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Mass Spectrometry (Proteomics / Metabolomics) Core

Core Summary

The mass spectrometry, metabolomics and proteomics core at Beth Israel Deaconess Medical Center was established in 2004 led by Dr. John Asara and continues to grow rapidly. We provide excellent proteomics and metabolomics services with low prices and fast turnaround times. We have cutting edge equipment operated at optimal sensitivity and work and publish with world class researchers. We also maintain an active internal cancer proteomics and metabolomics research program with collaborative efforts. Our expertise is in identifying and quantifying protein modifications and dynamic protein-protein interactions in addition to polar metabolomics profiling including metabolic flux analyses. Several different types of mass spectrometers are available for services depending upon your needs including stand-alone linear ion trap for protein identification, hybrid ion trap-high resolution orbitrap for protein quantification and post-translational modification (PTM) mapping, and triple quadrupole mass spectrometers for targeted quantification of metabolites and peptides. We accept samples from anywhere in the world and look forward to helping you and progressing your research to the next level.

NEWS:

  • We just received funding for a Thermo Velos Elite Orbitrap Mass Spectrometer!
    •  The Elite represents the ultimate proteomics instrument for speed, sensitivity, resolution and throughput
  • We just lowered our prices for large orders with more than 10 samples (proteomics only)
  • Metabolomics analyses are available for high-throughput profiling of both clinical and research samples

Recently, the core received much press attention for a Science article describing the use LC/MS/MS to sequence collagen protein fragments from a 68 million year old T. rex fossil.

We look forward to helping you progress your research with the most sensitive mass spectrometry technology that is currently available.

Personnel /Contact Information

John M Asara, Ph.D.
Director
Phone: 617-735-2651
Fax: 617-735-2655
Email: jasara@bidmc.harvard.edu

Other Staff:

Susanne Breitkopf, Ph.D.
Sr. Research Associate 

Min Yuan, M.S.
Research Associate

Proteomics & Metabolomics Services

  • Protein Complex Identification
    • (protein complexes, protein-protein interactions, single protein ID)
  • Identification of Post-Translational Modifications
    • (phosphorylation, acetylation, ubiquitination, etc.)
  • Relative Protein Quantification
    • (Label-free quantification, SILAC, Avg. TIC, iTRAQ, TMT)
  • Protein complex stoichiometry
  • Quantification of phosphorylation sites
  • Protein-Protein Interaction (PPI) networks
  • Quantitative Metabolomics Profiling
    • (endogenous polar metabolites from any cell, tissue, fluid source)
  • Steady-state profiling
  • 13C/15N metabolic flux analysis


Special projects may be possible, please contact us to discuss your project needs.

Getting Started 

More information regarding pricing, sample preparation and publications can be found at www.bidmcmassspec.org

Contact Information

Center for Life Science, Room 425
3 Blackfan Circle
Boston, MA 02115
617-735-2651
617-735-2655
jasara@bidmc.harvard.edu