEY,c PAMELA S. DOUGLAS,dMARK J. HAYKOWSKY,c LEE W. JONESd
ABSTRACT
Molecularly targeted therapeutics (MTT) are the future of
cancer systemic therapy. They have already moved from palliative
therapy for advanced solid malignancies into the setting
of curative-intent treatment for early-stage disease. Cardiotoxicity
isafrequentandpotentially serious adverse complication
of some targeted therapies, leading to a broad range of
potentially life-threatening complications, therapy discontinuation,
and poor quality of life. Low-cost pleiotropic interventions
are therefore urgently required to effectively prevent
and/or treat MTT-induced cardiotoxicity. Aerobic exercise
therapy has the unique capacity to modulate, without toxicity,
multiple gene expression pathways in several organ systems,
including a plethora of cardiac-specific molecular and cell-signalingpathwaysimplicated
inMTT-inducedcardiac toxicity. In this review, we examine the molecular signaling of antiangiogenic
and HER2-directed therapies that may underpin cardiac
toxicity and the hypothesized molecular mechanisms underlying
the cardioprotective properties of aerobic exercise. It is
hoped that this knowledge can be used to maximize the benefits
of small molecule inhibitors, while minimizing cardiac
damage in patients
http://theoncologist.alphamedpress.org/content/early/2012/12/13/theoncologist.2012-0226.short?rss=1
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