http://bidmc.org/Research.aspx http://bidmc.org/Research/MissionStatement.aspx The mission of Beth Israel Deaconess Medical Center is to be a world-class research institution where outstanding scientists work to develop new knowledge for the betterment of the health of our local and extended communities. The research program strives to be renowned for its bench-to-bedside model of translational research, and for its collaboration with industry as a pathway for transferring the fruits of research into products that improve the quality of life. We commit to maintain a collaborative culture and modern, high-quality facilities, and to take full advantage of the unique relationships that exist among the Harvard Medical School and the Harvard teaching hospitals. Thu, 28 May 2009 20:47:23 GMT http://bidmc.org/Research/ResearchandAcademicAffairs.aspx Research and Academic Affairs (R&AA) is responsible for research & educational oversight. This includes research operations, government & corporate relations, intellectual property development, and graduate medical education. R&AA provide leadership in research strategic planning, collaboration between BIDMC, Harvard Medical School and other Harvard affiliated institutions. Mon, 16 Feb 2009 15:09:54 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/AcademicComputing.aspx Academic and Research Computing (ARC) provides advocacy and education regarding IT resources and infrastructure in support of the academic and research mission of BIDMC. ARC represents and interacts with Harvard faculty and staff at BIDMC, Research & Academic Affairs and Information Services. Mon, 16 Feb 2009 14:19:08 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/AnimalResearchFacility.aspx The primary function of ARF is to assist investigators in their obligation to plan and conduct animal experiments in accord with the highest scientific, humane and ethical principles. This is achieved by development and maintenance of a comprehensive, high quality animal care program, which is AAALAC accredited and complies with all Federal, State and Local laws. Fri, 13 Feb 2009 13:38:44 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/ClinicalTrialsOffice.aspx The CTO provides a central and comprehensive program of financial, legal, and administrative support to the research community at BIDMC, in keeping with institution’s mission of health care, education and the advancement of knowledge. Since its inception in 2003, the CTO has become a nationally recognized clinical trials center, known for its excellence in clinical research management by industry sponsors, the National Institutes of Health and other national and international academic medical centers. Fri, 13 Feb 2009 15:30:23 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/ClinicalTrialsOffice/FAQs.aspx As you consider treatment options for yourself or a loved one, you may be considering participation in a clinical trial. What is a clinical trial? Why do people participate in these studies? The information and links below will provide you with more information about clinical trials: what they are, how they work, and other resources that may be available to you. Fri, 13 Feb 2009 15:21:20 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/ClinicalTrialsOffice/SponsorResources.aspx The Clinical Trails Office (CTO) at BIDMC is dedicated to facilitating the relationship between sponsors and our investigators conducting clinical trials by providing a menu of centralized services including the preparation, negotiation and execution of budgets and contracts. We recognize the importance of bringing medical innovation to patients expeditiously and therefore strive to meet short deadlines and quick turnaround times, while maintaining ethical and quality standards expected of a Harvard affiliated Medical Center. Thu, 03 Sep 2009 18:44:32 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/CommitteeonClinicalInvestigation.aspx The Committee on Clinical Investigations, also known as the CCI, welcomes you to its website. Please use the menu on the left side of the screen to find out more information about the Committee, the CCI staff and Policies and Procedures. In addition, CCI application forms and instructions for submission of IRB protocols are available for download. Forms are subject to change, so please do not save form templates to your own desktop. Only current forms may be used for submission. Thu, 26 Feb 2009 17:53:38 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/CommitteeonClinicalInvestigation/ScientificReviewProcess.aspx The purpose of the scientific review process is to support the human research review process, including IRB review, by ensuring that human research conducted at BIDMC meets the highest level of scientific merit and design. To accomplish this goal, scientific reviewers representing the many clinical disciplines and the diverse human subject research portfolio at BIDMC are appointed to perform a scientific review of human research studies. Fri, 13 Feb 2009 16:02:19 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/CommitteeonClinicalInvestigation/ContactUs.aspx Contact Information for the Committee on Clinical Investigation Fri, 13 Feb 2009 16:05:47 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/CRC.aspx The Harvard - Thorndike Clinical Research Center is funded by the NIH National Center for Research Resources to provide clinical scientists the resources necessary to conduct patient-oriented research. The primary purpose of the CRC is to provide the clinical research infrastructure to investigators who receive their primary research funding from other components of the NIH. Wed, 11 Mar 2009 18:33:58 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/CRC/CRCResources.aspx testing, dental studies, transcranial magnetic stimulation studies, and studies of syncope and falls-in-the-elderly. The unit staff includes nurses, dieticians, a laboratory assistant, and a unit coordinator. The unit is open for patient activity 24 hours per day, 7 days per week. In addition, CRC staff are available to support research activity in other locations in the medical center. Core Laboratory facilities are available through the Harvard Catalyst for analysis of samples for various assays. In addition to the activities of the patient unit, the BIDMC CRC has an active Bionutrition core with expertise in body composition measurement, bioelectrical impedance, and metabolic testing. Located on the outpatient unit is a metabolic kitchen for preparation of nutrient controlled meals. The bionutrition unit also provides state of the art nutrition computing facilities with programs for nutrient analysis, semi-quantitative food frequency analysis, and design and specification of research diets. Fri, 13 Feb 2009 17:04:28 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/CRC/CRCResources/Administration.aspx The CRC administrative office is the first point of contact for investigators seeking CRC support for their clinical research protocols. The CRC Administrative office: Coordinates the scientific review of new protocols through the CRC’s Scientific Advisory Committee Serves a resource to investigators and staff in budgetary matters and clarification and interpretation of the CRC guidelines ..... Fri, 13 Feb 2009 17:11:32 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/CRC/CRCResources/Biostatistics.aspx The Biostatistics Core’s mission is to support the research activities of the BIDMC CTSC by reviewing all protocols,Assisting investigators with the design of their studies,advising investigators regarding data collection,statistical analysis.interpretation and so on Fri, 13 Feb 2009 17:18:12 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/CRC/CRCResources/Leadership.aspx This page has few lines about the Principal Investigator,Program Director,Sceintific Advisory Committee of the General Clinical Research Center at Beth Israel Deaconnes Medical Center Mon, 16 Feb 2009 14:26:15 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/CRC/CRCResources/Nursing.aspx The Nursing Service of the Beth Israel Deaconess Medical Center Clinical Research Center, is composed of an all RN staff. The nursing staff of the Clinical Research Center are dedicated to excellence in care, facilitating the clinical research program and supporting nursing research. Practicing in the collaborative practice model, used throughout nursing at BIDMC, each CRC nurse takes responsibility and accountability for providing care for study participants. Fri, 13 Feb 2009 17:42:44 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/CRC/CRCResources/Nutrition.aspx The resources like protocol development, research meal preparation,metabolic assesment,intake analysis,nutrition counselling and education are available to CRC Investigators at Beth Israel Deaconnes Medical center Thu, 07 May 2009 18:58:53 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/CRC/CRCResources/WebResources.aspx All types of web resources such as BIDMC,NIH,Government agencies,Foundations and so on are listed here. Fri, 13 Feb 2009 17:52:30 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/CRC/HolidaySchedule.aspx Scheules and list of holidays for the Harvard-Thorndike Clinical Research Center at BethISrael Deaconnes Medical Center. Fri, 13 Feb 2009 17:08:31 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/HumanSubjectProtection.aspx The purpose of the Human Subjects Protection Office (HSPO) at Beth Israel Deaconess Medical Center is threefold: Provide comprehensive protection to subjects who volunteer in human subjects research activities at this Institution Provide an educational and training program designed to educate the community, investigators, staff and patients in the safe and ethical conduct of research Assist researchers by monitoring current research activities to ensure the ethical conduct of human subjects research Mon, 16 Feb 2009 14:52:56 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/InstitutionalAnimalCareandUseCommittee.aspx The Beth Israel Deaconess Medical Center Institutional Animal Care and Use Committee (IACUC) reviews all animal use protocols, ensures compliance with federal regulations, inspects animal facilities and laboratories and oversees training and educational programs. The IACUC serves as a resource to faculty, investigators, technicians, students, staff, and administrators and provides guidance for conducting all animal use procedures with the highest scientific, humane, and ethical principles. The IACUC is composed of a chair, a veterinarian, research scientists, non-scientists, and community representatives. The IACUC makes semiannual inspections of all facilities and laboratories where animals are housed or utilized. Mon, 16 Feb 2009 15:18:26 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/OfficeofSponsoredPrograms.aspx The Office of Sponsored Programs (OSP) provides research administrative support to investigators at BIDMC who are applying for or who have been awarded contracts and grants various federal, commercial, non-profit or state agencies. The office is responsible for oversight of compliance actives associated with sponsored research and support services. Mon, 16 Feb 2009 16:17:40 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/ResearchFacilitiesOffice.aspx Research Facilities provides space and facilities management support to the Researchers and Research Administrators supporting the research mission at BIDMC. This newly reorganized group includes personnel to help with lab moves, research equipment inventory, space management and reporting, research facilities infrastructure support and strategic planning. Thu, 17 Sep 2009 14:21:16 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/ResearchPharmacy.aspx Evaluate protocols for ethical and scientific merit, as well as feasibility from an operational standpoint and cost potential to the medical center. Review protocol for adherence to federal regulations for investigational drugs. Mon, 16 Feb 2009 16:40:30 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice.aspx TVO is comprised of a group of technically trained and business-oriented professionals. We work with biomedical companies, venture capitalists, and entrepreneurs to find the best way to commercialize new technologies, and to promote corporate collaborations that can increase our level of industrial support for research Tue, 06 Oct 2009 15:47:47 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice/AboutUs.aspx The mission of the Technology Ventures Office (TVO) is to promote public utilization of Beth Israel Deaconess Medical Center (BIDMC) technologies for society’s use and benefit and to foster alliances with industry through collaboration and licensing agreements, while generating unrestricted income to support research at our institution. Fri, 13 Feb 2009 18:10:13 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice/MeetOurTeam.aspx Staff Biographies for the Technology Ventures Office at BIDMC. Thu, 26 Mar 2009 17:42:48 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice/ForInvestigators.aspx The Director and staff of the Technology Ventures Office (TVO) are available to consult with faculty and staff on any topic related to intellectual property, technology development and industry relations. Please feel free to call, e-mail or stop by the Technology Ventures Office with your questions and ideas, or for general information. Fri, 13 Feb 2009 18:30:34 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice/ForInvestigators/Services.aspx Material Transfer Agreements "Borrowing" or "Lending" materials from/to another academic institution or company requires a material transfer agreement (MTA) to protect intellectual property and publishing rights. Read this to learn more about MTAs. Invention Disclosure Form Do you have an idea you think might be patentable or of commercial value? Please complete this form and send to the TVO before you publish anything about your idea. Read this to learn more about patents and intellectual property. Invention Disclosure (MS Word form) Confidentiality Agreement Protecting your ideas with a Confidentiality Agreement during the period a company is evaluating them is essential. It is important to set-up a confidentiality agreement prior to the company meeting or company evaluation of your proprietary ideas. Please contact the TVO for additional information. Licensing Agreements Once a patent is filed the TVO markets the invention and negotiates a license agreement. The TVO also negotiates license agreements for non-patented research tools, such as reagents, software, and know-how. Fri, 13 Feb 2009 18:14:36 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice/ForInvestigators/InventionDisclosure.aspx One of the missions of Beth Israel Deaconess Medical Center (BIDMC) is to facilitate the transfer of the results of BIDMC research to the benefit of society in partnership with other organizations, both for-profit and non-profit. One objective of the Technology Ventures Office (TVO) is to encourage researchers to describe novel ideas, inventions, or biological materials that may have medical, research, and/or commercial uses. The purpose of this Invention and Technology Disclosure is to record an invention and related circumstances and to serve as the basis for an evaluation by the TVO of its patentability and potential for commercial application. This is an important, legal document and should be prepared carefully. In the context of this disclosure form, an invention may be any process or material that is new and useful and may result when research yields unusual or unexpected results. To be patentable, an invention should not be obvious to others in the field, not be used by others previously, and not be described in a publication or presentation (in the U.S., one is allowed to file a patent application within one year after a public disclosure). Print or download the form and please complete the form using the instructions below. Once the invention disclosure form is completed, please mail it to your case manager. As soon afterwards, please deliver a signed invention disclosure directly to: Technology Ventures Office, 330 Brookline Avenue, BR-2, Boston, MA 02215. For more information on how the TVO manages inventions as well as how any proceeds from their commercialization are distributed, please review the BIDMC Policy on Inventions and Intellectual Property. Instructions: The following instructions relate to the corresponding sections on the invention disclosure form. 1. Title : Please provide a brief title that is descriptive of the invention and its potential application. 2. Identification of Contributor(s): Include the names, addresses, and affiliations of all contributors. An inventor is an individual who has conceived an essential part of the invention either independently or jointly, but not necessarily one who participated in the research related to the invention. Inventorship will be determined by a Patent attorney. Please note in the section Other(s) if any named individual has an appointment at an institution other than BIDMC. 3. Financial Support/Contract Identification : Please give the name of the organization and grant numbers that provided any funding for yourself, others, and the research that lead to the invention (at other institutions, if applicable). 4. Origin of Biological, Chemical or Physical Material : Please indicate if a material transfer agreement or other document accompanied the transfer of any material involved to create this invention. Please name the material and institution/company involved in this transfer of material. 5. Description : Please describe what the invention is and what it does, e.g., its general purpose, technical details, advantages or improvements over existing methods or materials, patents or publications by others that may be similar. You may attach or insert an abstract from a manuscript, presentation, publication, or grant application and/or attach supporting materials (for example, drawings, tables, and figures). Included in this section are: (a) present a brief summary; (b) present stage of development and the next step(s) in the development of a commercial application of the invention; (c) commercial applications; (d) what is available in the field; and (e) a description of the advantages and improvements of your invention over the existing technology. 6. List Published Material : Please list patents, commercial literature and scientific articles relating to the invention. 7. Public Disclosure/Publication Plans : Has the invention been described (disclosed) outside BIDMC (e.g., abstracts, presentations in a poster session, publication, thesis, or grant application, disclosure to others outside of BIDMC who have not signed a confidentiality agreement, and/or use, sale or offer of sale of the invention) or was any material associated with it transferred to others outside BIDMC? 8. Potential Licensees : Please provide as much detail as possible of commercial entities that may be interested in licensing this invention. Please list commercial entities, if any, that you specifically do not want contacted regarding this technology and please indicate why. 9. Witness Statement : Please arrange for a witness to sign who has read and understood the disclosure; the witness may be a member of the TVO staff. The information on this webpage was originally provided with permission from the Intellectual Property Office Website of Children’s Hospital of Boston. This information has been modified by BIDMC TVO. Tue, 01 Sep 2009 21:51:23 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice/ForInvestigators/MaterialTransferAgreements.aspx MTAs are contracts that govern the exchange of research reagents, such as biomaterials or drugs, between BIDMC and academic institutions or companies. MTAs often form the basis for future collaborations. The TVO executes ~300 MTAs per year. Tue, 01 Sep 2009 21:47:00 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice/ForInvestigators/PatentPrimer.aspx A patent for an invention is the grant of a property right to the inventor, issued by the United States Patent and Trademark Office. Generally, the term of a new patent is 20 years from the date on which the application for the patent was filed in the United States. U.S. Patent grants are effective only within the United States, U.S. territories and U.S. possessions. Tue, 01 Sep 2009 21:47:00 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice/ForInvestigators/Policies.aspx Harvard's conflict of interest policy,BIDMC Conflict of interest policy,Caregroup Conflict of interest policy,BIDMC Resrearch Policy Fri, 15 May 2009 14:07:10 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice/ForIndustry.aspx The Technology Ventures Office (TVO) at Beth Israel Deaconess Medical Center (BIDMC) speeds the development of our researchers' groundbreaking discoveries by fostering strategic collaborations with industry partners through sponsored research and licensing agreements. Thu, 09 Apr 2009 20:54:48 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice/AvailableTechnologies.aspx The TVO database contains a selected list of available technologies from Beth Israel Deaconess Medical Center. The database is periodically updated with new technologies for bioinformatics, diagnostics and biomarkers, drug delivery and drug discovery tools, medical devices, medical imaging, research reagents, and therapeutics. Tue, 06 Oct 2009 14:54:25 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice/MarketedProducts.aspx The Technology Ventures Office at Beth Israel Deaconess Medical Center accelerates the development of our researchers’ innovative and ground breaking discoveries by fostering strategic collaborations with industry partners through sponsored research and licensing agreements. It is our focus to establish these types of relationships with industry to further develop and bring BIDMC technologies to market Thu, 09 Apr 2009 17:35:10 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice/PortfolioCompanies.aspx Beth Israel Deaconess Medical Center technology is available for starting up a business. In the Technology Ventures Office at BIDMC, innovation is the cornerstone of our alliance strategy. Our business practice flows from the entrepreneurial spirit at BIDMC. The Technology Ventures Office staff is interested in leveraging our research excellence through novel strategic alliances with venture capitalists, entrepreneurs and our research investigators to form new companies. This is a partial listing of companies in which BIDMC technology was involved during company formation. In most cases, BIDMC retains equity in the company. Ardais Aquila Pharma Cavatr Centagenetix* Contego Consensus Pharma Convergence Pharma deCode Microheart NMT* Pintex Pharma* Polystem* Synta Pharma 2002 Tolerance Pharma* Transvascular W3 Health *Company formed around Beth Israel Deaconess Medical Center platform technology. Fri, 28 Aug 2009 20:37:53 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice/TVOIntheNews.aspx Technology Ventures Office In The News Fri, 28 Aug 2009 20:39:02 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice/OtherResources.aspx Informational links related to the Technology Ventures Office Mon, 16 Mar 2009 19:33:40 GMT http://bidmc.org/Research/ResearchandAcademicAffairs/TechnologyVenturesOffice/ContactUs.aspx Contact information for the Technology Ventures Office at Beth Israel Deaconess Medical Center. Wed, 13 May 2009 20:55:13 GMT http://bidmc.org/Research/Departments.aspx Research by Department at BIDMC. Thu, 30 Jul 2009 20:41:38 GMT http://bidmc.org/Research/Departments/AnesthesiaCriticalCareandPainMedicine.aspx Advancing the science of anesthesiology by generating new knowledge is part of the mission of the Department of Anesthesia and Critical Care of the Beth Israel Deaconess Medical Center. Consistent with this goal, many of our faculty are actively involved in a wide array of ongoing clinical and laboratory research projects. A summary of some of these projects is included on this website. Mon, 25 Aug 2008 15:15:17 GMT http://bidmc.org/Research/Departments/EmergencyMedicine.aspx The International Emergency Medicine Program at BIDMC strives to promote the growth of academic programs and clinical excellence in Emergency Medicine worldwide. Its other goals are to foster international collaboration and to provide assistance to members of the international community to develop Emergency Medicine within the context of the healthcare needs of their own countries. Current active projects involve Emergency Medicine systems in Russia, Europe, Central and South America, as well as CME programs in Italy. The International Emergency Medicine program has also recently received grant funding from the United Nations to promote Emergency Medicine worldwide. Wed, 23 Jul 2008 23:12:47 GMT http://bidmc.org/Research/Departments/EmergencyMedicine/InternationalDisasterandEmergencyMedicineProgram.aspx The goals of the Division of International Disaster and Emergency Medicine (DIDEM) within the Department of Emergency Medicine at Beth Israel Deaconess Medical Center are to work with a broad spectrum of international partners to: build local capacity for emergency medical care delivery and disaster medical response around the world advance the specialties of disaster and emergency medicine worldwide provide high-level continuing medical education in DM and EM for the international medical community Thu, 17 Jul 2008 13:03:15 GMT http://bidmc.org/Research/Departments/Medicine.aspx The Department of Medicine at Beth Israel Deaconess Medical Center provides a comprehensive program of clinical services encompassing general internal medicine and all the subspecialties of internal medicine, covering the gamut of services from primary to tertiary care. Tue, 04 Aug 2009 18:44:56 GMT http://bidmc.org/Research/Departments/Medicine/Divisions.aspx The Department of Medicine is organized into 24 Divisions. Research in the Divisions spans the gamut from basic biomedical science, through epidemiology, health services, health policy and population-based research, to clinical trials and the development of new devices. Links to Divisional Research pages can be found in the left navigation bar. Tue, 04 Aug 2009 18:58:48 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/AllergyandInflammation.aspx The Cellular and Molecular Bases of Inflammation - This laboratory, directed by Dr. Peter Weller, has many active areas of basic laboratory research centered around understanding basic mechanisms of leukocyte functioning in forms of inflammation. The two principal areas of investigation are: 1) the immunobiology of eosinophilic leukocytes and 2) the intracellular regulation and compartmentalization of inducible mediators of inflammation in neutrophils and other leukocytes. Wed, 18 Nov 2009 20:19:02 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/CardiovascularMedicine.aspx Members of the Cardiovascular Division pursue a wide variety of research, ranging from basic investigations on the biology of atherogenesis to the development of thrombolytic therapy for patients with acute myocardial infarction. Major areas of clinical and basic research interest among the faculty include: hemodynamics, signal transduction and excitation-contraction coupling in cardiac and vascular myocytes, cardiac hypertrophy and heart failure, interventional cardiology, lipids and atherosclerosis, cardiomyopathy and myocarditis, thrombolysis in myocardial ischemic syndrome, thrombosis and vascular biology, molecular and cellular cardiology, aging and cardiovascular homeostasis, clinical epidemiology and biostatistics (including the Framingham Heart Study), clinical trials design and management, echocardiography and non-invasive imaging, electrophysiology, exercise physiology/nuclear medicine, and magnetic resonance imaging. Wed, 18 Nov 2009 20:19:02 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/ClinicalInformatics.aspx The Division of Clinical Informatics, created over 30 years ago by Drs. Howard Bleich and Warner Slack, was among the first academic divisions in the world to concentrate on the use of computers for patient care, teaching, and medical research. Mon, 25 Aug 2008 23:12:17 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/ClinicalNutrition.aspx The Division of Clinical Nutrition has been widely acknowledged as one of the principal training sites in enteral and parenteral nutrition in the United States for the past two and a half decades and a major contributor to clinical nutrition research over the past 30 years Wed, 18 Nov 2009 20:19:01 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/Endocrinology.aspx The Division of Endocrinology is involved in a broad array of research initiatives supported by NIH, private foundations, and the pharmaceutical industry. The work ranges from clinical trials to physiology to basic investigations of gene structure and function, cell signaling, gene transcription, mouse genetics and hormone resistance. Wed, 18 Nov 2009 20:19:01 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/ExperimentalMedicine.aspx Led by Dr. Jerome Groopman, the Division of Experimental Medicine is currently conducting research HIV Biology, Immunology, and Endothelial Biology, Molecular Signaling in Breast Cancer, Molecular Virology and Gene Therapeutics, Neurobiology, Structural Biology and Gene Regulation. Wed, 18 Nov 2009 20:19:02 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/Gastroenterology.aspx Beth Israel Deaconess Medical Center gastrointestinal physicians and surgeons are nationally recognized for contributions to the future of digestive disease care through their studies and publications, as well as training Harvard Medical School students and providing graduate medical education. Wed, 18 Nov 2009 20:19:04 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/GeneralMedicineandPrimaryCare.aspx The Division supports a diverse research program led by Dr. Edward R. Marcantonio, Director of Research, and Dr. Christina Wee, Co-Director of Research. Our research mission is to conduct interdisciplinary patient-centered research focused on preventing and treating health conditions to maximize patients' quality of life and functional independence. We conduct this research within a collegial environment featuring mentorship and training. The research program consists of 13 core research faculty-nine clinician-investigators, two epidemiologists, and two biostatisticians-and several adjunct research faculty. The Division conducts research in several areas including work in aging, cancer, cardiovascular health, complementary and alternative medicine, end of life and palliative care, health disparities, and obesity. We employ a variety of research methodologies including secondary analysis of large databases, qualitative methods, and traditional quantitative research methods such as surveys, observational and analytic epidemiology, and interventional trials. In addition, the Division is committed to research that improves healthcare quality and delivery and has ongoing initiatives in the areas of health care innovations and quality improvement. The Division's investigations hold both clinical implications and relevance for public health and health services delivery, locally and nationwide. The total extramural support for our research program is growing and in FY'06 exceeded $6.5 million. Wed, 15 Jul 2009 19:33:02 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/Genetics.aspx The Division of Genetics is focused on understanding how alterations in our genes contribute to the development of disease Tue, 16 Sep 2008 13:17:57 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/Gerontology.aspx The Division of Gerontology is conducting research in the following areas: Basic Research Mitochondrial Function Neurodegenerative Diseases Clinical Research Delirium End of Life Care Falls, Syncope and Blood Pressure Regulation Home Care Osteoporosis Pain Assessment and Management Physical Function and Disability Physiological Research Cardiovascular and Cardiopulmonary Physiology Wed, 18 Nov 2009 20:19:03 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/HematologyOncology.aspx The research activities of the Division of Hematology/Oncology have continued to prosper. Cancer and hematology research at the BIDMC is centered in the Hematology/Oncology Division. The breadth of scientific inquiry includes: the molecular biology of hematopoiesis in normal and malignant cells, cell cycle regulation, oncogenes, transcription factors, iron metabolism, anemia, bone marrow transplantation, drug discovery, cellular immunology and immunotherapy (vaccine development, adoptive immunotherapy, genetic modification of T cells), and breast, kidney, skin, lung, gastrointestinal and prostate cancer biology. Wed, 18 Nov 2009 20:19:04 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/HemostasisandThrombosis.aspx The division of hemostasis and thrombosis is focused on understanding and treatment of bleeding and thrombotic disorders. Hematologists with a special interest in disorders of blood coagulation diagnose and manage patients with acquired and hereditary disorders (e.g., hemophilia) and thrombotic diseases that cause deep venous thrombosis and pulmonary embolism. Wed, 18 Nov 2009 20:19:04 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/Immunology.aspx The Immunology Division at Beth Israel Deaconess Medical Center conducts basic research of innate and adaptive immune responses using knockout and knock-in approaches. The goals of the Division are: 1) to carry out cutting-edge basic research of innate and adaptive immune responses; 2) to teach graduate students and Research Fellows and 3) to provide a nurturing environment for the career development of Research Fellows and Faculty. The Division employs 2 research faculty, 7 research fellows, 1 graduate students and 3 research technicians. Wed, 18 Nov 2009 20:18:59 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/InfectiousDisease.aspx The research programs of the Division cover a broad range of important clinical and laboratory areas including: AIDS Clinical Trial Group HIV Transplantation Program Faculty Clinical Research Profiles Basic Investigators Research Profiles Wed, 18 Nov 2009 20:19:00 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/InterdisciplinaryMedicineandBiotechnology.aspx The Division of Interdisciplinary Medicine and Biotechnology (IMBIO) is a newly formed division, perhaps the first of its type to be housed within a clinical department. IMBIO is organized under the leadership of Dr. Sukhatme as division director and Dr. A. Goldberger as the associate director. The Division has both research and educational missions at BIDMC, at Harvard Medical School and its affiliated hospitals and with Harvard University, especially the Allston initiative. It anticipates many interfaces with other institutions both locally (such as MIT) and nationally. Wed, 18 Nov 2009 20:19:00 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/MatrixBiology.aspx The Division of Matrix Biology at Beth Israel Deaconess Medical Center, was recently established in March 2006, and is the first of its kind in the country to reside within a Department of Medicine and unique in its combination of matrix research and clinical medicine. Matrix biology is the study of extracellular matrix (ECM) and its communication with cells. Where cells are present, matrix is also present, throughout the human body. This area of biology is gaining wide prominence as a key structural and functional regulator of organ function. Wed, 18 Nov 2009 20:18:59 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/MolecularandVascularMedicine.aspx The Division of Molecular Medicine was created in 1989 at the BIDMC to foster hospital-based basic and translational sciences. Recognizing the emergence of vascular biology as a critical area of research and development, the division was renamed Molecular and Vascular Medicine in 1993. The goal of the Division is to create the first-of-its-kind bench-to-bedside program in vascular/endothelial biomedicine. The strategic plan of the Division is focused on three complementary areas: 1) basic science research, 2) translational research, and 3) clinical care. The Division of Molecular and Vascular Medicine complements and interacts closely with the existing inter-departmental hospital wide Center for Vascular Biology Research. Sun, 14 Sep 2008 20:13:16 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/Nephrology.aspx Research activities in the Nephrology Division are carried out at every level, including patients with renal disease, normal volunteers, animals, isolated and cultured cells, and the molecular messages and mechanisms influencing cell behavior. Research categories include: physiology and treatment of acute renal failure, hormonal and neuroendocrine control of salt and water excretion, cellular transduction mechanisms, molecular mechanisms of cell injury and protection against cell injury, the molecular basis for the transport of anions and cations across cell membranes, mechanisms of muscle wasting and intracellular protein breakdown, cellular immunology (especially those aspects involved in organ transplantation), mammalian gene regulation, kidney development, gene therapy to the kidney, kidney cancer, angiogenesis and fibrosis, bladder function and water transport across bladder epithelial membranes. An NIH research training grant supports several basic science and clinical fellowship positions. Fellows in their research years may conduct studies in laboratories within or outside of Beth Israel Deaconess Medical Center. Tue, 11 Nov 2008 19:26:24 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/Pulmonology.aspx The BIDMC Division of Pulmonary, Critical Care and Sleep Medicine conducts innovative basic science and clinical research. These internationally recognized investigators supervise a variety of research programs including active research in the areas of the physiology and neurobiology of sleep, physiology and response of the body to the stress of hypoxia (low oxygen levels in the blood), and lung immune cell biology and function in healthy and disease. Research is conducted through funds from the National Institutes of Health (NIH), non-Federal and educational grants. Wed, 18 Nov 2009 20:19:00 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/Rheumatology.aspx The Division has a very active and expansive basic and clinical research program in the field of Systemic Lupus Erythematosus headed by Dr. Tsokos. The laboratory, which consists of over 6,000 square feet of bench space, is located in the Clinical Life Science Building. Wed, 18 Nov 2009 20:19:00 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/SignalTransduction.aspx The Division of Signal Transduction is conducting research in the following areas: Cell Signaling Growth Factors and Receptor Tyrosine Kinases Phosphoinositide Kinases Signal Transduciton and Cancer Metabolism Wed, 18 Nov 2009 20:19:01 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/TranslationalResearch.aspx The Division of Translational Research at BIDMC provides a unique “home” for faculty who play a major role in the infrastructure for clinical/translational investigation. Dr. Steven Freedman, the Chief of the Division of Translational Research at BIDMC, is also the Co-Director of Harvard Catalyst, co-director of the Harvard and the Associate Dean and Dean for Clinical and Translational Research at Harvard Medical School. The Harvard Catalyst, a pan-Harvard enterprise made possible by funding of the Harvard CTSC, will provide not only the funding but the mechanisms critical to create interdisciplinary teams within and across institutions. BIDMC and the Division of Translational Research will play a major role in Harvard Catalyst initiatives. Fri, 12 Sep 2008 21:16:30 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/TransplantImmunology.aspx The overarching research goal of the Division is to map a pathway to create immune tolerance in the clinic for patients in need of organ or islet transplants. The T cell response to MHC mismatched allografts includes both the usually large CD4+ and CD8+ pool of graft destroying effector T cells and a much smaller pool of graft protecting suppressor of regulatory T cells. The outcome of the allograft response, rejection or tolerance, is determined by the nature of the T cells, effector or regulatory, that are ascendant in the allograft recipient. Wed, 18 Nov 2009 20:19:00 GMT http://bidmc.org/Research/Departments/Medicine/Divisions/ViralPathogenesis.aspx The Division of Viral Pathogenesis includes a team of immunology laboratories studying the basic and clinical immunopathology of AIDS and primate retroviral infections. A major component of our research effort utilizes the simian immunodeficiency virus (SIV) infection of macaque monkeys as an animal model for AIDS. Wed, 18 Nov 2009 20:19:00 GMT http://bidmc.org/Research/Departments/Medicine/CenterforVascularBiology.aspx The Center for Vascular Biology Research will promote interdisciplinary communication and collaboration to enhance vascular biology research, from basic to translational. The Center will transcend traditional barriers between specialty areas and will encourage clinicians and scientists to formulate creative approaches to the study of vascular biology. By training the leaders of tomorrow in vascular biology, the Center will work towards a goal of improved care. Fri, 06 Nov 2009 22:16:59 GMT http://bidmc.org/Research/Departments/Medicine/CenterforVascularBiology/Governance.aspx The Center for Vascular Biology Research is supported by the Departments of Medicine, Emergency Medicine and Pathology. The Center is led by a Director. The Director, in turn reports to an Executive Committee comprising the Chairs of the three Departments. Thu, 12 Nov 2009 18:22:02 GMT http://bidmc.org/Research/Departments/Medicine/CenterforVascularBiology/AreasofResearch.aspx The Center's researchers and clinician-scientists focus on three traditional themes of vascular biology research. Sun, 14 Sep 2008 16:14:04 GMT http://bidmc.org/Research/Departments/Neonatology.aspx Our vision for research in the BIDMC Department of Neonatology is to discover and refine the best ways to care for patients and their families. This is an activist, pragmatic vision that derives from our strengths as clinicians and clinical researchers. Thu, 24 Jul 2008 00:49:11 GMT http://bidmc.org/Research/Departments/Neurology.aspx Neurology is one of the most exciting areas of medicine because so much new is being discovered every day about the brain, how it works, and what happens when it does not work (and what to do about it). The Department of Neurology at Beth Israel Deaconess Medical Center is proud to be at the forefront of this revolution. We have distinguished research laboratories and clinical research programs in each of the major areas of neurology. Wed, 25 Mar 2009 16:56:04 GMT http://bidmc.org/Research/Departments/Neurology/MeetOurResearchFaculty.aspx Neurology Research Faculty Sun, 01 Nov 2009 22:13:54 GMT http://bidmc.org/Research/Departments/Neurology/CerebrovascularDisease.aspx The Division of Cerebrovascular Disease is conducting research in Neuroprotection. Thu, 17 Jul 2008 13:02:49 GMT http://bidmc.org/Research/Departments/Neurology/CognitiveNeurology.aspx The Division of Cognitive Neurology at BIDMC. Tue, 02 Sep 2008 03:48:12 GMT http://bidmc.org/Research/Departments/Neurology/CognitiveNeurology/ClinicalResearch.aspx Clinical Rearch in the Division of Cognitive Neurology at BIDMC Mon, 25 Aug 2008 21:28:02 GMT http://bidmc.org/Research/Departments/Neurology/Epilepsy.aspx The Division of Epilepsy is conducting research in Cognitive Evoked Potential Research Laboratory, Experimental Anticonvulsant Research Unit, Laboratory of Neurogenetics, and the Neurophysiology Engineering Laboratory. Thu, 17 Jul 2008 13:03:00 GMT http://bidmc.org/Research/Departments/Neurology/GeneralNeurology.aspx The Division of General Neurology is conducting research in Systems Neuroscience Laboratory Group, Human Vision and Eye Movement, Laboratory of Pain Research, and the HIV/Neurology Center. Thu, 17 Jul 2008 13:03:06 GMT http://bidmc.org/Research/Departments/Neurology/Genetics.aspx The Division of Neurogenetics is conducting research in Laboratory of Neurogenetics and Human Mitochondrial DNA Laboratory. Thu, 17 Jul 2008 13:03:06 GMT http://bidmc.org/Research/Departments/Neurology/HIVNeurologyCenter.aspx The HIV/Neurology Center offers comprehensive care for acute and chronic neurological problems in people with HIV infection or AIDS. The center is staffed by physicians who have received specialized training in this field and who are on the faculty at Harvard Medical School. As a patient of our center, you will have access to the most sophisticated treatments available, and be able to participate in current clinical treatment trials. In addition, we will assist you in getting more information about your condition with the help of Beth Israel Deaconess Learning Center. Tue, 31 Mar 2009 18:40:48 GMT http://bidmc.org/Research/Departments/Neurology/MovementDisorders.aspx Members of our staff are actively engaged in clinical and laboratory research into the cause and treatment of Parkinson's disease, tremor, dystonia, and related movement disorders. This includes clinical trials of new medical and surgical treatments, clinical and laboratory investigations into genetics, brain physiology, and brain chemistry underlying these movement disorders, new brain imaging techniques, and anatomic studies of the brain pathways which underlie these disorders. Wed, 25 Mar 2009 16:43:55 GMT http://bidmc.org/Research/Departments/Neurology/MovementDisorders/DavidK,-d-,SimonLab.aspx The David K. Simon laboratory focuses on the pathogenesis of Parkinson’s disease (PD), including studies of mechanisms of neurodegeneration as well as translational studies of potential neuroprotective strategies. Wed, 25 Mar 2009 17:00:49 GMT http://bidmc.org/Research/Departments/Neurology/MovementDisorders/PrograminHumanBasalGanglionResearch.aspx The Program in Human Basal Ganglion Research is a division of the Laboratory of Integrative Neurobiology. Research examines the chemical neuroanatomy of the human basal ganglion system, both in normal brains, and in the brains of people who have died with movement disorders. Projects examine both the central catecholaminergic system in Parkinson's disease, as well as the chemical compartmentalization of the human striatum. We are particularly interested in correlating the changes that occur in basal ganglion organization with the widely varied clinical courses of patients with movement disorders, to determine the role played by specific circuits in movement control and its dysfunction. Wed, 25 Mar 2009 15:56:36 GMT http://bidmc.org/Research/Departments/Neurology/NeuromuscularDisease.aspx We have a varied selection of research in the division, ranging from basic science work in the field of diabetic neuropathy to clinical trial in amyotrophic lateral sclerosis. Tue, 02 Sep 2008 03:48:34 GMT http://bidmc.org/Research/Departments/Neurology/NeuromuscularDisease/ElectricalImpedanceMyography.aspx Electrical impedance myography (EIM) is a novel technique under development for the assessement of neuromuscular disease. Based on bioimpedance concepts, EIM involves the application of high-frequency, low-intensity electrical current via surface electrodes and measurement of the consequent voltages via a second set of electrodes. With knowledge of the magnitude of the applied current, an impedance instrument converts these voltage signals into two parameters, the resistance (R) and reactance (X). From these, a third parameter, the spatially averaged phase (Θavg ) can be computed. This parameter is less sensitive to effects of muscle shape and size and has proved useful for evaluation of muscle disease and health. EIM measurements also allow calculation of the effective resistivitiy (ρeff ), a measure of the intrinsic electrical properties of skeletal muscle. Fri, 12 Sep 2008 19:54:29 GMT http://bidmc.org/Research/Departments/Neurology/NeuromuscularDisease/LumbosacralPlexitis.aspx Lumbosacral plexitis is a rare neurological condition. In this disease, inflammation and swelling affect the region of the hip where the nerve roots emerging from the spinal cord crisscross and interconnect. One version occurs in diabetic patients (also known as diabetic amyotrophy) and another, rarer condition occurs in non-diabetic patients (also known as idiopathic lumbosacral plexitis). The disease begins with flu-like symptoms that are followed by excruciating proximal leg and hip pain, and then over a period of several weeks, by progressive weakness, sensory loss, and muscle atrophy. The disease may resolve itself spontaneously over several months, or can persist for years if left untreated. Current treatment includes a variety of immune-modulating therapies including IVIG, plasmapheresis, corticosteroids, and other drug regimens. The time course of recovery is quite prolonged, with many individuals not regaining full strength until 2 years or more after the initial onset of symptoms. Persistent weakness, atrophy, and sensory loss may still remain after treatment. Thu, 10 Sep 2009 14:17:30 GMT http://bidmc.org/Research/Departments/Neurology/NeuromuscularDisease/TemperatureandDiabeticPolyneuropathy.aspx Diabetic Neuropathy (DN) is one of the most common complications of diabetes mellitus, affecting milllion Americans. The irreversible effects of neuropathy include severe pain and paresthesias leading to disabled movement and amputation. Many patients with diabetic neuropathy complain of temperature related symptoms and for theoretical reasons, exposure to intermittent cold could adversely affect nerve function over the long-term. We have a long-term research interest in exploring the connections between temperature and the development and symptoms of diabetic neuropathy. Fri, 12 Sep 2008 20:05:54 GMT http://bidmc.org/Research/Departments/Neurology/Neurooncology.aspx Neruo-oncology research in the Neurology Department at BIDMC. Thu, 17 Jul 2008 13:03:26 GMT http://bidmc.org/Research/Departments/Neurology/NeuropathologyandDemyelinatingDisorders.aspx The Division of Neuropathology is conducting research in Oligodendrocyte Biology and Multiple Sclerosis Genetics Thu, 17 Jul 2008 13:03:27 GMT http://bidmc.org/Research/Departments/Neurology/Neurorehabilitation.aspx The Division of Neurorehabilitation is conducting research in Cortical Response to Injury and in Neuronal Injury and Apoptosis. Tue, 02 Sep 2008 20:45:55 GMT http://bidmc.org/Research/Departments/Neurology/SleepDisorders.aspx The Division of Sleep Disorders is conducting research in Mechanisms of Regulation of Sleep and Clinical Sleep Research. Tue, 02 Sep 2008 03:48:34 GMT http://bidmc.org/Research/Departments/Neurology/SleepDisorders/PrograminMechanismsofRegulationofSleep.aspx The Program in the Mechanisms in the Regulation of Sleep represents a collaboration between the Laboratory of Integrative Neurobiology and the Division of Sleep Disorders. The basic science component of this program uses electrophysiological and neuroanatomical techniques to dissect the circuitry within the brain that regulates wake-sleep cycles. Current work is focused upon a recent finding from this laboratory, that there is a specific group of nerve cells in the ventrolateral preoptic area which is the only cluster of neurons in the brain that demonstrates increased activity (as measured by expression of the Fos protein) during sleep. These neurons have connections with the major arousal systems of the brain and use inhibitory neurotransmitters, and they may serve as a central switching mechanisms for turning off the arousal systems to allow sleep to occur. We are currently investigating the mechanisms that may drive the ventrolateral preoptic area to cause sleep. Tue, 02 Sep 2008 20:21:45 GMT http://bidmc.org/Research/Departments/Neurology/StrokeCenter.aspx The Comprehensive Center for Stroke and Cerebrovascular Diseases at Beth Israel Deaconess Medical Center (BIDMC) has a long-standing history of providing excellent care for patients with ischemic and hemorrhagic stroke, and brain aneurysms throughout the United States, and is one of the premier centers for cerebrovascular diseases worldwide. The Center offers the full range of medical, surgical and interventional capabilities with 24 hour-a-day, 7 day-a-week access to state-of-the-art neuroimaging, neurointerventional and endovascular care. Tue, 02 Sep 2008 03:48:34 GMT http://bidmc.org/Research/Departments/Neurology/StrokeCenter/ClinicalTrials.aspx Current Clinical Trial at BIDMC Stroke Center. Thu, 17 Jul 2008 13:02:52 GMT http://bidmc.org/Research/Departments/Neurology/Laboratories.aspx There are numerous laboratory studies underway within the Department of Neurology at Beth Israel Deaconess Medical Center. Wed, 25 Mar 2009 16:54:52 GMT http://bidmc.org/Research/Departments/Neurology/Laboratories/MatthewAndersonLab.aspx Matthew P. Anderson, M.D., Ph.D., is an Assistant Professor and Principal Investigator in the Departments of Neurology and Pathology at Beth Israel Deaconess Medical Center, an affiliate of Harvard Medical School. Tue, 02 Sep 2008 20:19:59 GMT http://bidmc.org/Research/Departments/Neurology/Laboratories/BernardChangLab.aspx This is Bernard Chang's Lab webpage describing work on cortical malformations Tue, 07 Oct 2008 21:32:59 GMT http://bidmc.org/Research/Departments/Neurology/Laboratories/DanielPressLab.aspx Our lab investigates motor learning and consolidation. Using a combination of functional brain imaging, transcanial magnetic stimulation (TMS) and behavioral paradigms, we probe the neural basis of “off-line learning”, or improvements in skill between sessions, in the absence of practice. We study the effects of neurological conditions such as Parkinson’s disease and Alzheimer’s disease on motor learning. By understanding the neural systems subserving motor learning, we hope to improve Tue, 10 Feb 2009 20:44:54 GMT http://bidmc.org/Research/Departments/Neurology/Laboratories/DavidKSimonLab.aspx The laboratory focuses on the pathogenesis of Parkinson’s disease (PD), including studies of mechanisms of neurodegeneration as well as translational studies of potential neuroprotective strategies. Wed, 05 Aug 2009 19:32:57 GMT http://bidmc.org/Research/Departments/Neurology/Laboratories/JunLu.aspx This is the Long Description. Fusce ut odio vel lectus luctus venenatis. Nulla sagittis faucibus lorem. Sed enim ipsum, ornare eu, semper eget, cursus id, dolor. Curabitur vel leo a turpis pulvinar consequat. Nulla facilisi. Quisque eu felis. Cras fringilla felis at metus. Fri, 20 Nov 2009 22:02:48 GMT http://bidmc.org/Research/Departments/Neurology/Laboratories/NancyChamberlinLab.aspx Dr. Nancy L. Chamberlin is an assistant professor in the Department of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School. Her laboratory is one of a cluster of Systems Neurobiology laboratories at Beth Israel Deaconess Medical Center and Harvard Medical School. Her focus is on regulation of sleep, breathing and the effects of general anesthetics on these systems. Tue, 31 Mar 2009 19:11:14 GMT http://bidmc.org/Research/Departments/Neurology/Laboratories/BerensonAllenCenterforNoninvasiveBrainStimulation.aspx At the Berenson-Allen Center for Noninvasive Brain Stimulation (CNBS) at Beth Israel Deaconess Medical Center and Harvard Medical School we have three distinct missions: Research, Education, Patient Care. Research explores brain-behavior relations, brain plasticity and its modulation, employing different noninvasive brain stimulation techiques combined with careful task design, electroencephalography, and functional brain imaging. Educational efforts feature a week long intensive course in noninvasive brain stimulation offered three times per year as part of Harvard’s Continuing Medical Education program. Clinical work includes studies of central motor conduction time, cortical excitability, noninvasive determination of hemispheric dominance for language, and noninvasive cortical mapping. In addition, our clinical program offers noninvasive brain stimulation for treatment of neuropsychiatric disorders such as depression and schizophrenia, epilepsy, dystonia, Parkinson’s disease, chronic pain, and the neurorehabilitation of hand function and language after stroke. Thu, 26 Feb 2009 21:31:06 GMT http://bidmc.org/Research/Departments/Neurology/Laboratories/CliffordSaperLab.aspx Dr. Clifford Saper is the Chairman of the Department of Neurology at Beth Israel Deaconess Medical Center, the James Jackson Putnam Professor of Neurology at Harvard Medical School, and a faculty member of the Program in Neuroscience. Our laboratory is one of a cluster of Systems Neurobiology laboratories at Beth Israel Deaconess Medical Center and Harvard Medical School. Our focus is on basic functions of the nervous system, such as sleeping and thermoregulation, which are regulated by the hypothalamus. Thu, 18 Sep 2008 15:06:59 GMT http://bidmc.org/Research/Departments/Neurology/Laboratories/VolneySheenLab.aspx Our laboratory has two central areas of investigation: 1) Generation and characterization of ventricular zone-derived human neural stem cells from developmental disorders of the central nervous system. 2) Study of inherited disorders of cortical development, resulting from disruption of developmental processes along the ventricular zone. Tue, 12 Aug 2008 19:02:25 GMT http://bidmc.org/Research/Departments/ObstetricsGynecology.aspx Beth Israel Deaconess Medical Center is a major research affiliate of Harvard Medical School and ranks fourth among independent hospitals nationwide in National Institutes of Health funding. Through close collaboration with other departments at the medical center and at Harvard Medical School, the department has a varied and prolific research program. Thu, 05 Nov 2009 23:42:46 GMT http://bidmc.org/Research/Departments/ObstetricsGynecology/IVFResearch.aspx Clinical research in the Division of Reproductive Endocrine and Infertility has focused on clinical outcomes in various aspects of ART. Michele Hacker, ScD, MSPH and Dr. Alan Penzias have lead efforts to perform rigorous analysis of the Boston IVF patient database which contains records on more than 35,000 IVF cycles. In 2009 the results of one of their studies was published in the New England Journal of Medicine (Malizia BA, Hacker MR, Penzias AS. Cumulative live-birth rates after in vitro fertilization. N Engl J Med 2009; 360:236-43). Thu, 05 Nov 2009 15:28:42 GMT http://bidmc.org/Research/Departments/ObstetricsGynecology/PreeclampsiaHypertensiveDisordersinPregnancy.aspx A collaboration between the Department of Obstetrics and Gynecology and the Department of Medicine at Beth Israel Deaconess Medical Center has resulted in several major breakthroughs in preeclampsia research. Preeclampsia affects 200,000 pregnancies a year in the United States and often leads to premature births. Preeclampsia complicates 5 percent of all pregnancies and is a major cause of maternal and fetal mortality worldwide. Severe preeclampsia is one of the world’s leading causes of maternal and fetal mortality. Under the direction of renal specialist S. Ananth Karumanchi, M.D., Assistant Professor in Medicine and Obstetrics and Gynecology, Harvard Medical School, and collaborating with Maternal Fetal Medicine specialists Kee Hack Lim and Benjamin Sachs, this research team has discovered key pieces of evidence that help to diagnose, and eventually treat, this disease. Thu, 05 Nov 2009 15:13:11 GMT http://bidmc.org/Research/Departments/ObstetricsGynecology/SimulationResearch.aspx Residents participate in a gynecologic surgical simulation program that includes the Fundamentals of Laparoscopic Surgery (FLS). Dr. Hye-Chun Hur, Co-director of the Minimally Invasive Surgery Program, is evaluating this program as assessment tool for surgical competence. The FLS program consists of a cognitive and psychomotor skills component, and is a joint educational effort initiated by SAGES, and supported by the American College of Surgeons. Residents have 24-hour access to our on-site simulation laboratory and to the SAGES-FLS 2-part CD-rom that reviews topics and skills for safe laparoscopic practice. The gynecologic faculty meet monthly with the residents for a proctored group practice session to provide feedback. Thu, 05 Nov 2009 16:02:07 GMT http://bidmc.org/Research/Departments/ObstetricsGynecology/StemCellResearch.aspx Our division has enhanced our existing collaboration with the Harvard Stem Cell Institute and the Harvard University Department of Stem Cell and Regenerative Biology. Kevin Eggan, PhD directs a laboratory whose focus is how developmental and environmental cues induce heritable variation in chromatin structure and how these variations regulate developmental potency, cell-fate and gene expression. In addition, the Eggan lab uses nuclear transfer and other approaches to develop human embryonic and induced pluripotent stem cell lines that carry the genes responsible for human neurodegenerative disease. Dr Eggan’s publication “Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons” (Science 2008; 321(5893):1218-21) was cited by Time Magazine as the Top Medical Breakthrough of 2008. Thu, 05 Nov 2009 15:29:01 GMT http://bidmc.org/Research/Departments/ObstetricsGynecology/GlobalHealth.aspx The department is committed to improving women’s health and working toward eliminating health care disparities worldwide. Department leaders have developed programs and raised funds for women health centers in a number of developing countries, and is committed to education of physicians and healthcare workers internationally. These programs represent our commitment to healthcare for all women and children in the world and are part of our mission. Funded through multiple sources, including the BIDMC OB/GYN Foundation, USAID, Harvard Humanitarian Initiative, and philanthropy, this work enhances our own ability to provide health care and to teach our residents and medical students the principles of culturally competent care. Residents are encouraged to participate in service-based learning research projects in the international arena during their second and third year elective time. In recent years, residents have traveled to Congo, India, Ethiopia, Mexico, China, Taiwan, United Kingdom, and Vienna. Thu, 05 Nov 2009 23:40:09 GMT http://bidmc.org/Research/Departments/ObstetricsGynecology/OvarianAging.aspx Dr. Reindollar earned his M.D. degree from the Bowman Gray School of Medicine in Winston Salem, NC. He completed his residency in obstetrics and gynecology at York Hospital, York, PA, and completed a fellowship in reproductive endocrinology and genetics at Medical College of Georgia, Augusta, GA.. Dr. Reindollar has been awarded numerous citations for excellence in teaching and is the past-president of the Society of Reproductive Endocrinologists, and the Boston Fertility Society. He is also a founding fellow of the American College of Medical Genetics, a past-president of the North American Society for Pediatric and Adolescent Gynecology, and a member of many other professional organizations. He has published a great number of articles in professional medical journals, as well as abstracts and invited book chapters, and has lectured extensively at postgraduate courses and seminars. Thu, 05 Nov 2009 15:10:38 GMT http://bidmc.org/Research/Departments/ObstetricsGynecology/ResidentAsTeacher.aspx Dr’s Hope Ricciotti and K. Meredith Atkins lead the OBGYN Resident as Teacher Program, which uses simulated medical student teaching encounters to train residents to be better teachers in an annual videotaped session, and formally assesses the teaching skills of residents. A study is underway to examine this method as an assessment tool of resident teaching and communication skills. Thu, 05 Nov 2009 15:46:08 GMT http://bidmc.org/Research/Departments/ObstetricsGynecology/OpticalDiagnosisInOBGYN.aspx Prior to coming to the BIDMC, Dr. Perelman was a Principal Scientist at the MIT Laser Biomedical Research Center where his research interest was using optical spectroscopy to diagnose disease. He conceived and developed biomedical light scattering spectroscopy (LSS) recently applied for non-invasive detection of early precancerous changes in epithelial tissues and tissue characterization on sub-cellular scale. His present research interest involves application of optics to cell biology and detection of disease. Thu, 05 Nov 2009 15:36:57 GMT http://bidmc.org/Research/Departments/ObstetricsGynecology/Radiology.aspx Deborah Levine, M.D., is a Professor of Radiology and Obstetrics and Gynecology at Harvard Medical School and BIDMC. She is also co-chief of ultrasound and director of OB/GYN ultrasound. Dr. Levine’s research interest is improving prenatal diagnosis with use of obstetric MRI. Funded by an NIH R01 grant entitled “MRI of Fetal Ventriculomegaly: Morphology and Outcome.” This research project evaluates fetal central nervous system anomalies seen on MRI and compares them with ultrasound, in order to correlate imaging findings with postnatal outcomes. Thu, 05 Nov 2009 16:59:27 GMT http://bidmc.org/Research/Departments/ObstetricsGynecology/EpidemiologicResearchProgram.aspx Program in Epidemiologic Research Michele Hacker, ScD, MSPH Program Director Laura Dodge, MPH Research Assistant Beth Israel Deaconess Medical Center is a major research affiliate of Harvard Medical School and ranks fourth among independent hospitals nationwide in National Institutes of Health funding. Through close collaboration with other departments at the medical center and at Harvard Medical School, the department has a varied and prolific research program. Our faculty, fellows, residents, and students are guided by the expertise of our department epidemiologist, Dr. Michele Hacker, who ensures that all of our research endeavors are of the highest quality, and that patients’ rights are protected. The Program in Epidemiologic Research supports the many research studies throughout the Department. These studies range from basic science research to focus groups to placebo-controlled randomized clinical trials and often include collaborations with other departments. The Program provides assistance with all elements of the research process, including study design, study implementation, data analysis and manuscript preparation, as well as grant writing. This resource is available to all members of the department to encourage and support their active engagement in research. In particular, the Program aims to foster and advance the research endeavors of residents and fellows. We are very proud of our clinical, basic science, public health, and educational research projects, which reflect the diversity that is valued in our department. The residents and fellows have successfully conducted a variety of research projects that have led to presentations at national meetings and publications in peer-reviewed journals. Completed and ongoing studies include outcomes following in vitro fertilization, neonatal morbidity among early elective cesarean deliveries, embryo morphology and aneuploidy, timing of antibiotics for cesarean section, sexual satisfaction after hysterectomy, and simulation training for minimally invasive surgery and obstetric complications. Our interdepartmental collaborative efforts are the basis of several successful research developments as well, and they allow significant advances in our understanding of disease and the delivery of health care. Our collaborations on the pathogenesis of preeclampsia have led to exciting research findings and new potential clinical therapies. An ongoing study of gene expression in pregnancies complicated by intrauterine growth restriction holds similar promise. The Department also places special emphasis on epidemiology and public health policy as it relates to women’s health both in the United States and internationally. One of our chief residents has recently completed research on sexual violence and unintended pregnancies in the Democratic Republic of the Congo, and will continue to work in the area with the Harvard Humanitarian Initiative. Another resident is currently investigating knowledge of and attitudes about cervical cancer and HPV vaccination among women in Zambia. Ongoing faculty research includes studies on maternal morbidity and contraceptive use by couples in Afghanistan and the role of angiogenic factors in patients with gestational trophoblastic disease in the Philippines. Thu, 05 Nov 2009 15:52:14 GMT http://bidmc.org/Research/Departments/ObstetricsGynecology/NutritionDuringPregnancy.aspx David A. Ryley, Beth Israel Deaconess Medical Center and Boston IVF, Boston, MA; Meredith Regan, Christine Connolly, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; Doria Harris, Boston IVF, Waltham, MA; Sigal Klipstein, Richard H. Reindollar, Beth Israel Deaconess Medical Center and Boston IVF, Boston, MA. Thu, 05 Nov 2009 15:41:40 GMT http://bidmc.org/Research/Departments/ObstetricsGynecology/GynecologicalOncology.aspx The Division of Gynecologic Oncology has a research program under the direction of Stephen Cannistra, M.D., head of Gynecologic Medical Oncology at Beth Israel Deaconess Medical Center and Professor of Medicine at Harvard Medical School. The program includes a number of ongoing projects, including investigation into the role of microarrays in predicting response to chemotherapy for patients with ovarian cancer, and a number of clinical trials investigating the role of new therapies for such patients. Perhaps most exciting is the study of new biologic therapies for advanced ovarian cancer, such as angiogenesis inhibitors. Many of the clinical trials are open through the collaborative efforts of the institutions comprising the Dana-Farber/Harvard Cancer Center, of which Beth Israel Deaconess is a founding member. The program also maintains a tumor bank for use in basic science investigations in ovarian cancer. Thu, 05 Nov 2009 23:42:41 GMT http://bidmc.org/Research/Departments/OrthopaedicSurgery.aspx The mission of the Orthopedic Biomechanics Laboratory, as part of the Beth Israel Deaconess Medical Center (CareGroup) and Harvard Medical School, is to conduct the highest quality multi-disciplinary scientific research in order to benefit society. The OBL has a commitment to perform professional investigations in the basic and applied research of musculoskeletal biomechanics, while maintaining the Beth Israel Deaconess Medical Center philosophy of respect and compassion for all human and animal life. As a part of this overall mission, the laboratory provides training to students and fellows, who will become the professional researchers and health care professionals of the future. Tue, 05 Aug 2008 20:50:43 GMT http://bidmc.org/Research/Departments/OrthopaedicSurgery/History.aspx History of the Orthopaedic Biomechanics Laboaratory at BIDMC. Tue, 05 Aug 2008 20:50:41 GMT http://bidmc.org/Research/Departments/OrthopaedicSurgery/Personnel.aspx Personnel in the Orthopaedic Biomechanical Laboratory at BIDMC. Mon, 15 Sep 2008 18:09:03 GMT http://bidmc.org/Research/Departments/OrthopaedicSurgery/Research.aspx Research Studies at the Orthopaedic Biomechanical Laboratory. Bone mechanics and modeling Joint kinematics, injury and reconstruction Etiology and prevention of age-related fractures Etiology and prevention of fractures associated with metastatic defects and benign bone defects Biomechanics of fracture healing and treatment Preclinical evaluation of osteodynamic agents Biomechanics of the spine Wed, 10 Jun 2009 16:29:10 GMT http://bidmc.org/Research/Departments/OrthopaedicSurgery/Facilities.aspx Facilities Descriptions at the Orthopaedic Biomechanical Lab at BIDMC. Micro-Computed Tomography (MCT, Mechanical Testing, Bone Densitometry, Joint kinematics, Sports Medicine, Specimen Preparation, Biomaterials/Biochemistry, Computing Machine Shop Tue, 09 Sep 2008 04:01:32 GMT http://bidmc.org/Research/Departments/Pathology.aspx The Division of Experimental Pathology represents the research component of the Department of Pathology at the Beth Israel Deaconess Medical Center. Researchers in the Division of Experimental Pathology have designed in vitro and in vivo models for the characterization of pathological and physiological processes such as aging, asthma, autism, cancer, congenital diaphragmatic hernia, development, diabetes, epilepsy, ventricular arrhythmias, and vascular diseases. They explore the molecular and cellular mechanisms that are involved in tumor progression, angiogenesis, inflammation, and neuronal and cardiac muscle cell physiology. Ongoing studies are elucidating the molecular mechanisms that regulate the survival, migration, invasion, metastasis, and apoptosis of tumor cells, stromal fibroblasts, endothelial cells and immune cells within the tumor microenvironment. The Department of Pathology strongly encourages interactions among research and clinical faculty and provides opportunities to access a human tumor resource through its Divisions of Anatomic Pathology and Laboratory Medicine. With the implementation of a visionary cancer program including a biorepository and robust clinical informatics, the Department of Pathology provides an exceptional environment for scientists to work in a setting that combines the strengthens of Harvard Medical School and its affiliated hospitals with an unusually collegial, supportive and interactive environment. It is our belief that a detailed understanding of the molecular, cellular and physiological events that dictate cellular behavior will lead to novel therapeutic approaches to disease Wed, 18 Mar 2009 15:11:01 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories.aspx Thematically, a core group of investigators based at Research North focus their efforts on the mechanisms of angiogenesis, metastisis, and cancer. Contributions of angiogenic cyotkines, cell adhesion molecules, signal transduction, apoptosis, and cycle cycle control to these processes are being actively investigated. These research efforts also largely form the basis of a Program Project Grant in the Spatial and Temporal Regulation of Angiogenesis primarly centered in our research division. Tue, 28 Apr 2009 17:08:56 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofAlexTokerPh,-d-,D.aspx Alex Toker joined the faculty of Beth Israel Deaconess Medical Center and Harvard Medical School as an Assistant Professor in 2000. In 2003, he was promoted to Associate Professor and joined the faculty of the HMS Ph.D. program in Biological and Biomedical Sciences. Dr. Toker earned his B.A. from King's College, University of London, U.K. in 1987 and his Ph.D. from the National Institute for Medical Research, London. U.K. in 1991 Mon, 02 Nov 2009 19:30:19 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofAndersBerg.aspx Our understanding of the pathophysiology and pathogenic mechanisms of this disease has advanced to a point where the field is ideally poised for translation of these discoveries into clinical solutions for disease prevention and optimal clinical management. Type 2 diabetes mellitus is a disease which develops gradually, starting with a pre-diabetic state characterized by compensated insulin resistance and only mildly elevated blood glucose values, progressing over years to pancreatic islet cell failure, insufficient insulin production, and loss of glucose control Tue, 10 Mar 2009 20:43:43 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofAnnDvorak.aspx We are also evaluating whether the augmented vascular permeability, which has been identified in several types of inflammation, including settings that are characterized by piecemeal degranulation of mast cells or basophils, reflects enhanced formation and/or function of endothelial cell vesiculo-vacuolar organelles (VVOs), rather than transport through classical interendothelial cell gaps such as those that develop in postcapillary venules immediately after the administration of large amounts of histamine Tue, 10 Mar 2009 20:44:12 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofCatherineYan.aspx DNA double stranded breaks (DSBs) are critical lesions that can cause significant alterations in genetic information required for cell survival and proliferation. Aberrant DSB repair can impact on various pathologies, including acceleration of aging and the development of cancer. The broad research focus of the Yan laboratory is to elucidate the fundamental mechanisms that maintain genomic stability in mammalian cells. Mon, 10 Aug 2009 17:44:46 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofDonaldSenger.aspx with the overall goal of identifying new therapeutic strategies for inhibiting and promoting neovascularization. Key aspects of capillary morphogenesis are mimicked by endothelial cells in vitro when they are stimulated by three dimensional collagen I In vitro, and we have identified several signaling pathways and effectors that are activated by collagen I-stimulation which are critical for capillary morphogenesis Tue, 10 Mar 2009 20:45:13 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofHaroldDvorak.aspx The VPF/VEGF family includes VEGF-A and its several isoforms (189, 165 and 121 amino acid variants); VEGF-B; VEGF-C; VEGF-D; and PlGF. To study angiogenesis and lymphangiogenesis, we engineered adenoviral vectors that express these cytokines. These are then injected into various tissues of normal, immunodeficient mice where they induce an angiogenic response Tue, 10 Mar 2009 20:46:14 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofHuiyanZeng.aspx The research in our laboratory has focused on the molecular mechanism of pathological angiogenesis. Pathological angiogenesis is a hallmark of many diseases including ischemic heart disease, wound healing, cancer and inflammation. Vascular endothelial growth factor (VEGF) is one of the most important angiogenesis factors because of its potency and relatively selectivity for vascular endothelium. Tue, 10 Mar 2009 20:46:55 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofIsaacRabinovitz.aspx Another line of study that we are pursuing is the mechanical and mechano-sensory functions of a6b4 and the hemidesmosome. Our recent studies have shown that a6b4 in colon carcinoma cells is involved in the generation of traction and that this function may be important in basement membrane remodeling, which could allow carcinoma cells to clear paths for invasion. Tue, 10 Mar 2009 20:47:26 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofJackLawler.aspx The thrombospondins are extracellular calcium-binding proteins that bind to cell surface receptors including integrins and proteoglycans. Through these interactions, the thrombospondins regulate cellular proliferation, migration, differentiation and apoptosis. Members of the thrombospondin gene family are involved in angiogenesis, tumor progression, wound healing, and bone dysplasias. Wed, 06 May 2009 18:42:21 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofJamesKirby.aspx Bartonella henselae causes cat scratch disease, a prolonged febrile illness associated with lymph node swelling. In AIDS patients, it causes a potentially life threatening angioproliferative disease known as bacillary angiomatosis. Considered an emerging infectious pathogen, Bartonella henselae has an number of unusual properties that make it especially worthy of study. First, it induces angiogenesis or new blood vessel formation. Tue, 10 Mar 2009 20:48:40 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofJeanPierreKinet.aspx Details about Dr. Kinet's research interests may be found at the following link within the Harvard Medical School, Divison of Medical Sciences website. Tue, 10 Mar 2009 20:50:26 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofJeffreyE,-d-,SaffitzMDPhD.aspx Much of our work has focused on the role of gap junction remodeling in arrhythmogenesis in acute and chronic ischemic heart disease. However, we have also characterized the molecular pathology of human cardiomyopathies caused by mutations in genes encoding proteins that form desmosomes. These diseases (Naxos disease, Carvajal syndrome, ARVC Type 8 and plakophilin-related cardiomyopathies) have clinical phenotypes of arrhythmogenic right ventricular cardiomyopathy (ARVC) and/or dilated cardiomyopathy (DCM) associated with a particularly high risk of malignant ventricular arrhythmias and sudden cardiac death (SCD). Wed, 06 May 2009 18:45:13 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofJohnRinn.aspx Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang HY. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.Cell. 2007 Jun 29;129(7):1311-23. Tue, 10 Mar 2009 20:51:59 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofLauraBenjamin.aspx Our research has focused on the study of microvascular development and function. In angiogenesis blood vessels form first by creating an endothelial network for blood flow, which is later remodeled to its final shape and density depending on the metabolic needs of the surrounding tissue. Tue, 10 Mar 2009 21:00:30 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofMatthewAnderson.aspx This is the Long Description. Fusce ut odio vel lectus luctus venenatis. Nulla sagittis faucibus lorem. Sed enim ipsum, ornare eu, semper eget, cursus id, dolor. Curabitur vel leo a turpis pulvinar consequat. Nulla facilisi. Quisque eu felis. Cras fringilla felis at metus. Fri, 28 Nov 2008 17:59:19 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofOlivierKocher.aspx We recently reported the isolation and partial characterization of two novel proteins MAP17 and PDZK1, both markedly upregulated in human carcinomas. PDZK1, isolated as a protein interacting with MAP17, contains four PDZ protein-interactions domains and therefore could potentially interacts with as many as four ligands. Using a combination of yeast two hybrid system and biochemical techniques, we have demonstrated that PDZK1 also interacts with the carboxy-terminal portion of cMOAT (MRP2), the canalicular multispecific organic anion transporter associated with multidrug resistance. Recent studies from other laboratories have confirmed the interactions of PDZK1 with MAP17 and cMOAT Tue, 10 Mar 2009 20:53:28 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofPierPaoloPandolfi.aspx Ma L, Teruya-Feldstein J, Bonner P, Bernardi R, Franz DN, Witte D,Cordon-Cardo C, Pandolfi PP. Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer. Cancer Res. 2007 Aug 1;67(15):7106-12. Tue, 10 Mar 2009 21:03:05 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofRoyaKhosraviFar.aspx crucial aspect of tumorigenesis is the evasion of apoptosis. An understanding of how oncogenes cause resistance to apoptosis will help in the design of more suitable anti-cancer therapies, yet, the mechanisms by which some of the most prominent oncogenes, such as BCR-ABL enable protection from apoptosis are far from clear. Recently, we have observed that BCR-ABL induces evasion of transformed cells from apoptosis by downregulating the transcription of many pro-apoptotic factors Wed, 19 Aug 2009 15:11:01 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofSibelKantarci.aspx Our research focuses on identifying loci and genes for rare genetic disorders in humans. Wed, 26 Nov 2008 17:35:20 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofShuChingShih.aspx It is a sensitive, high-throughput approach to tissue fingerprinting, and offers a systems approach to the discovery of biomarkers and the study of molecular mechanisms. Currently, our transcriptional profiling lab has primer sets for over 800 human and murine genes and we are adding about 50 genes per month. We collaborate with a number of researchers from a variety of institutions in order to more widely share the benefits of our technique and primer library Tue, 10 Mar 2009 20:54:37 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofTristaNorth.aspx Dr. North is an Assistant Professor of Pathology at Harvard Medical School and Beth Israel Deaconess Medical Center. She received a Bachelor’s degree from Bowdoin College in 1996, and her PhD from Dartmouth College in 2002. Her graduate work, in the laboratory of Dr. Nancy Speck, focused on the functional role of Runx1 in hematopoietic stem cell development in the murine embryo. Dr. North conducted her postdoctoral research with Dr. Leonard Zon at Children’s Hospital using zebrafish as a discovery tool for identifying modulators of blood stem cell development. Fri, 15 May 2009 14:32:25 GMT http://bidmc.org/Research/Departments/Pathology/Laboratories/TheLaboratoryofWenyiWei.aspx My previous research demonstrated that APC/cdh1 complex ubiquitinates and thus targets Skp2 for degradation in early G1 phase. This finding provides important insights into why SCF and APC activity is mutually exclusive and how the orchestration of SCF and APC activity affects cell cycle progression. More importantly, it also impinges on the function of Cdh1 as a tumor suppressor. I am also interested in understanding how SCF complexes regulate the G1-S transition by degradation of their specific substrates. Tue, 10 Mar 2009 20:54:59 GMT http://bidmc.org/Research/Departments/Pathology/TraininginAngiogenesisandInflamation.aspx Angiogenesis refers to the generation of new blood vessels from preexisting blood vessels, a process which accompanies a wide variety of pathological states including cancer, wound healing, atherosclerosis and inflammatory disease. Angiogenesis is induced by cytokines and growth factors such as those of the VEGF family, FGF-2, PDGF-B, TGF- b, Ang-1, Ang-2, etc. However, inhibitors such as the thrombospondins are equally important in modulation of this response. Angiogenesis has now become a major field of investigation as many laboratories around the world are attempting to enhance the growth of new blood vessels (as in ischemic heart disease and intermittent claudication) and to prevent vessel growth or even to destroy preexisting vessels that have been induced by cancer. Tue, 10 Mar 2009 19:46:45 GMT http://bidmc.org/Research/Departments/Pathology/TraininginAngiogenesisandInflamation/TrainingGrant.aspx This National Institutes of Health funded training program is based in the Department of Pathology and the Center for Vascular Research at the Beth Israel Deaconess Medical Center. This training program includes two types of appointment. Short-term (3 months) training is offered to undergraduates who are interested in persuing a career in basic sciences or medicine. Whereas these slots are generally filled during the summer, they can be used at anytime during the year. Postdoctoral training is offered in laboratories that focus on angiogenesis and inflammation as well as the closely related field of tumor invasion and metastasis. The scientific focuses and the expertise of the faculty of the training program are described in detail below. These training slots are available for one to three years and are subject to NIH pay back policies. Application to the training program can be made by sending a CV and three letters of reference to Dr. Jack Lawler, Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avevue, E/CLS 503, Boston MA 02215, or by directly contacting a member of the training faculty. The training program encourages application from minority candidates. Tue, 09 Dec 2008 20:20:20 GMT http://bidmc.org/Research/Departments/Psychiatry.aspx As an academic Department of Psychiatry, research and scholarship represent important components of our mission. Clinically oriented research is essential to develop better understanding of the etiology of major psychiatric disorders, and to develop new and more effective approaches to treatment. Wed, 11 Mar 2009 16:40:08 GMT http://bidmc.org/Research/Departments/Psychiatry/CommonwealthResearchCenter.aspx The Commonwealth Research Center (CRC) was created in 1987 at the Massachusetts Mental Health Center (MMHC) by the Massachusetts Department of Mental Health (DMH) to address the need for cutting edge clinical research on schizophrenia and related psychotic disorders. This continued a long-standing tradition of the study of psychosis at MMHC. In 1993, the DMH expanded its commitment to support clinical research by designating two Centers of Excellence. The CRC Mon, 26 Oct 2009 19:01:05 GMT http://bidmc.org/Research/Departments/Psychiatry/CommonwealthResearchCenter/Mission.aspx The Commonwealth Research Center (CRC), based at the Massachusetts Mental Health Center (MMHC) and under the direction of Larry J. Seidman, Ph.D., is a program of the Beth Israel Deaconess Medical Center Department of Psychiatry, Harvard Medical School Department of Psychiatry (HMS) and the Massachusetts Department of Mental Health (DMH). Thu, 15 Oct 2009 13:24:05 GMT http://bidmc.org/Research/Departments/Psychiatry/CommonwealthResearchCenter/NeuropsychologicalDevelopmentduringtheProdrometoPsychosis.aspx Although premorbid neuropsychological (NP) impairments are often cited in support of neurodevelopmental models of schizophrenia and related psychotic illnesses, very little is known about the developmental course of these impairments in relation to psychosis onset. Cross-sectional studies of premorbid and prodromal NP functioning as well as historical prospective and longitudinal cohort and high risk studies suggest a possible progression of impairment immediately preceding or accompanying illness onset Thu, 15 Oct 2009 13:24:05 GMT http://bidmc.org/Research/Departments/Psychiatry/CommonwealthResearchCenter/UnderstandingRewardPathwaysinSchizophrenia.aspx Alcohol and other substance use disorders (A/SUD) are the most common co-occurring condition in patients with schizophrenia, and problems resulting from A/SUD contribute strikingly to the overall severity of schizophrenia. Earlier studies suggest that there may be a link between how patients with schizophrenia experience rewards and A/SUD. Dysfunctional reward circuitry in the brain may itself underlie the use of substances. Thu, 15 Oct 2009 13:24:05 GMT http://bidmc.org/Research/Departments/Psychiatry/CommonwealthResearchCenter/ValidationofIntermediateMeasuresStudy.aspx The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) program is an NIMH initiative supported by a partnership of pharmaceutical companies that was initially developed to The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) program facilitate advancements in pharmacological agents for the treatment of cognitive impairments associated with schizophrenia. The first phase of the MATRICS program, which is now complete, yielded important advances including the selection of a standard cognitive battery for clinical trials of cognitive-enhancing treatments of schizophrenia. Cognitive improvements are obviously necessary, but according to the FDA, not sufficient for drug approval. In addition to changes in cognitive performance, the FDA requires improvements on functionally meaningful measures that have more face validity for consumers and clinicians than cognitive performance measures. Such measures are referred to as intermediate or co-primary measures because they assess capacities that lie between basic cognitive performance and complex community functioning. Regrettably, there is no currently accepted or fully validated co-primary measure. The reason that identifying reliable and valid intermediate measures is important is that changes in complex community functioning are unlikely to be seen in clinical trials of relatively short duration (e.g., less than 1 year). Such long trials are difficult to conduct and hence the development of measures that are associated with cognitive change in shorter term trials is very important. Thu, 15 Oct 2009 13:24:05 GMT http://bidmc.org/Research/Departments/Psychiatry/CommonwealthResearchCenter/AdolescentDevelopmentStudy.aspx This study aims to include adolescents and young adults (13-25 years of age) who are either children or siblings of people with psychotic disorders such as schizophrenia, bipolar disorder, or depression with psychosis, and thus are at “genetic risk” for psychosis on the basis of a family history of psychosis. Thu, 15 Oct 2009 13:24:05 GMT http://bidmc.org/Research/Departments/Psychiatry/CommonwealthResearchCenter/HealthandWellnessResearchProgram.aspx The schizophrenia spectrum disorders, as well as the medications used to treat psychosis, have been associated with multiple adverse health effects. Adverse health effects include increased body mass index (BMI), obesity, altered glucose metabolism, problems with insulin sensitivity and dyslipidemia, and cardiovascular disease. Thu, 15 Oct 2009 13:24:05 GMT http://bidmc.org/Research/Departments/Psychiatry/CommonwealthResearchCenter/PilotStudyofInsightDeficitsandSocialContextinEarlyPsychosis.aspx We are conducting a study to learn more about how individuals in the early phase of a psychotic illness think about the symptoms of their illness and need for psychiatric treatment. The study will explore the way that patients’ beliefs and feelings about having a psychotic illness relate to the perspectives of their family members and to other aspects of patients’ social environment. Thu, 15 Oct 2009 13:24:05 GMT http://bidmc.org/Research/Departments/Psychiatry/CommonwealthResearchCenter/CIDAR.aspx Longitudinal Assessment and Monitoring of Clinical Status and Brain Function in Adolescents and Adults Mon, 19 Oct 2009 21:56:08 GMT http://bidmc.org/Research/Departments/Psychiatry/CommonwealthResearchCenter/FamilyDirectedCognitiveAdaptationResearchStudy.aspx The Family-Directed Cognitive Adaptation Program (FCA) is a treatment research program for patients and families aimed at helping individuals with schizophrenia or schizoaffective disorder improve their independent living skills. Dr. Friedman-Yakoobian has obtained funding through an NIMH T32 Fellowship (The Clinical Research Training Program) and the Peter J. Livingston Fellowship Award to develop this program and to investigate its acceptability and feasibility, and to collect preliminary outcome data. Thu, 15 Oct 2009 13:24:05 GMT http://bidmc.org/Research/Departments/Psychiatry/CommonwealthResearchCenter/Peernetworksandpsychologicalhealthinfirstepisodepsychosis.aspx We are conducting a research study to find out more about the friendships of adolescents and young adults who are currently or have recently been experiencing symptoms of psychosis. The purpose of the study is to learn about the relationship between peer networks and the psychological health and quality of life of these individuals. We also want to find out what factors may influence this relationship, for example, whether certain aspects of friendships are more connected to good psychological health than others. This study involves standard questionnaires, interviews, and tests used routinely by psychologists to measure these characteristics. Thu, 15 Oct 2009 13:24:05 GMT http://bidmc.org/Research/Departments/Psychiatry/CommonwealthResearchCenter/Newsletter.aspx The Commonwealth Research Center (CRC) newsletter is designed to communicate the progress we're making as researchers investigating the underlying causes and optimal treatments for mental illnesses. Our goal is to translate new scientific knowledge to the citizens of Massachusetts. The Communicator will be distributed biannually. Mon, 26 Oct 2009 18:16:41 GMT http://bidmc.org/Research/Departments/Psychiatry/CommonwealthResearchCenter/AnnualReport.aspx The Commonwealth Research Center (CRC) newsletter is designed to communicate the progress we're making as researchers investigating the underlying causes and optimal treatments for mental illnesses. Our goal is to translate new scientific knowledge to the citizens of Massachusetts. The Communicator will be distributed biannually. Wed, 28 Oct 2009 16:46:53 GMT http://bidmc.org/Research/Departments/Psychiatry/CommonwealthResearchCenter/FacultyPublications.aspx Faculty Publications for Commonwealth Research Center Wed, 28 Oct 2009 16:46:53 GMT http://bidmc.org/Research/Departments/Psychiatry/NewEnglandFamilyStudy.aspx The New England Family Study (NEFS) is a longitudinal investigation aimed at identifying obstetric and genetic risk factors for neuropsychiatric and other medical disorders with developmental origins, including schizophrenia, bipolar and major affective disorders, substance use, learning disabilities, attention-deficit/hyperactivity disorder (ADHD) and cardiovascular disease. This historic project is a follow-up study to the National Collaborative Perinatal Project (NCPP), which was conducted during the 1960s in twelve cities throughout the United States. Thu, 17 Jul 2008 13:03:27 GMT http://bidmc.org/Research/Departments/Psychiatry/NewEnglandFamilyStudy/CurrentResearch.aspx The NCPP “children” are now in their late 30s and early 40s. We are conducting a series of adult follow-up studies, in which we locate, recruit, and assess the parents and offspring 30 years after the original assessments ended. In our follow-up efforts, we have successfully located approximately 85% of the selected sample; over 90% of these subjects have participated in interview and laboratory studies, including clinical symptomology, neuropsychological assessment, magnetic resonance imaging, molecular genetics and others. Thu, 17 Jul 2008 13:02:54 GMT http://bidmc.org/Research/Departments/Psychiatry/NewEnglandFamilyStudy/FacultyandStaff.aspx Principal Investigators Stephen L. Buka, Sc.D. Associate Professor, Department of Society, Human Development & Health and Epidemiology, Harvard School of Public Health Jill M. Goldstein, Ph.D. Professor of Psychiatry, Harvard Medical School Larry J. Seidman, Ph.D. Professor of Psychology, Harvard Medical School Ming T. Tsuang, M.D., Ph.D. Director, Harvard Institute of Psychiatric Epidemiology & Genetics, Harvard Departments of Epidemiology and Psychiatry Wed, 22 Oct 2008 15:23:46 GMT http://bidmc.org/Research/Departments/Psychiatry/NewEnglandFamilyStudy/HistoryofProgram.aspx For the past 40 years, investigators at Harvard Medical School, the Harvard School of Public Health and Brown University have conducted and maintained a three-generation longitudinal study of 17,000 persons from the NCPP cohort, followed from before birth through age 40. The NEFS is directed by Dr. Stephen Buka; projects based at MMHC are co-directed by Drs. Jill M. Goldstein, Larry J. Seidman and Ming T. Tsuang. Thu, 17 Jul 2008 13:03:10 GMT http://bidmc.org/Research/Departments/Psychiatry/NewEnglandFamilyStudy/ResearchStudySites.aspx Harvard Medical School , Boston , MA Harvard School of Public Health , Boston , MA Massachusetts Mental Health Center , Boston , MA Nuclear Magnetic Resonance Imaging Center at Massachusetts General Hospital , Charlestown , MA Brown University at Butler Hospital Campus, Providence , RI Brigham and Women's Hospital, Boston , MA Wed, 22 Oct 2008 15:19:27 GMT http://bidmc.org/Research/Departments/Psychiatry/NewEnglandFamilyStudy/SelectedPublications.aspx Buka SL, Lipsitt LP, Tsuang MT. Birth complications and psychological deviancy: A 25-year prospective inquiry. Acta Pediatrica Japonica 1988; 30:537-546. Lipsitt PD, Buka SL, Lipsitt LP. Delinquency risk as a function of early intelligence scores. In King RC, Colliers JK, eds. Social Applications and Issues in Psychology. B.V.: Elsevier Science Publishers 1989; 327-337. Lipsitt PD, Buka SL, Lipsitt LP. Early intelligence scores and subsequent delinquency: A prospective study. American Journal of Family Therapy 1990; 18:192-198. Thu, 17 Jul 2008 20:36:07 GMT http://bidmc.org/Research/Departments/Psychiatry/ProgramforPsychosisRiskAssessmentinYouthandEarlyRemediation.aspx As part of a major new research initiative, Dr. Matcheri Keshavan joined the faculty of the BIDMC Department of Psychiatry in 2008. Dr. Keshavan's work focuses on neurobiological models of schizophrenia and on the development and implementation of early interventions with biopsychosocial treatment strategies. Wed, 14 Jan 2009 14:45:28 GMT http://bidmc.org/Research/Departments/Psychiatry/TheEatingDisorderResearchProgram.aspx The program is directed toward a greater understanding of psychosocial and psychobiological factors contributing to illness onset, symptom perpetuation, recovery, and treatment non-response in patients with bulimia nervosa, anorexia nervosa, binge eating disorder and related disorders. Several investigations focus on the hypothesis that decreased CNS serotonin function contributes to binge eating behaviors and mood dysregulation in some patients with bulimia nervosa and anorexia nervosa. Physiological studies include assessment of pharmacological effects on neuro-endocrine regulation during active illness and following recovery. Thu, 17 Jul 2008 20:36:14 GMT http://bidmc.org/Research/Departments/Psychiatry/TheEatingDisorderResearchProgram/SerotoninStudy.aspx This study is designed to increase our understanding of the process of recovery from the psychiatric disorder called anorexia nervosa. We are specifically interested in learning more about some of the symptoms that follow an episode of anorexia nervosa; these symptoms include feelings of tension, stress and anxiety. This study, funded by the National Institutive of Health, examines the effect of naturally occurring amino acids on serotonin activity in the brain and its potential role in the recovery process from anorexia nervosa. Tue, 17 Feb 2009 18:06:15 GMT http://bidmc.org/Research/Departments/Psychiatry/TransplantInstituteBehavioralHealthResearch.aspx The Transplant Center's Behavioral Health program is internationally recognized for its innovatiove clinical and research programs. This interdisciplinary research program is funded by more than $1.5 million in grants from the National Institutes of Health and the Health Resources and Services Administration of the U.S. Department of Health. Wed, 14 Jan 2009 14:39:28 GMT http://bidmc.org/Research/Departments/Psychiatry/NeurophysiologySleepStudies.aspx The Center for Sleep and Cognition at Beth Israel Deaconess Medical Center, is under the direction of Robert Stickgold, and is devoted to research into the cognitive and emotional functions of sleep. We are interested in how sleep and dreaming participate in the normal processing of emotional experiences and of memories more generally, and how these processes contribute to the mental health of the individual. Current research is focused on the role of sleep in memory consolidation, enhancement, and integration, and the deficits in these processes associated with sleep disorders as well as a range of psychiatric and neurological disorders. Wed, 23 Jul 2008 19:12:36 GMT http://bidmc.org/Research/Departments/Psychiatry/NeurophysiologySleepStudies/ResearchHistory.aspx The Center for Sleep and Cognition (and before that, the Laboratory of Neurophysiology) has been at the forefront of investigations into the role of sleep in learning and memory consolidation. In our published work, we have provided clear demonstrations, and in many cases the first such demonstration. Thu, 17 Jul 2008 20:36:04 GMT http://bidmc.org/Research/Departments/Psychiatry/NeurophysiologySleepStudies/CurrentResearch.aspx Sleep-dependent consolidation of gist memory on a verbal false memory task The role of reward in sleep-dependent consolidation of verbal paired associates memory Sleep-dependent consolidation of memory for related and unrelated word pairs Sleep-dependent enhancement of a probabilistic category-learning task Sleep-dependent consolidation of classical conditioning and its extinction Sleep-dependent consolidation and dreaming of a virtual maze Experimental manipulation of sleep-onset dream content Sleep-dependent memory consolidation in patients with apnea Sleep-dependent memory consolidation in patients with schizophrenia Sleep-dependent memory consolidation in patients with bipolar disorder Postpartum depression and sleep Thu, 17 Jul 2008 13:02:54 GMT http://bidmc.org/Research/Departments/Psychiatry/NeurophysiologySleepStudies/Personnel.aspx Personnel for Neurophysiology Sleep Studies at BIDMC Mon, 15 Sep 2008 18:09:03 GMT http://bidmc.org/Research/Departments/Psychiatry/NeurophysiologyLab.aspx This laboratory uses the techniques of neuronal and system level electrophysiology and neuropharmacology in animal experiments to study the mechanisms of neuronal synchronization and the role of oscillations in normal function of neural networks and their alterations in psychiatric diseases. Fri, 01 Aug 2008 12:38:52 GMT http://bidmc.org/Research/Departments/Psychiatry/NeurophysiologyLab/CurrentProjects.aspx Cortical oscillations in animal models of schizophrenia Contemporary views of schizophrenia regard cognitive dysfunction as the primary core deficit due to dysfunction of neuronal microcircuits. Brain oscillations are known to be critical for cognitive processes and their alterations in schizophrenic patients were proposed to significantly contribute to the neurocognitive impairments characteristic for this disease. This project examines the functioning of neuronal networks involved in cortical oscillations in neurodevelopmental animal models of schizophrenia in an attempt of finding a link between the structural changes and neurocognitive deficits. This work will increase our neuronal level understanding of the mechanisms of cognitive deficits in schizophrenia which will facilitate the development of new strategies for drug development. Fri, 01 Aug 2008 12:38:50 GMT http://bidmc.org/Research/Departments/Psychiatry/NeurophysiologyLab/Faculty.aspx Neurophysiology Lab faculty at BIDMC in the Department of Psychiatry. Mon, 15 Sep 2008 16:06:39 GMT http://bidmc.org/Research/Departments/Psychiatry/NeurophysiologyLab/Publications.aspx Publications featuring memebers of the Neurophysiology Lab at BIDMC Fri, 08 Aug 2008 18:30:46 GMT http://bidmc.org/Research/Departments/Radiology.aspx Radiology Research at BIDMC. Mon, 15 Sep 2008 18:00:12 GMT http://bidmc.org/Research/Departments/Radiology/MRI.aspx MR Research at Beth Israel Deaconess Medical Center Thu, 06 Nov 2008 21:28:23 GMT http://bidmc.org/Research/Departments/Radiology/MRI/AboutUs.aspx MRI Research at Beth Israel Deaconess Medical Center: About Us Wed, 24 Jun 2009 13:01:17 GMT http://bidmc.org/Research/Departments/Radiology/MRI/Facilities.aspx MRI Research Facilities at Beth Israel Deaconess Medical Center Wed, 24 Jun 2009 13:01:17 GMT http://bidmc.org/Research/Departments/Radiology/MRI/Faculty.aspx Research Faculty in MRI at BIDMC Thu, 23 Jul 2009 19:48:33 GMT http://bidmc.org/Research/Departments/Radiology/MRI/Presentations.aspx Presentations in MRI Wed, 24 Jun 2009 13:01:19 GMT http://bidmc.org/Research/Departments/Radiology/MRI/UserInformation.aspx User Information, MRI Research Center at the Beth Israel Deaconess Medical Center Wed, 24 Jun 2009 13:15:32 GMT http://bidmc.org/Research/Departments/Radiology/MRI/Brochure.aspx Printable Brochure, MR Research at Beth Israel Deaconess Medical Center Wed, 24 Jun 2009 13:01:20 GMT http://bidmc.org/Research/Departments/Radiology/InterventionalRadiology.aspx Through improved technology of catheter-based interventions, it is possible to treat many diseases which until now have required full surgical procedures. We are developing techniques for nonsurgical treatment of a variety of disorders. These include: Nonpharmacologic Analgesia for Invasive Procedures Nonsurgical treatment of blockage of arteries or veins using balloon angioplasty Atherectomy and stent placement Nonsurgical treatment of abdominal aortic aneurysm Treatment of strokes with the drug urokinase Nonsurgical treatment of male infertility by embolization of the testicular vein for varicocele Nonsurgical treatment of female infertility by opening of blocked fallopian tubes Nonsurgical treatment of gastrointestinal bleeding by embolization Embolization of cancers to decrease their blood supply Nonsurgical portacaval shunts for esophageal varices or ascites secondary to liver cirrhosis Self-hypnotic Relaxation for Large Core Breast Biopsy Tue, 16 Sep 2008 14:01:29 GMT http://bidmc.org/Research/Departments/Radiology/NeuroRSNA.aspx RSNA 2008 Mon, 13 Oct 2008 13:07:59 GMT http://bidmc.org/Research/Departments/Radiology/CenterforBasicMRResearch.aspx The Center for Basic Magnetic Resonance Research at the Beth Israel Deaconess Medical Center provides facilities for nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) for cell culture, perfused organ, excised sample, and invio small animal studies. Fri, 12 Sep 2008 17:44:29 GMT http://bidmc.org/Research/Departments/Radiology/CenterforBasicMRResearch/Faculty.aspx Center for Basic MR Research Faculty at BIDMC. Fri, 25 Jul 2008 20:45:00 GMT http://bidmc.org/Research/Departments/Radiology/CenterforBasicMRResearch/Facilities.aspx The BIDMC Center for Basic MR Research provides facilities for NMR spectroscopy and MRI studies of cell culture, perfused organ, excised tissue, and in vivo small animal protocols. Fri, 25 Jul 2008 20:45:00 GMT http://bidmc.org/Research/Departments/Radiology/CenterforBasicMRResearch/Applications.aspx The Center for Basic MR Research will run routine MR spectroscopy or imaging experiments on an hourly fee basis. Faculty members of the facility are available to discuss feasibility of a given protocol.Standard applications of the lab include anatomic, T1, T2, diffusion, and perfusion studies. In addition, global and localized spectroscopy experiments are available for either proton or multinuclear applications. Cultured tissue, excised organ, and in vivo model systems are utilized in the following ongoing studies: Fri, 25 Jul 2008 20:44:58 GMT http://bidmc.org/Research/Departments/Radiology/NMDownload.aspx PET-CT Viewer & Nuclear Medicine Mini-PACS Download Tue, 23 Sep 2008 19:11:19 GMT http://bidmc.org/Research/Departments/Radiology/Ultrasound.aspx Current projects in obstetric ultrasound include evaluation of intrauterine growth retardation, evaluation of the abnormal first trimester pregnancy, and multiple projects regarding use of magnetic resonance imaging (MRI) in obstetrics. Thu, 18 Sep 2008 15:19:27 GMT http://bidmc.org/Research/Departments/Radiology/Ultrasound/Aneuploidy.aspx The guidelines in these pages provide additional information about commonly misunderstood ultrasound findings of fetal aneuploidy and serve to standardize information provided by radiologists to obstetric providers. Mon, 25 Aug 2008 20:45:08 GMT http://bidmc.org/Research/Departments/Radiology/Ultrasound/Atlas.aspx Compendium of Fetal MRI Thu, 09 Oct 2008 19:10:39 GMT http://bidmc.org/Research/Departments/Radiology/Ultrasound/Fetal.aspx Magnetic resonance (MR) imaging is a valuable complement to ultrasound when additional information is needed to make treatment decisions during pregnancy. In the past studies were limited by fetal motion. Due to fast imaging techniques now available, images can be obtained in less than 1/2 a second. This means that neither the mother nor the fetus needs to be sedated. Mon, 22 Sep 2008 14:29:22 GMT http://bidmc.org/Research/Departments/Radiology/Ultrasound/UltrasoundPublications.aspx Beth Israel Deaconess Medical Center:Ultrasound Publications Thu, 25 Sep 2008 16:28:28 GMT http://bidmc.org/Research/Departments/Radiology/Laboratories.aspx Centers & Laboratories in MR Research at Beth Israel Deaconess Medical Center Sat, 27 Sep 2008 14:33:17 GMT http://bidmc.org/Research/Departments/Radiology/Laboratories/BasicMR.aspx Center for Basic MR Research at the Beth Israel Deaconess Medical Center Sat, 27 Sep 2008 14:30:11 GMT http://bidmc.org/Research/Departments/Radiology/Laboratories/Cartilage.aspx Nondestructive techniques for acurately assessing the structural and functional integrity of cartilage are essential for defining the natural history of arthritis and for evaluating the effects of prevention and therapeutic interventions. The long-term goal of the functional cartilage imaging group is to establish magnetic resonance imaging (MRI) techniques for evaluating the compositional and functional integrity of articular cartilage. Sat, 27 Sep 2008 14:30:12 GMT http://bidmc.org/Research/Departments/Radiology/Laboratories/FrangioniLab.aspx Our mission is to solve important clinical problems by applying first principles from chemistry and engineering. The major focus of the laboratory is on the development of imaging technology and contrast agents to see cancer at its smallest possible manifestation. We believe that "Seeing is Curing" that is, if we can see cancer at an earlier stage than we now can (currently about 1 billion cells) we will have a greater likelihood of curing it. Thu, 11 Sep 2008 15:06:42 GMT http://bidmc.org/Research/Departments/Radiology/Laboratories/Optical.aspx In Vivo Optical Imaging Laboratory at Beth Israel Deaconess Medical Center Sat, 27 Sep 2008 14:30:12 GMT http://bidmc.org/Research/Departments/Radiology/ClinicalTrials.aspx Clinical Trials in Radiology Tue, 16 Sep 2008 14:00:35 GMT http://bidmc.org/Research/Departments/Radiology/ClinicalTrials/Tracheomalacia.aspx CT Diagnosis of Tracheomalacia in COPD Clinical Trial Wed, 17 Sep 2008 16:08:49 GMT http://bidmc.org/Research/Departments/Radiology/ClinicalTrials/RCTOServices.aspx Radiology Clinical Trials Office Services Sat, 04 Oct 2008 14:24:23 GMT http://bidmc.org/Research/Departments/Radiology/ClinicalTrials/RCTOTrials.aspx Radiology Clinical Trials Office List of Trials Wed, 03 Sep 2008 17:02:16 GMT http://bidmc.org/Research/Departments/Radiology/ResearchFaculty.aspx Research Faculty in the Department of Radiology at BIDMC Mon, 31 Aug 2009 12:37:41 GMT http://bidmc.org/Research/Departments/SpineCenter.aspx This is the Long Description. Fusce ut odio vel lectus luctus venenatis. Nulla sagittis faucibus lorem. Sed enim ipsum, ornare eu, semper eget, cursus id, dolor. Curabitur vel leo a turpis pulvinar consequat. Nulla facilisi. Quisque eu felis. Cras fringilla felis at metus. Tue, 26 May 2009 16:41:40 GMT http://bidmc.org/Research/Departments/Surgery.aspx The Beth Israel Deaconess Medical Center, a flagship teaching hospital of Harvard Medical School, is known for its exemplary patient care, conducting leading-edge clinical and basic science research, and supporting outstanding educational programs. Within the Roberta and Stephen R. Weiner Department of Surgery, the surgical residencies are the heart of the Department. We provide a well-structured clinical curriculum supervised by an outstanding faculty. In addition, we have created a multitude of opportunities for experience and training in basic research, both in the medical center and in the Medical School quadrangle. Thu, 24 Jul 2008 20:11:00 GMT http://bidmc.org/Research/Departments/Surgery/CardiacSurgery.aspx BIDMC cardiac surgery research is among the top-funded programs of its kind by the National Institutes of Health, with one of only a few NIH-funded training grants for cardiovascular surgery research. A sample of current research: Active Clinical Research Programs Genomic and proteomic changes during cardiac surgery. Relevance to neurocognitive outcome. (Frank Sellke, M.D.) Poly (ADP-ribose) polymerase inhibition during cardiac surgery (Frank Sellke, M.D.) Emerging valve technologies, including St. Jude Medical’s Epic biologic valve (All surgeons) Total artificial heart Thu, 23 Jul 2009 17:33:26 GMT http://bidmc.org/Research/Departments/Surgery/CardiacSurgery/ONX.aspx Clinical Trial of the On-X® Valve Using Low Dose Anticoagulation *The purpose of this study is to define the lowest level of required antithrombotic (anti-blood clot) drug therapy after receiving the On-X heart valve. The On-X heart valve is approved by the Food and Drug Administration (FDA) and is intended for treatment of patients who have been diagnosed with a diseased heart valve, and require replacement of their natural aortic or mitral valve, or previously implanted mechanical or tissue aortic or mitral valve. The study treatment will be similar to that provided to patients who have their heart valves replaced with any other commercially available prosthetic heart valve. This study is a randomized trial of three different antithrombotic drug therapies. Thu, 04 Dec 2008 19:54:22 GMT http://bidmc.org/Research/Departments/Surgery/CardiacSurgery/RabbitcDNA.aspx Rabbit heart cDNA libraries were constructed to allow for investigation of the molecular mechanisms of cardioprotection. CDNAs, rather than oligomers, were used to allow for greater specificity. The rabbit heart model is an established research model with the advantage of being a close evolutionary reference species to humans. The use of the rabbit heart in cardiovascular research allows for investigation in a model which lacks xanthine oxidase. The rabbit heart also serves as a model similar in myosin heavy chain composition to the human as well as similar hemodynamic and homeostatic properties to the human. Mon, 20 Jul 2009 20:15:12 GMT http://bidmc.org/Research/Departments/Surgery/CenterforMinimallyInvasiveSurgery.aspx The Center for Minimally Invasive Surgery at Beth Israel Deaconess Medical Center will engage in wide-ranging research to help advance the evolving field of laparoscopic surgery and continue to improve patient care. Thu, 24 Jul 2008 00:57:14 GMT http://bidmc.org/Research/Departments/Surgery/CenterfortheStudyofNutritionMedicine.aspx The Center for the Study of Nutrition Medicine (CSNM) has 30-years of extensive experience conducting longitudinal studies particularly in multicenter settings. We are well equipped with the infrastructure to develop clinical investigation and outcomes assessment. CSNM provides sophisticated, scientific nutrition interventions that are utilized to support research, training and patient care. The CSNM mission is in line with the medical center's “bench-to-bedside” mission. We are constantly striving to address today’s health challenges in nutrition medicine with innovative strategies. Wed, 22 Jul 2009 15:47:25 GMT http://bidmc.org/Research/Departments/Surgery/CenterfortheStudyofNutritionMedicine/AboutUs.aspx The name and title of the staff at the Center for the Study of Nutrition Medicine at BIDMC. Wed, 22 Jul 2009 15:31:41 GMT http://bidmc.org/Research/Departments/Surgery/CenterfortheStudyofNutritionMedicine/Courses.aspx Course offerings organized by the CSNM and friends of the CSNM Wed, 22 Jul 2009 16:02:50 GMT http://bidmc.org/Research/Departments/Surgery/CenterfortheStudyofNutritionMedicine/Research.aspx A description of the research projects and topics at the CSNM Wed, 22 Jul 2009 15:46:06 GMT http://bidmc.org/Research/Departments/Surgery/CenterfortheStudyofNutritionMedicine/Blog.aspx Link to blog by Kristina about Healthy Living Wed, 04 Feb 2009 19:58:33 GMT http://bidmc.org/Research/Departments/Surgery/CenterfortheStudyofNutritionMedicine/HealthyLiving.aspx This is the Long Description for the harvard center for healthy living. Wed, 22 Jul 2009 16:25:25 GMT http://bidmc.org/Research/Departments/Surgery/CenterfortheStudyofNutritionMedicine/CSNMEventsPage.aspx Important Events for the CSNM at BIDMC Thu, 05 Feb 2009 19:26:56 GMT http://bidmc.org/Research/Departments/Surgery/DepartmentofSurgeryAnnualReports.aspx This is where the Department of Surgery Annual Research Reports will be housed each year. Wed, 17 Jun 2009 17:27:49 GMT http://bidmc.org/Research/Departments/Surgery/Faculty.aspx Dr. Wu has re-established his brain tumor research laboratory at the Beth Israel Deaconess Medical Center, where he continues his research on gene therapy and molecular genetics of brain tumors. He has collaborations with research laboratories in Boston and New York. These collaborations have furthered our understanding and treatment of brain tumors. Dr. Dubuisson continues his intraoperative micro-electrode, neurophysiologic research into functional neurosurgery with Rami Burstein, Ph.D., at the Harvard Institute of Medicine. Dr. Weller plans to continue his prior research, which focused on neuronal regeneration and cellular neuroprotection following spinal cord injury. Thu, 24 Jul 2008 00:57:54 GMT http://bidmc.org/Research/Departments/Surgery/PlasticandReconstructiveSurgery.aspx Current research in the Division of Plastic and Reconstructive Surgery consists of both basic science and clinical research. Major areas include: breast reconstructive surgery, hand-microsurgery, head & neck reconstruction, and perforator, 3-D, and functional MRI imaging. Fri, 25 Sep 2009 13:39:50 GMT http://bidmc.org/Research/Departments/Surgery/UrologicSurgery.aspx Urologic Surgery Research at BIDMC Mon, 15 Dec 2008 16:36:17 GMT http://bidmc.org/Research/Departments/Surgery/UrologicSurgery/CenterforMinimallyInvasiveUrologicSurgeryResearch.aspx This is the Long Description. Fusce ut odio vel lectus luctus venenatis. Nulla sagittis faucibus lorem. Sed enim ipsum, ornare eu, semper eget, cursus id, dolor. Curabitur vel leo a turpis pulvinar consequat. Nulla facilisi. Quisque eu felis. Cras fringilla felis at metus. Tue, 04 Nov 2008 21:32:55 GMT http://bidmc.org/Research/Departments/Surgery/UrologicSurgery/DasResearch.aspx This is the Long Description. Fusce ut odio vel lectus luctus venenatis. Nulla sagittis faucibus lorem. Sed enim ipsum, ornare eu, semper eget, cursus id, dolor. Curabitur vel leo a turpis pulvinar consequat. Nulla facilisi. Quisque eu felis. Cras fringilla felis at metus. Tue, 04 Nov 2008 21:27:40 GMT http://bidmc.org/Research/Departments/Surgery/UrologicSurgery/DeWolfLaboratory.aspx Basic research: My major interests include understanding the effects of bladder outlet obstruction on bladder function and elucidating the mechanisms of sacral neuromodulation for refractory voiding dysfunction. I have been working with rabbit and rat models of bladder outlet obstruction to determine the effects of short and long term obstruction on various parameters determining detrusor function. We have also combined an outlet obstruction model in rabbits with sacral neuromodulation to study the effects of sacral neuromodulation on the decompensated detrusor. Tue, 04 Nov 2008 21:27:40 GMT http://bidmc.org/Research/Departments/Surgery/VascularSurgery.aspx Clinical Research: The Division is supported by a very active clinical research program including: Outcome studies of arterial reconstructive surgery, including the ultimate well-being and independence of patients, prevention of amputation and stroke, the risks and benefits of all procedures. Wed, 18 Nov 2009 20:18:58 GMT http://bidmc.org/Research/Departments/Surgery/VascularSurgery/CHOICE.aspx This study is to collect data about patients’ medical experiences and conditions following treatment of carotid stenosis. Tue, 06 Jan 2009 19:01:42 GMT http://bidmc.org/Research/Departments/Surgery/VascularSurgery/EMPiRE.aspx The GORE Neuro Protection System (NPS) (the “Study Device”) is a protection device that is designed to protect your brain from particles (emboli) that may break off when the narrowing or blockage (stenosis) is cleared. Tue, 06 Jan 2009 19:04:00 GMT http://bidmc.org/Research/Departments/Surgery/VascularSurgery/SAPPHIRE.aspx This study is being done to collect data regarding patients’ medical experiences and conditions following treatment with the PRECISE® Nitinol Stent Systems and the ANGIOGUARD™ XP/RX Emboli Capture Guidewire Tue, 06 Jan 2009 19:05:29 GMT http://bidmc.org/Research/Departments/Surgery/VascularSurgery/TAG.aspx The main purpose of this study is to collect data about the long-term performance of the GORE TAG Thoracic Endoprosthesis through 5 years when used as the primary treatment of descending thoracic aneurysms. Tue, 06 Jan 2009 19:07:31 GMT http://bidmc.org/Research/Departments/Surgery/SurgicalResidentFundingSources.aspx Surgical Resident Funding Sources in Research at BIDMC Mon, 23 Mar 2009 19:04:55 GMT http://bidmc.org/Research/Departments/TransplantInstitute.aspx Beth Israel Deaconess Medical Center is renowned for its achievements in medical research, including breakthroughs in the area of transplant immunology (the body’s ability to accept or reject foreign tissue). Grants from private foundations and government agencies support clinical and biomedical research. Among independent hospitals nationwide, BIDMC ranks third in National Institutes of Health funding. Wed, 18 Nov 2009 20:18:57 GMT http://bidmc.org/Research/Departments/TransplantInstitute/TransplantResearchCenter.aspx BIDMC’s Transplant Research Center and its principal investigators in the departments of surgery and medicine have national and international reputations for excellence and innovation. The center attracts students, fellows and post-doctoral individuals from around the world. In total, there are over 70 investigators in the Transplant Research Center, which is funded by more than $11 million in grants. Investigators engaged in bench research study the chemical and molecular make-up of cells and tissues for clues about organ rejection and tolerance. Their discoveries become the foundation for clinical research here and around the world. Mon, 23 Mar 2009 02:38:32 GMT http://bidmc.org/Research/Departments/TransplantInstitute/AboutClinicalTrialsattheTransplantInstitute.aspx BIDMC investigators in the Transplant Research Center help “translate” their laboratory discoveries into clinical trials that eventually lead to improved treatments that benefit patients here and elsewhere. Clinical trials are research studies that evaluate new procedures or drugs, weighing their effectiveness against current, standard protocols. Mon, 23 Mar 2009 02:38:06 GMT http://bidmc.org/Research/Departments/TransplantInstitute/AboutClinicalTrialsattheTransplantInstitute/GuidetoClinicalTrialsattheTransplantInstitute.aspx BIDMC investigators in the Transplant Research Center help “translate” their laboratory discoveries into clinical trials that eventually lead to improved treatments that benefit patients here and elsewhere. Clinical trials are research studies that evaluate new procedures or drugs, weighing their effectiveness against current, standard protocols. Mon, 23 Mar 2009 02:38:17 GMT http://bidmc.org/Research/Departments/TransplantInstitute/AboutClinicalTrialsattheTransplantInstitute/SummaryofTrialsforPatientsPriortoTransplant.aspx Summary of Trials for Patients Prior to Transplant Tue, 24 Mar 2009 14:31:34 GMT http://bidmc.org/Research/Departments/TransplantInstitute/AboutClinicalTrialsattheTransplantInstitute/SummaryofTrialsforPatientsattheTimeofTransplant.aspx Summary of Trials for Patients at the Time of Transplant Wed, 24 Sep 2008 19:56:10 GMT http://bidmc.org/Research/Departments/TransplantInstitute/AboutClinicalTrialsattheTransplantInstitute/SummaryofTrialsforPatientsAfterTransplant.aspx Summary of Trials for Patients After Transplant Wed, 24 Sep 2008 19:56:10 GMT http://bidmc.org/Research/Departments/TransplantInstitute/BehavioralHealthResearch.aspx The Transplant Institute’s Behavioral Health program is internationally recognized for its innovative clinical and research programs. This interdisciplinary research program is funded by more than $1.5 million in grants from the National Institutes of Health and the Health Resources and Services Administration of the U.S. Department of Health. Tue, 24 Mar 2009 14:07:08 GMT http://bidmc.org/Research/Departments/TransplantInstitute/OtherImportantResearchInitiatives.aspx Separate from clinical trails are the research study protocols that distinguished members of the transplant team conduct. These studies are many and varied, ranging from identifying the best measures of kidney function for transplant patients and living donors, to defining predictors of successful transplant outcomes. Patients who are willing and who qualify for enrollment help to further the larger body of knowledge pertaining to the science and treatment of transplantation. Tue, 24 Mar 2009 14:27:22 GMT http://bidmc.org/Research/Departments/TransplantInstitute/OurTransplantResearchCenterTeam.aspx The Transplant Center has an entire team of researchers - transplant immunologists - who are working on research breakthroughs to continually enhance patient care. The Transplant Research Center, directed by Terry B. Strom, MD, has an international reputation for excellence and clinical and laboratory innovation. Research interests are broad and include basic and applied immunobiology, tolerance, xenotransplantation, molecular diagnostics, liver regeneration, vascular biology, bioinformatics and the role of protective genes in transplantation. Tue, 24 Mar 2009 14:27:28 GMT http://bidmc.org/Research/ClinicalResearch.aspx Clinical research is the study of human physiology in health and disease. It refers to investigations done on humans and includes the scientific study of how a new medicine or treatment works in people. Clinical research may be conducted to better understand how the body stays healthy, what causes it to become ill, or how it heals or adapts in spite of illness. Clinical research studies include human healthy volunteers as well as patients in an effort to answer specific scientific questions. Thu, 12 Feb 2009 16:41:26 GMT http://bidmc.org/Research/ClinicalResearch/ClinicalTrialsatBIDMC.aspx Information on Conducting Clinical Trials at BIDMC Sun, 31 May 2009 23:53:20 GMT http://bidmc.org/Research/ClinicalResearch/ResourcesForParticipants.aspx Information for Participants and Families Fri, 13 Feb 2009 15:19:05 GMT http://bidmc.org/Research/ClinicalResearch/CareersandTraining.aspx Careers Mon, 01 Jun 2009 00:01:53 GMT http://bidmc.org/Research/ClinicalTrials.aspx As you consider treatment options for yourself or a loved one, you may be considering participation in a clinical trial. What is a clinical trial? Why do people participate in these studies? The information and links below will provide you with more information about clinical trials: what they are, how they work, and other resources that may be available to you. Mon, 23 Feb 2009 16:15:37 GMT http://bidmc.org/Research/CoreFacilities.aspx Research Facilities provides space and facilities management support to the Researchers and Research Administrators supporting the research mission at BIDMC. This newly reorganized group includes personnel to help with lab moves, research equipment inventory, space management and reporting, research facilities infrastructure support and strategic planning Fri, 09 Oct 2009 17:43:43 GMT http://bidmc.org/Research/CoreFacilities/BiomedicalResearchInformaticsCore.aspx The mission of the Biomedical Research Informatics Core (BRIC) is to utilize the expertise of BIDMC "informaticians" with backgrounds in medicine, biology, engineering, biostatistics, and computer science to facilitate research at our institution by (a) providing a high level of service and experience in informatics that is difficult for individual laboratories to achieve and maintain, (b) developing the infrastructure required to address common informatics needs of all researchers, and (c) identifying areas in which there can be closer collaboration among life scientists and quantitative scientists. Thu, 07 May 2009 17:33:56 GMT http://bidmc.org/Research/CoreFacilities/BerensonAllenCenterforNoninvasiveBrainStimulation.aspx The Laboratory for Magnetic Brain Stimulation provides a cutting edge methodology for assessing the function of the cerebral cortex and motor systems. The method of repetitive cortical magnetic stimulation was pioneered by Dr. Pascual-Leone, the Director of the Laboratory, and is currently finding uses in a variety of clinical situations, ranging from depression and movement disorders to neurorehabilitation. Thu, 14 May 2009 18:14:34 GMT http://bidmc.org/Research/CoreFacilities/CardiacPhysiologyCore.aspx Cardiovascular pathology is a common and an important finding in animal studies, especially in genetically altered animals. It is also closely associated with endocrine abnormalities, pulmonary pathology, vascular pathology, etc. The goal of Cardiac Physiology Core is to provide expertise in evaluation of cardiac pathology for non-cardiovascular and cardiovascular researchers who are not equipped for such analysis. We provide non-invasive and invasive evaluation of cardiac physiology that may be difficult or time-consuming for those investigators without proper expertise, experience and equipments. Thu, 07 May 2009 17:33:56 GMT http://bidmc.org/Research/CoreFacilities/DNASequencingCore.aspx The BIDMC DNA Sequencing Facility, equipped with an ABI Prism 377XL Automated DNA Sequencer, has been operating for several years now. Approximately 96 samples per day are processed. Average turn around time is 2 business days (subject to change if demand increases). Priority lanes are also available for faster results. A typical run will yield >98% accuracy from base 5-600, plus another 100 bases of less accurate sequence. Always check your chromatogram, especially if designing primers. Thu, 30 Jul 2009 17:40:53 GMT http://bidmc.org/Research/CoreFacilities/DNASequencingCore/SubmissionProcedure.aspx Getting started at the DNA Sequencing Core at BIDMC. Mon, 16 Feb 2009 19:40:20 GMT http://bidmc.org/Research/CoreFacilities/eDataCollectionCore.aspx The Research Electronic Data Collection Core can help you capture research data by supporting all aspects of data acquisition, storage and retrieval. The core is designed to significantly improve the efficiency, cost structure and overall quality of research data collection. Mon, 06 Jul 2009 19:08:13 GMT http://bidmc.org/Research/CoreFacilities/FlowCytometryCore.aspx The Flow Cytometry core facility is committed to meet all of the flow cytometry needs for the BIDMC and the external research community. The facility offers state of the art instrumentation for routine flow cytometry and cell sorting. The Facility is continuously expanding with the newest software and machinery for both sort and analysis capabilities of up to 18 flourescent parameters. Thu, 07 May 2009 18:57:52 GMT http://bidmc.org/Research/CoreFacilities/FlowCytometryCore/GettingStarted.aspx Flow Cytometry Core at Beth Israel Deaconess Medical Center. Thu, 07 May 2009 20:03:12 GMT http://bidmc.org/Research/CoreFacilities/FlowCytometryCore/PoliciesandProcedures.aspx Flow Cytometry Core Policies and Procedures Thu, 26 Feb 2009 17:13:24 GMT http://bidmc.org/Research/CoreFacilities/FlowCytometryCore/FacilitiesandEquipment.aspx Flow Cytometry Facilities and Equipment Thu, 26 Feb 2009 17:12:57 GMT http://bidmc.org/Research/CoreFacilities/FlowCytometryCore/RelatedLinks.aspx Flow Cytometry Related Links Thu, 26 Feb 2009 17:22:47 GMT http://bidmc.org/Research/CoreFacilities/GenomicsProteomicsCore.aspx The BIDMC Genomics Center provides all of the tools of modern functional genomics and proteomics, for academic and corporate clients alike. The enter is equipped with State-of-the-Art technologies for transcriptional profiling, genotyping, proteomics, real-time PCR and robotics. Thu, 07 May 2009 17:34:03 GMT http://bidmc.org/Research/CoreFacilities/HistologyCore.aspx To provide services in paraffin histology for cells and tissues including embedding, sectioning, and routine staining to investigators at Beth Israel Deaconess Medical Center (BIDMC). Work is done on a fee-for-service basis. Priority use is given to BIDMC investigators, but outside users are accepted. Mon, 06 Jul 2009 19:05:13 GMT http://bidmc.org/Research/CoreFacilities/HistologyCore/Services.aspx The Histology Core Facility provides routine paraffin services including processing, embedding, sectioning, frozen, sectioning, and staining. Thu, 07 May 2009 22:06:47 GMT http://bidmc.org/Research/CoreFacilities/HistologyCore/Fees.aspx Histology Service Price Listing Thu, 07 May 2009 22:06:47 GMT http://bidmc.org/Research/CoreFacilities/HistologyCore/GettingStarted.aspx When submitting tissues to the Histology Core Facility for processing, please mark all containers clearly, so that the labels are easy to read. Alternatively, tissues can be submitted in cassettes, which can be purchased from Fischer (Histosette Biopsy Cassettes, cat. #15182702A). If you would, please label all cassettes with a #2 pencil. The Histology Core Facility is not responsible for labels lost to processing and will not be expected to re-label cassettes submitted in pen. Labels written with most commercial markers (including solvent resistant pens and Sharpie) will dissolve due to the prolonged exposure to xylene and fixative during processing. Fri, 08 May 2009 17:24:13 GMT http://bidmc.org/Research/CoreFacilities/HistologyCore/RelatedLinks.aspx Histology Core Links Thu, 07 May 2009 22:06:47 GMT http://bidmc.org/Research/CoreFacilities/HistologyCore/Location.aspx Histology Core Location Thu, 30 Jul 2009 17:41:48 GMT http://bidmc.org/Research/CoreFacilities/HistologyCore/ContactUs.aspx Histology Core Contacts Fri, 08 May 2009 13:42:28 GMT http://bidmc.org/Research/CoreFacilities/ImagingMicroscopyCore.aspx The Microscopy Core Facility at the Beth Israel Deaconess Medical Center (BIDMC) has 2 active microscopy services. First, the Electron Microscopy Core provides service, technical assistance, and instrumentation for electron microscopy techniques. Second, the Confocal Microscopy Service provides service and technical assistance for immunostaining, conventional and live-cell confocal microscopy, light (photodocumentation) and fluorescence microscopy, digital image acquisition and processing, and digital and conventional darkroom printing. Thu, 07 May 2009 17:34:08 GMT http://bidmc.org/Research/CoreFacilities/MassSpectrometryCore.aspx The Mass Spectrometry Core Facility has been serving the BIDMC community since 2004. We specialize in a targeted mass spectrometry based proteomics approach for isolated proteins and protein complexes, especially phosphorylation and other post-translational modifications involved in cellular signaling using cutting edge instrumentation. Thu, 07 May 2009 18:58:32 GMT http://bidmc.org/Research/CoreFacilities/RealTimePCRCore.aspx To perform Real-Time-PCR and provide quantitative data on levels of gene expression. The Core comprises an ABI 7700 Sequence Detector System, equipped with all an investigator needs for experimental design/run and data processing. Thu, 07 May 2009 17:34:09 GMT http://bidmc.org/Research/CoreFacilities/SmallAnimalImagingCore.aspx Our goal is to provide state-of-the-art small animal imaging services to researchers in the Longwood Medical Area of Harvard Medical School. These services include multi-modality imaging, advanced data analysis, image fusion resources, and a satellite animal facility for longitudinal studies. A detailed description of our instruments and services are provided on this website, and we welcome questions and comments. Thu, 07 May 2009 17:34:09 GMT http://bidmc.org/Research/CoreFacilities/TransgenicCore.aspx The Basic Services of the Beth Israel Deaconess Transgenic Facility are: Embryonic Stem Cell Injections Embryo Freezing Line Rescue Somatic Cell Injections Thu, 07 May 2009 17:34:09 GMT http://bidmc.org/Research/CoreFacilities/XrayCrystallographyCore.aspx The X-ray Crystallography Facility was recently established as a core to serve the needs of investigators in the BIDMC and Harvard Medical School community interested in using structural biology as a tool in their research. Thu, 29 Oct 2009 19:06:46 GMT http://bidmc.org/Research/ResearchCenters.aspx In 2003, BIDMC's Research Strategic Plan called for the creation of a number of interdisciplinary "centers" to promote the collaboration among investigators in departments and specialties throughout the medical center. Mon, 16 Feb 2009 18:16:09 GMT http://bidmc.org/Research/ResearchCenters/BerensonAllenCenterforNoninvasiveBrainStimulation.aspx The Laboratory for Magnetic Brain Stimulation provides a cutting edge methodology for assessing the function of the cerebral cortex and motor systems. The method of repetitive cortical magnetic stimulation was pioneered by Dr. Pascual-Leone, the Director of the Laboratory, and is currently finding uses in a variety of clinical situations, ranging from depression and movement disorders to neurorehabilitation. Thu, 14 May 2009 18:28:14 GMT http://bidmc.org/Research/ResearchCenters/BerensonAllenCenterforNoninvasiveBrainStimulation/WhatisTMS.aspx Transcranial Magnetic Stimulation (TMS) is a non-invasive technique that uses the principle of electromagnetic induction to focus induced currents in the brain and modulate the function of the cortex. Tue, 23 Sep 2008 16:52:40 GMT http://bidmc.org/Research/ResearchCenters/BerensonAllenCenterforNoninvasiveBrainStimulation/History.aspx In the late 18th century, Luigi Galvani began laying the foundations for modern electrophysiology and bioelectric theory. While working with a frog sciatic nerve- gastronomies muscle preparation, Galvani showed that the muscle could be made to contract if a zinc electrode attached to the muscle and a copper electrode attached to the nerve were brought in contact with each other. Galvani incorrectly concluded that the contractions were the result of "animal electricity" released from storage in the muscle, only to return via the closed zinc and copper path through the nerve. Tue, 23 Sep 2008 16:52:40 GMT http://bidmc.org/Research/ResearchCenters/BerensonAllenCenterforNoninvasiveBrainStimulation/MiniFellowship.aspx LMBS offers a Mini-Fellowship in Transcranial Magnetic Stimulation three times per year. This Fellowship provides a unique opportunity for hands-on learning of the basic principles, standards of use, and potential applications in neuropsychiatry of TMS. The Mini-Fellowship is conducted in small groups with formal teaching sessions and ample practical exposure. At the end of the Mini-Fellowship the participants will have learned and directly experienced how to determine motor threshold, how to record motor evoked potentials, how to conduct cortical mapping and paired-pulse TMS studies, how to safely apply repetitive TMS, how to design TMS studies, write TMS protocols, and apply for an investigational device exemption from the Food and Drug Administration. Those interested in obtaining more detailed information should select the Contact This Program button at the top of the page. Mon, 17 Nov 2008 21:14:21 GMT http://bidmc.org/Research/ResearchCenters/BerensonAllenCenterforNoninvasiveBrainStimulation/Publications.aspx Publications for TMS at BIDMC Tue, 23 Sep 2008 16:52:40 GMT http://bidmc.org/Research/ResearchCenters/CenterforVascularBiologyResearch.aspx The Center for Vascular Biology Research will promote interdisciplinary communication and collaboration to enhance vascular biology research, from basic to translational. The Center will transcend traditional barriers between specialty areas and will encourage clinicians and scientists to formulate creative approaches to the study of vascular biology. By training the leaders of tomorrow in vascular biology, the Center will work towards a goal of improved care. Mon, 16 Feb 2009 18:11:38 GMT http://bidmc.org/Research/ResearchCenters/TransplantResearchCenter.aspx BIDMC’s Transplant Research Center and its principal investigators in the departments of surgery and medicine have national and international reputations for excellence and innovation. The center attracts students, fellows and post-doctoral individuals from around the world. In total, there are over 70 investigators in the Transplant Research Center, which is funded by more than $11 million in grants. Investigators engaged in bench research study the chemical and molecular make-up of cells and tissues for clues about organ rejection and tolerance. Their discoveries become the foundation for clinical research here and around the world. Mon, 16 Feb 2009 19:57:59 GMT http://bidmc.org/Research/ClinicalInvestigatorTrainingProgram.aspx Clinical Investigator Training Program at BIDMC. Thu, 17 Sep 2009 15:36:52 GMT http://bidmc.org/Research/ClinicalInvestigatorTrainingProgram/Requirements.aspx The two-year fellowship program is open to physicians who have completed the clinical requirements for Board eligibility in their chosen specialty/subspecialty. A formal application must be submitted which should include biographical data, references, career goals, and a specific proposal for a clinical project, including the identification of the candidate’s mentor. The fellowship is mentor-based and project-oriented. Fellows are required to devote at least 80% of their time to the program; the remaining time is allotted to committments in their sponsoring departments. Mon, 14 Sep 2009 17:49:23 GMT http://bidmc.org/Research/ClinicalInvestigatorTrainingProgram/ApplytoProgram.aspx Apply to the Clinical Investigator Training Program at BIDMC. Mon, 14 Sep 2009 20:34:21 GMT http://bidmc.org/Research/ClinicalInvestigatorTrainingProgram/ElectiveMastersDegree.aspx The fellows have the option to pursue a Master of Medical Sciences Degree from Harvard Medical School in conjunction with The Clinical Investigator Training Program. Thu, 12 Feb 2009 19:32:06 GMT http://bidmc.org/Research/ClinicalInvestigatorTrainingProgram/Leadership.aspx Leadership for the Clinical Investigator Training Program Mon, 14 Sep 2009 18:19:17 GMT http://bidmc.org/Research/ClinicalInvestigatorTrainingProgram/Fellows.aspx Clinical Investigator Training Program Fellows Wed, 23 Sep 2009 20:35:54 GMT http://bidmc.org/Research/Laboratories.aspx A listing of the various research laboratories at Beth Israel Deaconess Medical Center. Tue, 28 Apr 2009 15:06:53 GMT http://bidmc.org/Research/TechnologyVenturesOffice.aspx TVO is comprised of a group of technically trained and business-oriented professionals. We work with biomedical companies, venture capitalists, and entrepreneurs to find the best way to commercialize new technologies, and to promote corporate collaborations that can increase our level of industrial support for research. Wed, 11 Mar 2009 20:08:41 GMT http://bidmc.org/Research/ResearchHighlights.aspx Each year, BIDMC research faculty are published in prestigious scientific and medical journals, awarded prominent and highly competitive research grants, and recognized for far-ranging scientific achievement. The research highlights represent selected milestones of our research enterprise over the years. Mon, 09 Nov 2009 14:46:14 GMT http://bidmc.org/Research/ResearchHighlights/20092010.aspx BIDMC Research Highlights for 2009. Mon, 09 Nov 2009 14:46:14 GMT http://bidmc.org/Research/ResearchHighlights/20062007.aspx BIDMC Research Highlights for 2006-2007. Sat, 07 Nov 2009 00:30:14 GMT http://bidmc.org/Research/ResearchHighlights/DONOTDELETE/MonthlyFeatures.aspx BIDMC Research Spotlights Mon, 09 Nov 2009 14:36:40 GMT http://bidmc.org/Research/FeatureStories.aspx The research highlights represent selected milestones of our research enterprise in 2009-2010. Mon, 09 Nov 2009 15:03:53 GMT http://bidmc.org/Research/FeatureStories/CancerDreamTeam.aspx Lewis Cantley, PhD, named as leader of cancer "Dream Team" Sun, 08 Nov 2009 16:18:39 GMT http://bidmc.org/Research/FeatureStories/FLARE.aspx FLARE™(Fluorescence-Assisted Resection and Exploration) is a novel imaging system that uses near-infrared (NIR) light to help surgeons better see cancers – while they are performing surgeries. Developed by John Frangioni, MD, PhD, cofounder of BIDMC’s Center for Molecular Imaging, FLARE has, for the first time, been successfully utilized during surgery to efficiently identify sentinel lymph nodes in breast cancer patients. The pilot study currently appears on-line in the Annals of Surgical Oncology. Sun, 08 Nov 2009 16:18:40 GMT http://bidmc.org/Research/FeatureStories/FindingtheMissingLinc.aspx Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang HY. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.Cell. 2007 Jun 29;129(7):1311-23. Sun, 08 Nov 2009 16:18:39 GMT http://bidmc.org/Research/FeatureStories/LeptinandNightShiftWorkers.aspx In an article in the March 2 Advance On-line issue of the Proceedings of the National Academy of Sciences (PNAS), Mantzoros, together with colleagues from the Sleep Disorders Research Program at Brigham and Women’s Hospital, describe new findings that help explain why night-shift workers are at increased risk of metabolic and cardiac disease, including obesity, diabetes and hypertension. And, among their key discoveries, is the important role that leptin plays. Sun, 08 Nov 2009 16:18:40 GMT http://bidmc.org/Research/FeatureStories/ANewWayofAssessmingSleepDisorders.aspx For individuals with sleep apnea, getting a good night’s rest can be but an elusive dream. A widespread sleep disorder, sleep apnea causes patients to stop breathing for short periods of time throughout the night leaving them groggy and unrested, no matter how early their bedtimes. The condition is as common as adult diabetes, affecting upwards of 12 million individuals in the U.S., and doctors suspect that many more cases of sleep apnea may be undiagnosed -- and untreated. Now, a new technique developed by a scientific team at Beth Israel Deaconess Medical Center (BIDMC) uses information gleaned from an electrocardiogram (ECG) to diagnose sleep apnea and distinguish “healthy sleep” from “unhealthy sleep.” Known as a cardiopulmonary coupling (CPC) system, the technique has been incorporated into devices and software which is manufactured by Embla Systems, Inc. a Colorado-based sleep diagnostic software and equipment company. The CPC technology is currently being distributed throughout Europe and the U.S. Sun, 08 Nov 2009 16:18:39 GMT http://bidmc.org/Research/FeatureStories/NewResearchShedsLightonToneDeafness.aspx In the August 19 issue of The Journal of Neuroscience, Psyche Loui, PhD, a researcher in the Music and Neuroimaging Laboratory at BIDMC, together with lab director Gottfried Schlaug, MD, PhD, and neuroradiologist David Alsop, MD, describe new research that shows a missing brain circuit among people who are tone deaf, offering the first clear explanation for why some people can’t carry a tune. We asked Loui about her research findings. Fri, 13 Nov 2009 17:36:45 GMT http://bidmc.org/Research/FeatureStories/TrainingtheTranslationalReseacher.aspx Today’s growing emphasis on translational research means that the need for clinical investigators has never been greater. And that’s where BIDMC's Clinical Investigator Training Program (CITP) comes in. Sun, 08 Nov 2009 16:18:40 GMT http://bidmc.org/Research/FeatureStories/ZebrafishProvideCluestoHumanDisease.aspx To all appearances, the zebrafish is your typical aquarium dweller. But over the past 30 years, the tiny translucent creature has become an important research model used by scientists to study a host of conditions, including cancers, neurological diseases and blood disorders. As a result, today you’re as likely to find zebrafish inhabiting laboratories of biomedical research centers as you are to find them in pet stores or home fish tanks. Early this month, Beth Israel Deaconess Medical Center (BIDMC) officially unveiled its Zebrafish Laboratory, an 1,800-square-foot facility housing more than 3,000 tanks filled with 100,000 fish. Jointly created through BIDMC’s Departments of Medicine and Pathology, the laboratory is a veritable sea of translucent vertebrates, which are providing scientists with important clues to a vast array of human diseases and conditions. Sun, 08 Nov 2009 16:18:40 GMT