Dr. Vikas P. Sukhatme
Our research efforts are both pre-clinical and translational. Our interest is in understanding the molecular, cellular, and network mechanisms that govern small and large vessel formation during development and relating these findings to human diseases characterized by abnormal vessel formation or function or an altered systemic angiogenic state. New efforts to set up lower vertebrate nephrotic and cystic kidney disease models and to use genomic and proteomic methods to understand the basis of minimal change disease and FSGS (collaboration with S. Karumanchi) are underway. The clinical studies are in the areas of dialysis vascular access dysfunction, in anti-angiogenic therapy and angiogenesis monitoring for cancer, and in pre-eclampsia.