Cholesterol and Tamoxifen
Rebecca Riggins, PhD and collegues from the Georgetown University Lombari Cancer Center presented a most interesting preliminary study at last week's AACR (American Association for Cancer Research) meetings in Denver. They have found some evidence that : Breast cancer cells in the laboratory that don't respond to tamoxifen may be producing high amounts of cholesterol in order to provide a kind of shield against the drug.
They go to suggest that statin drugs, commonly used to lower cholesterol, might be helpful in the treatment of hormone positive breast cancers that are tamoxifen-resistant.
More information may be viewed at: http://www.sciencedaily.com/releases/2009/04/090420151221.htm
It is exciting that so much more is being learned about how to discriminate among cancers and to better determine the best treatment for any one individual.
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