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Acute Care Surgery and Critical Care

Trauma, hemorrhagic shock, and burns initiate cellular immune responses with detrimental effects on the clinical outcome of trauma patients.

In the early phase after trauma, overwhelming inflammation causes neutrophil activation and subsequent organ damage that can result in adult respiratory distress syndrome (ARDS) and multiple organ failure (MOF).

In the later phase after trauma, suppressive mediators found in the circulation of patients decrease the ability of lymphocytes to protect the trauma victim from invading microorganisms. This can lead to severe infections and sepsis that are major reasons for trauma deaths.

Trauma surgery research focuses on the cellular and molecular mechanisms that are involved in the cellular immune response to trauma as well as novel therapeutic approaches to modulate this response.

Click on the links below to learn more about our research:

Carl Hauser, MD
Wolfgang Junger, PhD
Teresa Sanchez, PhD
Michael Yaffe, MD, PhD