Landmark Papers by Faculty
A major contribution to the controversy on drug-elting stents.
Mauri L, Hsieh WH, Massaro JM, Ho KK, D'Agostino R, Cutlip DE. Stent thrombosis in randomized clinical trials of drug-eluting stents.
N Engl J Med. 2007; 356:1020-9.
How statins cause muscle damage.
Hanai JI, Cao P, Tanksale P, Imamura S, Koshimizu E, Zhao J, Kishi S,
Yamashita M, Phillips PS, Sukhatme VP, Lecker SH. The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. J Clin Invest. 2007; 117(12):3940-51.
Cause of myocardial fibrosis in ventricular remodeling.
Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, Neilson EG, Sayegh MH, Izumo S, Kalluri R. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med. 2007; 13:952-61.
The breast cancer screening controversy analyzed by our Program Director.
Armstrong K, Moye E, Williams S, Berlin JA, Reynolds EE. Screening mammography in women 40 to 49 years of age: a systematic review for the American College of Physicians. Ann Intern Med. 2007;146:516-26.
How the brain senses hypoglycemia.
Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, Zhang CY, Xu C, Vianna CR, Balthasar N, Lee CE, Elmquist JK, Cowley MA, Lowell BB.
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature. 2007; 449:228-32.
The first protein sequences from a dinosaur – Jurassic Park?
Asara JM, Schweitzer MH, Freimark LM, Phillips M, Cantley LC. Protein sequences from mastodon and Tyrannosaurus rex revealed by mass
spectrometry. Science. 2007; 316:280-5.
Bill Maisel heads a new center to monitor device safety nationwide.
Maisel WH. Semper fidelis--consumer protection for patients with implanted medical devices. N Engl J Med. 2008; 358:985-7.
Medicare data to look at optimal treatment of AAA.
Schermerhorn ML, O'Malley AJ, Jhaveri A, Cotterill P, Pomposelli F, Landon BE. Endovascular vs. open repair of abdominal aortic aneurysms in the Medicare population. N Engl J Med. 2008; 358:464-74.
Proteomics to uncover biomarkers for cirrhosis and hepatocellular carcinoma.
Zinkin NT, Grall F, Bhaskar K, Otu HH, Spentzos D, Kalmowitz B, Wells M,Guerrero M, Asara JM, Libermann TA, Afdhal NH. Serum Proteomics and Biomarkers in Hepatocellular Carcinoma and Chronic Liver Disease. Clin Cancer Res. 2008; 14:470-477.
The famous Warburg effect explained: How cancer cells burn glucose by glycolysis to grow wildly.
Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature. 2008; 452:181-6.
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 2008; 452:230-3.
An important clinical trial on catheter ablation led by Mark Josephson, our Chief of Cardiology.
Reddy VY, Reynolds MR, Neuzil P, Richardson AW, Taborsky M, Jongnarangsin K, Kralovec S, Sediva L, Ruskin JN, Josephson ME.
Prophylactic catheter ablation for the prevention of defibrillator therapy. N Engl J Med. 2007; 357:2657-65.
Arsenic and old lace: targeting stem cells to eradicate leukemia.
Ito K, Bernardi R, Morotti A, Matsuoka S, Saglio G, Ikeda Y, Rosenblatt J, Avigan DE, Teruya-Feldstein J, Pandolfi PP. PML targeting eradicates quiescent leukaemia-initiating cells. Nature 2008; 453:1072-8.
How much does your coverage affect your decision-making about healthcare?
Wharam JF, Galbraith AA, Kleinman KP, Soumerai SB, Ross-Degnan D, Landon BE. Cancer screening before and after switching to a high-deductible health plan. Ann Intern Med. 2008; 148:647-55.
At the heart of pre-eclampsia is the placenta; this is one of a series of landmark papers by our faculty on the subject.
Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S,
Augustin HG, Gattone VH, Folkman J, Strauss JF, Kalluri R.
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature 2008; 453:1117-21.
A novel way to sense and respond to hypoxia in limb ischemia.
Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, Baek KH, Rosenzweig A, Spiegelman BM. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature 2008; 451:1008-12.
When the tumor suppressor PTEN is excluded from the nucleus, cancers progress. This paper explains nuclear exclusion.
Song MS, Salmena L, Carracedo A, Egia A, Lo-Coco F, Teruya-Feldstein J, Pandolfi PP. The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. Nature. 2008 Aug 20. [Epub ahead of print]
